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Topic: Vaccine stabilization

Total results with these characteristics: 44

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Pull Mechanisms for Value-Added Technologies for Vaccines

Project Optimize, a collaboration between PATH and the World Health Organization, commissioned this white paper to examine the issues influencing vaccine producer willingness to advance, adopt, and commercialize value-added technologies for …

Author: PATH, World Health Organization

Published: 2009

Reconstitution Technologies

This fact sheet provides an overview of single-dose, prefilled reconstitution devices (SPRDs), which can make reconstitution of critical vaccines safer and more economical. SPRDs can help eliminate adverse events or wastage that can occur with …

Author: PATH

Published: 2013

Spray Drying and Vaccine Stabilization

Research on spray drying as a processing method to improve vaccine stabilization and to enable novel routes of vaccine delivery has produced promising results; however, the method has yet to be adopted for the manufacture of vaccine products by the …

Author: McAdams D, Chen D, Kristensen D

Published: 2012

Stability of Vaccines – Bridging From Stability Data to Continuous Safety and Efficacy Throughout Shelf Life – An Always Reliable Approach?

This article, published in Biologicals, discusses why stability studies are important tools to reliably ensure that the efficacy and safety of medicinal products remain unchanged from release of drug product until the end of shelf life. The author …

Author: Pfleiderer M

Published: 2009

Stabilization of Vaccines: Lessons Learned

This editorial, published in Human Vaccines, explores the key logistical, regulatory, procurement, and policy issues associated with the development and use of temperature-stabilized vaccines. The authors reflect on nearly 8 years of work to …

Author: Kristensen D, Chen D

Published: 2010

Stabilizing Influenza Vaccines

If a highly virulent pandemic strain were to emerge in today’s interconnected world, influenza has the potential to kill millions of people, especially in developing countries with limited to no resources for pandemic planning, preparedness, and …

Author: PATH

Published: 2013

Summary of Vaccine Stability Data

These documents provide stability data as of November 2012 on commonly used, licensed vaccines and stability data as of May 2012 from available data on novel, investigational vaccine formulations. Data are sorted by vaccine in a table format in both …

Author: PATH, Working in Tandem Ltd.

Published: 2012

Taking Advantage of the True Heat Stability of Vaccines

This fact sheet describes work that Project Optimize is doing to enable immunization programs to take advantage of the true stability of vaccines by labeling them for use at ambient temperatures in a controlled temperature chain for limited periods …

Author: PATH, World Health Organization

Published: 2012

Temperature Sensitivity of Vaccines

This document addresses issues regarding potential exposure of temperature-sensitive vaccines to freezing temperatures and provides updated information on vaccine vial monitors, as well as a discussion of future advances in cold chain technology.

Author: World Health Organization

Published: 2006

Thermostable Formulations of a Hepatitis B Vaccine and a Meningitis A Polysaccharide Conjugate Vaccine Produced by a Spray-Drying Method

This article, published in the journal Vaccine, reports that employing a spray-drying process to produce glassy state formulations of two common subunit vaccines demonstrates that the production of thermostable vaccines is achievable. The process …

Author: Chen D, Kapre S, Goel A, et al.

Published: 2010

US Department of Health and Human Services and PATH: Partnering to Protect and Improve Global Health

PATH and the US Department of Health and Human Services (HHS) work together to improve global health around the world. This fact sheet highlights PATH projects—including work to develop a stable vaccine supply to prevent a public health …

Author: PATH

Published: 2013

Use of Vaccines Outside of the Cold Chain: A Literature Review

This review compiles the literature available on the use of vaccines outside of the cold chain. Most of the studies analyzed in this review focus on hepatitis B, except one that examines meningococcal Group C vaccine. Most showed that there are no …

Author: PATH, World Health Organization

Published: 2008

A Vaccine Cold Chain Freezing Study in PNG Highlights Technology Needs for Hot Climate Countries

Emphasis has long been placed on keeping vaccines cold, with less attention devoted to prevention of vaccine damage from freezing. Published reports and field evidence now demonstrate that freezing of vaccines in the cold chain is commonplace, …

Author: Wirkas T, Toikilik S, Miller N, Morgan C, Clements CJ

Published: 2006

Vaccine Management and Logistics

This section of the World Health Organization website focuses on vaccine management issues including the cold chain, transport, stock management, and reconstitution of vaccines.

Author: World Health Organization

Vaccine Stabilization

This fact sheet describes PATH's work on vaccine stabilization, including the development of a method to protect vaccines containing an aluminum adjuvant from freeze damage, the identification of a technology to improve the heat stability of certain …

Author: PATH

Published: 2012

Vaccine Stabilization: Research, Commercialization, and Potential Impact

This article, published in Vaccine, discusses the challenges of different approaches to developing and producing thermostable vaccines. Topics include the technical feasibility of improving vaccine thermostability and thus vaccine effectiveness …

Author: Kristensen D, Chen D, Cummings R

Published: 2011

Vaccine Technologies at PATH

PATH and its partners have been advancing innovative vaccine technologies for more than 30 years. This report outlines PATH's approach and capabilities. It also describes a number of individual vaccine technologies at various …

Author: PATH

Published: 2010

Vaccines in Fast-Dissolving Tablets: Novel Product Format to Ensure Vaccine Effectiveness, Affordability, and Ease of Use

This fact sheet provides an overview of PATH's work in developing fast-dissolving tablet vaccine formulations that are manufactured using a standard lyophilization process. The small tablets are packaged in unit-dose blisters offering an …

Author: PATH

Published: 2012

Vaccines With Aluminum-Containing Adjuvants: Optimizing Vaccine Efficacy and Thermal Stability

Aluminum-containing adjuvants have been in use in vaccines for decades to enhance immune responses. However, exposure of vaccines containing these adjuvants to temperatures outside of the recommended storage ranges (especially exposure to freezing …

Author: Clapp T, Siebert P, Chen D, Jones Braun L

Published: 2010

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