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Disease: Malaria

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10 Tips for Successful Malaria Vaccine Advocacy

Slow decision-making by policymakers can contribute to a substantial lag between the availability of lifesaving interventions, such as vaccines, and developing countries’ access to them. This booklet presents a set of advocacy tips, success …

Author: PATH

Publication date: 2012

Accelerating US Progress in Combating Malaria Worldwide: Recommendations for Maximizing Investments Toward a World Free From Malaria

This policy paper provides PATH's recommendations for the US Administration and Congress to accelerate progress toward a malaria-free world. By fully funding malaria programs, intensifying support for research and development, and leveraging US …

Author: PATH

Publication date: 2017

Action and Investment to Defeat Malaria 2016–2030

This report, intended to be an advocacy tool, positions malaria as a wider issue for international development and builds the case for additional investment in malaria. It also identifies actions that governments, civil society, the health sector, …

Author: World Health Organization; Roll Back Malaria Partnership

Publication date: 2015

Advancing Vaccines and Immunization Issues, Insights, and Innovations

This supplement of Vaccine contains 16 articles that cover a broad spectrum of important issues in vaccine science, including vaccine safety, efficacy, and implementation. The overarching theme revolves around identifying barriers to vaccination and …

Author: Artenstein AW, Halsey NA, Nowak GJ, eds.

Publication date: 2015

Analysis of World Health Organization Policy Development Processes for a New Intervention: Malaria Vaccines

This document aims to elucidate the World Health Organization (WHO) process for developing policy guidelines for a malaria vaccine. The analysis considered past WHO recommendations on new interventions and assessed potential implications …

Author: PATH

Publication date: 2008

Apical Membrane Antigen 1: A Malaria Vaccine Candidate in Review

This article, published in Trends in Parasitology, presents the current understanding of apical membrane antigen 1 (AMA1), particularly in relation to the potential of AMA1 as a malaria vaccine and the approaches being taken toward clinical …

Author: Remarque EJ, Faber BW, Kocken CH, Thomas AW

Publication date: 2008

Artemisinin Resistance in Plasmodium falciparum Malaria

This study, published in the New England Journal of Medicine, compares the efficacies of two treatments--oral artesunate and artesunate followed by mefloquine--for uncomplicated falciparum malaria in Pailin, western Cambodia, and Wang Pha, …

Author: Dondorp AM, Nosten F, Yi P, et al.

Publication date: 2009

Assessment of Pfs25 Expressed from Multiple Soluble Expression Platforms for Use as Transmission-Blocking Vaccine Candidates

Transmission-blocking vaccines (TBVs) have become a focus of strategies to control and eventually eliminate malaria as they target the entry of sexual stage into the Anopheles stephensi mosquito thereby preventing transmission, an essential …

Author: Lee S-M, Wu C-K, Plieskatt J, et al.

Publication date: 2016

Beyond Efficacy: The Full Public Health Impact of Vaccines

This conference report, published in Vaccine, describes an active discussion in the public health community on how to assess and incorporate, in addition to safety and measures of protective efficacy, the full public health value of preventive …

Author: Saadatian-Elahi M, Horstick O, Breiman RF, et al.

Publication date: 2016

The Biological Function of Antibodies Induced by the RTS,S/AS01 Malaria Vaccine Candidate is Determined by Their Fine Specificity

This article, published in Malaria Journal, discusses how recent vaccine studies have shown that the magnitude of an antibody response is often insufficient to explain efficacy, suggesting that characteristics regarding the quality of the …

Author: Chaudhury S, Ockenhouse CF, Regules JA, et al.

Publication date: 2016

Breaking the Cycle With Vaccines: The Malaria Life Cycle

This graphic displays the malaria parasite's life cycle and highlights where three different types of vaccines could interrupt various stages of the life cycle.

Author: PATH

Building an Effective Malaria Vaccine Portfolio to Address Global Needs

This article, published in Vaccine, examines the research and development pipeline of malaria vaccines. It reviews the latest information on financing, vaccine commercialization, controlled human malaria infection models, and the regulatory …

Author: Birkett AJ

Publication date: 2015

Can Successful Vaccines Teach Us How to Induce Efficient Protective Immune Responses?

This article, published in Nature Medicine, reviews current successful vaccines and identifies their mechanisms of protection in the hopes of tackling the challenges posed by those infectious targets that have thus far escaped successful …

Author: Lambert PH, Liu M, Siegrist CA

Publication date: 2005

Center for Vaccine Innovation and Access

This website provides information about the work of PATH’s Center for Vaccine Innovation and Access, which brings together expertise across every stage of vaccine research, development, and introduction to make lifesaving vaccines globally …

Author: PATH

A Chemiluminescent-Western Blot Assay for Quantitative Detection of Plasmodium falciparum Circumsporozoite Protein

Highly sensitive and reliable assays based on the quantitation of immunologically relevant component(s) in recombinant or whole parasite-based vaccines would facilitate pre-clinical and clinical phases and the monitoring of malaria vaccine …

Author: Kumar S, Zheng H, Sangweme DT, et al.

Publication date: 2013

Clinical Trials: Steps in Malaria Vaccine Development

This fact sheet provides an overview of the development and testing of malaria vaccine candidates through clinical trials, including an explanation of why trials are important and descriptions of each clinical trial phase.

Author: PATH

Publication date: 2009

Community Perceptions of Malaria and Vaccines in the South Coast and Busia Regions of Kenya

Malaria is a leading cause of morbidity and mortality in children younger than 5 years in Kenya. Within the context of planning for a vaccine to be used alongside existing malaria control methods, this study, published in Malaria …

Author: Ba-Nguz A, Bingham A, Collymore Y, et al.

Publication date: 2011

Community Perceptions of Malaria and Vaccines in Two Districts of Mozambique

Malaria is a leading cause of mortality and morbidity in Mozambique, with nearly three-quarters of the country’s malaria-related deaths occurring in children younger than five years. A malaria vaccine is not yet available, but planning is …

Author: Bingham A, Gaspar F, Lancaster K, Conjera J, Collymore Y, Ba-Nguz A

Publication date: 2012

Costing RTS,S Introduction in Burkina Faso, Ghana, Kenya, Senegal, Tanzania, and Uganda: A Generalizable Approach Drawing on Publicly Available Data

This article, published in Vaccine, proposes a generalizable methodology to estimate the cost of introduction of the RTS,S/AS01 malaria vaccine in African countries (Burkina Faso, Ghana, Kenya, Senegal, Tanzania, and Uganda) using routinely …

Author: Galactionova K, Bertram M, Lauer J, Tediosi F

Publication date: 2015

Country Specific Predictions of the Cost-Effectiveness of Malaria Vaccine RTS,S/AS01 in Endemic Africa

This article, published in Vaccine, examines the cost-effectiveness and impact of malaria vaccine candidate RTS,S/AS01 in Africa. Using a variety of models of Plasmodium falciparum epidemiology, the study found that if RTS,S was implemented in 43 …

Author: Galactionova K, Tediosi F, Camponovo F, Smith TA, Gething PW, Penny MA

Publication date: 2017

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