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Disease: Rotavirus

Total results with these characteristics: 239

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Efficacy of Pentavalent Rotavirus Vaccine Against Severe Rotavirus Gastroenteritis in Infants in Developing Countries in Asia: A Randomised, Double-Blind, Placebo-Controlled Trial

This article, published in The Lancet, assesses the clinical efficacy of the pentavalent, live oral rotavirus vaccine for the prevention of severe rotavirus gastroenteritis in infants in Bangladesh and Vietnam. Study results demonstrated vaccine …

Author: Zaman K, Dang DA, Victor JC, et al.

Published: 2010

Efficacy of Pentavalent Rotavirus Vaccine Against Severe Rotavirus Gastroenteritis in Infants in Developing Countries in Sub-Saharan Africa: A Randomised, Double-Blind, Placebo-Controlled Trial

This article, published in The Lancet, shares results of an efficacy study of the pentavalent, live oral rotavirus vaccine in Ghana, Kenya, and Mali. Results showed 39.3 percent efficacy against  severe rotavirus gastroenteritis. The authors …

Author: Armah GE, Sow SO, Breiman RF, et al.

Published: 2010

Efficacy of the Human Rotavirus Vaccine RIX4414 in Malnourished Children

This study, published in the Journal of Infectious Diseases, determined that the Rotarix® vaccine produced by GlaxoSmithKline decreased the incidence severe gastroenteritis caused by rotavirus at comparable rates among well-nourished and …

Author: Perez-Schael I, Salinas B, Tomat M, et al.

Published: 2007

Evaluaciónde Costo-Efectividad de la Vacuna Anti-rotavirus en Chile

This article, published in Revista Médica de Chile, outlines an economic model that determined rotavirus vaccination is a cost-effective intervention that can effectively reduce the disease burden and healthcare costs of rotavirus …

Author: Constenla D, O'Ryan M, Navarrete M, Antil L, Rheingans R

Published: 2006

Evaluating Clinical Trial Data and Guiding Future Research for Rotavirus Vaccines

This article, published in the Weekly Epidemiological Record, discusses the outcome of a meeting of global, regional, and country-level rotavirus experts and immunization opinion leaders who gathered to provide guidance on evaluating and …

Author: World Health Organization

Published: 2008

Evaluating the Potential Risks and Benefits of Infant Rotavirus Vaccination in England

This article, published in Vaccine, reports on a risk-benefit analysis of rotavirus vaccination that compared potential vaccine-related risks with estimated vaccine benefits in the 2012 birth cohort in England. The authors estimate that rotavirus …

Author: Clark A, Jit M, Andrews N, Atchison C, Edmunds WJ, Sanderson C

Published: 2014

Evaluation of Anatomic Changes in Young Children with Natural Rotavirus Infection: Is Intussusception Biologically Plausible?

This study, published in the Journal of Infectious Diseases, explores the biological plausibility of intussusception caused by natural rotavirus infection.

Author: Robinson C, Hernanz-Schulman M, Zhu Y, et al.

Published: 2004

Evaluation of Cost-Effectiveness of Live Oral Pentavalent Reassortant Rotavirus Vaccine Introduction in Ghana

This article, published in Vaccine, estimates the cost-effectiveness of introducing the rotavirus vaccine RotaTeq® in Ghana. The authors estimated the average costs of treating children with diarrhea in the Ashanti region of Ghana as inpatients …

Author: Abbott C, Tiede B, Armah G, Mahmoud A

Published: 2012

Evaluation of Vaccines Against Enteric Infections: A Clinical and Public Health Research Agenda for Developing Countries

This article, from the Philosophical Transactions of the Royal Society B, provides a review of the enteric vaccines currently available and their lack of use in developing countries. The author purports that the reasons for this are multiple and …

Author: Clemens J

Published: 2011

Exploring New, Non-replicating Rotavirus Vaccines

This fact sheet summarizes the technical efforts and objectives of PATH's non-replicating rotavirus vaccine (NRRV) development project. It outlines the vaccine candidates under evaluation and primary partners, as well as the rationale for the NRRV …

Author: PATH

Published: 2013

Fatal Neglect: How Health Systems Are Failing to Comprehensively Address Child Mortality

WaterAid's report Fatal Neglect: How Health Systems Are Failing to Comprehensively Address Child Mortality shows how the aid system is not responding to the causes of child mortality in a targeted manner. The international health agenda is failing …

Author: WaterAid America

Published: 2009

Fulfilling the Promise of Rotavirus Vaccines: How Far Have We Come Since Licensure?

This review, published in The Lancet Infectious Diseases, summarizes the role of rotavirus vaccination in reducing childhood hospitalizations and deaths due to severe diarrhea. The authors also highlight insights revealed through routine …

Author: Patel MM, Glass R, Desai R, Tate JE, Parashar UD

Published: 2012

Gastroenteritis Hospitalizations in Older Children and Adults in the United States Before and After Implementation of Infant Rotavirus Vaccination

This article, published in the Journal of the American Medical Association, reports on a study that explored the indirect impact of rotavirus vaccines on older age groups. The authors assessed patterns of gastroenteritis hospitalizations among …

Author: Gastañaduy PA, Curns AT, Parashar UD, Lopman BA

Published: 2013

Generic Protocol for Monitoring Impact of Rotavirus Vaccination on Gastroenteritis Disease Burden and Viral Strains

This document outlines a uniform approach to monitoring the impact of rotavirus vaccines in national programs, including guidelines for monitoring disease trends and evaluating vaccine effectiveness and changes in strain patterns among …

Author: World Health Organization

Published: 2008

Generic Protocols for (i) Hospital-Based Surveillance to Estimate the Burden of Rotavirus Gastroenteritis in Children and (ii) a Community-Based Survey on Utilization of Health Care Services for Gastroenteritis in Children

This guide is intended for use in epidemiological surveillance activities aimed at collecting data on rotavirus disease burden.

Author: World Health Organization

Published: 2002

Global Burden of Childhood Pneumonia and Diarrhoea

This article, published in The Lancet, reviews the epidemiology of childhood diarrhea and pneumonia in 2010 to 2011 to inform the planning of integrated control programmes for both illnesses. The estimates show 1.731 billion episodes of diarrhea and …

Author: Walker CL, Rudan I, Liu L, et al.

Published: 2013

Global Impact of Diarrheal Diseases That Are Sampled by Travelers: The Rest of the Hippopotamus

Travelers who experience diarrhea are exposed to the same pathogens and illnesses that pose some of the greatest threats to life and development among malnourished children in developing areas around the world, where inadequate water and poor …

Author: Guerrant RL, Oria R, Bushen OY, et al.

Published: 2005

Global Rotavirus Information and Surveillance Bulletin

The World Health Organization (WHO)-coordinated Global Rotavirus Surveillance Network (GRSN), which was launched in 2008, includes six regional WHO rotavirus surveillance networks worldwide. Its objectives include documenting the presence of …

Author: World Health Organization

Guidelines for Estimating the Economic Burden of Diarrheal Disease with Focus on Assessing the Costs of Rotavirus Diarrhea

WHO developed these guidelines to present a method for determining the costs associated with diarrheal disease in children under 5 years of age.

Author: World Health Organization

Published: 2002

Guidelines to Assure the Quality, Safety, and Efficacy of Live Attenuated Rotavirus Vaccines (oral)

Intended for use by National Regulatory Authorities NRAs and vaccine manufacturers, this document provides guidelines on production, quality control, and safety/efficacy evaluation of live,attenuated, oral rotavirus vaccines.

Author: World Health Organization

Published: 2005

Health Care Costs of Diarrheal Disease and Estimates of the Cost-Effectiveness of Rotavirus Vaccination in Vietnam

This study, published in The Journal of Infectious Diseases, estimated economic burden and the vaccination cost-effectiveness ratio to determine potential reductions in health care costs associated with rotavirus-specific diarrhea.

Author: Fischer T, Anh D, Antil L, et al.

Published: 2005

Health Economics of Rotavirus Immunization in Vietnam: Potentials for Favorable Cost-Effectiveness in Developing Countries

This article, published in Vaccine, reports on a study designed to assess the cost-effectiveness of rotavirus immunization in Vietnam. It specifically focused on the use of RotaTeq® and assessing the affordability of implementing universal …

Author: Tu HA, Rozenbaum MH, Coyte PC, Li SC, Woerdenbag HJ, Postma MJ

Published: 2012

Hospitalizations for Intussusception Before and After the Reintroduction of Rotavirus Vaccine in the United States

This article, published in the Archives of Pediatrics & Adolescent Medicine, reports on a study that examined hospital discharges for intussusception among infants in the United States before and after the introduction of RotaTeq® and …

Author: Zickafoose JS, Benneyworth BD, Riebschleger MP, Espinosa CM, Davis MM

Published: 2012

Human Rotavirus Vaccine Rotarix Provides Protection Against Diverse Circulating Rotavirus Strains in African Infants: A Randomized Controlled Trial

This article, published in BMC Infectious Diseases, discusses a study where Rotarix® vaccine demonstrated efficacy against severe gastroenteritis caused by diverse circulating rotavirus types. These data add to evidence that the vaccine …

Author: Steele AD, Neuzil KM, Cunliffe NA, et al.

Published: 2012

Immune Responses and Protection in Children in Developing Countries Induced by Oral Vaccines

Oral mucosal vaccines have great promise for generating protective immunity against intestinal infections for the benefit of large numbers of people especially young children. However, these vaccines are not equally immunogenic nor protective in …

Author: Qadri F, Bhuiyan TR, Sack DA, Svennerholm A-M

Published: 2013

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