Technologies related to the temperature control of vaccines during the distribution process are essential to the cool chain. This report provides a landscape analysis of these technologies and their appropriateness for use with vaccines in …

This white paper provides an analysis of supply-side constraints and demand-side determinants of routine immunization coverage in Nigeria. It emphasizes that tackling the basic barriers to routine immunization in Nigeria—cold chain, transport, …

Project Optimize and the Tunisian Ministry of Public Health are collaborating to explore new logistics and supply chain solutions that can optimize the vaccine supply chain. This report describes a study that project Optimize commissioned to assess …

This report summarizes the design and key findings of temperature monitoring studies that gathered ambient temperature data during different HPV vaccine delivery strategies and in multiple geographic settings and seasons.

This report discusses a five-year human papillomavirus (HPV) vaccine demonstration project in Uganda that aims to demonstrate how existing health systems can be adapted to successfully provide HPV vaccine to young adolescent girls. HPV vaccine …

In consideration of the volatile global economy, the growing costs of airfreight, and the risk associated with diminished air cargo capacity, project Optimize evaluated ocean freight as a potentially secure and economic alternative method to …

This article, published in Expert Review of Vaccines, reviews approaches being used to develop thermostable vaccine formulations that are resistant to damage caused by freezing or excessive heat and could reduce dependence on the cold …

The Op.ti.mize e-newsletter is a quarterly publication that highlights advances and innovations in health care logistics, technologies, and policy. Developed by Project Optimize, a collaboration between the World Health Organization and PATH, this …

This report presents the results of demonstration projects and other activities undertaken in Albania as part of a partnership between project Optimize (a collaboration between the World Health Organization and PATH) and the Albanian Institute of …

Optimize, a collaboration between the World Health Organization and PATH, has been given a unique mandate to think far into the future: to put technological and scientific advances to work, helping define the ideal characteristics and …

Project Optimize and the Vietnamese National Institute of Hygiene and Epidemiology collaborated on a series of activities designed to assess the opportunities and needs for strengthening the immunization system in Vietnam. This document reports the …

This report presents the results of demonstration projects and other activities undertaken in Senegal from 2009 to 2012 as part of a partnership between project Optimize and the Senegalese Ministry of Health. The activities aimed to demonstrate …

This document provides a brief overview of the Optimize project's strategy for developing delivery systems that are as advanced and innovative as the vaccines they support. Optimize, a collaboration between the World Health Organization and …

This report presents the results of demonstration projects and other activities undertaken in Vietnam as part of a partnership between project Optimize and Vietnam’s Ministry of Health. The activities aimed to demonstrate innovations in …

Between 2010 and 2012, project Optimize collaborated with Vietnam’s National Institute of Hygiene and Epidemiology to demonstrate innovations in the supply chain that can help to meet the demands expected as Vietnam’s immunization …

This document summarizes the results of a study of out-of-the-cold-chain approaches for improving on-time delivery of birth doses of the hepatitis B vaccine in four districts of Vietnam.

More and more countries are engaging the private sector in vaccine supply chain and logistic functions. As a part of this review, a case study was conducted in the Western Cape of South Africa whereby the Biovac Institute (a third-party, …

This evidence brief provides supply chain managers in low- and middle-income countries with an overview of the potential benefits of outsourcing components of their vaccine logistics systems to the private sector. It also provides practical …

Correct storage, handling, and administration of vaccines are vital components of a successful immunization program. However, with the large number of different healthcare professionals now involved in delivering vaccine programs on a daily …

This aide-memoire details best practices in how to prevent freeze damage to vaccines.

Vaccine freezing in the cold chain is increasingly recognized as a serious threat to immunization programs. This zipped set of materials includes background information on the freezing problem (two literature reviews and a PowerPoint presentation); …

Using new technologies and scientific advances, project Optimize intends to help transform the vaccine supply chain, enabling it to meet the demands of an increasingly large and costly portfolio of vaccines. This project Optimize flickr photostream …

This fact sheet describes how PATH developed a low-cost and straightforward technology for protecting aluminum-adjuvanted liquid vaccines from the irreversible damage that results from freezing. Many current vaccines of importance to global …

This protocol is designed to document the level of freezing in the cold chain and identify specific problem areas where corrective actions are warranted. It can be tailored to an individual program’s resources: a simple, low-cost study can be …

This job aid illustrates how to read time-temperature indicators with the Uniject® device, which is an autodisable, prefilled, single-use syringe that can be used with vaccines.