Rotavirus infections are the main cause of gastroenteritis in infants and children and it is expected that by the age of five years, nearly every child will have experienced at least one episode of rotavirus gastroenteritis. While severe cases …

This briefing paper provides an overview of the tools and interventions involved with an integrated approach to diarrheal disease control, including vaccines, oral rehydration therapy, breastfeeding, and zinc treatment. The document also advocates …

This commentary, published in Nature Medicine, reviews current trends that may affect whether the most promising of the 350 vaccine candidates under development will eventually be used in programs for the poor in developing countries. It also …

As a supplement to GAVI’s detailed guidelines, the document aims to support decision-making by GAVI-eligible countries in the WHO European region and provides information on the burden of rotavirus disease; efficacy, safety, and …

Introducing rotavirus vaccines, in conjuction with establishing improved hygiene and water purification, represents of the best hope for reducing mortality among children under five years of age in areas where diarrheal disease is a serious burden. …

This article, published in Pediatrics, describes investigators' assessment of intussusception events reported to the Vaccine Adverse Event Reporting System from 2006 through 2012, following the respective introductions of RotaTeq® (Merck & …

This article, published in Vaccine, reports that surveillance conducted following routine rotavirus vaccination in Australia did not find an overall increase in intussusception with use of RotaTeq® (Merck & Co., Inc.) and Rotarix® …

This article, published in The New England Journal of Medicine, assesses the association of the monovalent rotavirus vaccine (RV1) with intussusception after routine immunization of infants in Mexico and Brazil. The authors found that RV1 was …

This comprehensive report includes expert articles on a variety of vaccine-related topics and updates on vaccine research for specific infectious diseases, such as influenza, malaria, respiratory syncytial virus, and rotavirus.

This 25-minute BBC World documentary, produced by Rockhopper TV, explores how a new vaccine is promising to change the global rotavirus situation by examining a new approach to drug development and licensing pioneered by GlaxoSmithKline and the …

This landscape analysis identifies trends in the availability of vaccines and novel vaccine delivery technologies that are and will be of relevance to low- and middle-income countries from the present through 2025.

Published in The Archives of Medical Research, this article reviews the high costs of diseases of poverty, increasing diarrhea morbidity (despite decreasing mortality), and new emerging evidence for long-term consequences of early childhood …

This manual, published by the World Health Organization, explains the most common procedures for rotavirus strain surveillance. It describes the methods and techniques used for the detection and characterization of rotaviruses.

This report, published in the Weekly Epidemiological Record, provides a summary of the World Health Organization's Diarrhoeal and Enteric Vaccines Advisory Committee's (DEVAC) annual meeting in October 2008. DEVAC, a 12-member group of experts, …

This article, from the Weekly Epidemiological Record, reports on the outcome of a meeting of the World Health Organization's independent, authoritative vaccine safety committee where they reviewed postmarketing surveillance that indicated the …

This web page provides information about work being done to improve immunization monitoring and surveillance data in order to provide decision-makers with critical information both before vaccine introduction, as related to the existing disease …

This web page on the Vaccine Resource Library provides links to PATH's work on rotavirus, as well as general information about the disease and the current vaccine landscape.

This article, published in BMC Pediatrics, reports on research that evaluated perceptions among physicians and mothers after the 2011 finding of DNA fragments of Porcine circovirus in rotavirus vaccines. Physicians expressed that the finding was of …

This informative article, published in the journal Scientific American, outlines the landscape of new vaccines and their potential impact. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

This article, published in The Scientist, discusses the development of Rotarix® and RotaTeq®, in addition to other rotavirus vaccines under development in India. ABSTRACT ONLY. (Learn how users in developing countries can …

This editorial summarizes the characteristics of studies on rotavirus epidemiology and disease burden in Europe, published in a special supplement to the Journal of Infectious Diseases.

This presentation from an informal consultation on proposed World Health Organization guidelines to assure quality, safety, and efficacy of live, attenuated rotavirus vaccines reported on studies of the safety and efficacy of the RotaTeq® …

This toolkit was developed to help increase awareness of the burden of rotavirus disease and the power of rotavirus vaccines to prevent childhood deaths and hospitalizations. It contains key messages, fact sheets, country introduction maps, and …

This article, published in Human Vaccines, provides a review of published data on previous candidate rotavirus vaccines and vaccines in current use, with emphasis on their performance in developed versus developing countries. In developed countries, …

This book provides physicians, nurses, nurse practitioners, physician assistants, pharmacists, and others with the most comprehensive information on vaccine-preventable diseases. In addition to chapters on more general vaccine-related topics, it …