This document summarizes the results of a study of out-of-the-cold-chain approaches for improving on-time delivery of birth doses of the hepatitis B vaccine in rural areas of China. The study concluded that this is a safe and effective way to …

This document provides a literature review of articles about evidence of vaccine freezing in the cold chain. The document is part of a series that describes the serious risk of freezing vaccines and World Health …

Good cold chain practice is essential to maintain full immunogenicity of vaccines. This article, published in Vaccine, reports on a study that aimed to identify the likelihood and extent of exposure to inappropriate temperatures in the vaccine cold …

This analysis, published in the journal Vaccine, highlights the pervasiveness of accidental freezing across the cold chain and makes recommendations for addressing the problem. ABSTRACT ONLY. (Learn how users in developing countries can gain free …

This excellent, comprehensive training manual addresses and answers important questions about using VVMs in the field.

This widely used reference from WHO has been updated according to new developments in vaccine stability, temperature monitoring, and recently pre-qualified vaccines.

Many health facilities in remote areas operate without grid electricity, have unreliable electricity, or find that using electricity is too costly. In these settings, solar energy is a promising solution for powering the storage and transportation …

A major problem in immunization programs throughout the world has been the challenge of monitoring and managing the temperature of vaccines as they travel through the distribution chain to the destinations where they are used. This report …

This article, published in Human Vaccines, discusses a study to develop a formulation of recombinant hepatitis B vaccine with improved stability at elevated temperatures. A new vaccine formulation has the potential to be used outside the cold chain …

This document outlines the introduction process for hepatitis B vaccine into national immunization services. It offers a summary of WHO policies and practices regarding hepatitis B immunization, and includes information on immunization …

This study, published in the Bulletin of the World Health Organization, aimed to document and characterize freezing temperatures in the Indonesian vaccine cold chain to evaluate the feasibility of changes designed to reduce the occurrence of …

This report summarizes workshops held in July 2010 by Project Optimize (a collaboration between PATH and the World Health Organization) in Washington, DC, and Seattle to engage stakeholders from a wide variety of organizations related to …

Part of the "Training Resource Series," this training manual for vaccinators can be adapted for specific national programs. In addition to key technical content—including sections on using monovalent, quadrivalent, or pentavalent Hib vaccine …

Part of the "Training Resource Series," this unique training module was specially designed to be easy to adapt for specific national programs. In addition to key technical content—including sections on using monovalent, quadrivalent, or …

This fact sheet describes PATH’s work to address the problem of vaccines freezing during transport by incorporating an inner vaccine box made of phase-change material into vaccine carriers.

In this article, published in the Journal of Controlled Release, the authors describe how dry-coated microprojections, a needle-free vaccine delivery device, can deliver vaccine to abundant antigen-presenting cells in the skin and induce efficient …

This fact sheet details a collaboration between Project Optimize and the Senegalese Ministry of Health to implement and validate a "moving warehouse" that will streamline the vaccine supply chain from the regional to the peripheral level. A moving …

In areas such as Southeast Asia with a high incidence of mother-to-child transmission of hepatitis B, the World Health Organization recommends a birth dose of the vaccine for all children. Hepatitis B vaccine is typically kept refrigerated, within …

This document describes the partnership that created the vaccine vial monitor, providing a useful example to policymakers, funders, nongovernmental and multilateral organizations, and product developers of how the public and private sectors can …

This fact sheet provides an overview of PATH's work to develop and deliver innovative health solutions for those who need them most. These solutions range from developing and introducing affordable, appropriate technologies to creating conditions …

WHO recommends that Hib vaccine now be included in routine infant immunization programmes for all children, as appropriate to national capacities and priorities. This manual provides managers with the information they need to implement a …

Introducing rotavirus vaccines, in conjuction with establishing improved hygiene and water purification, represents of the best hope for reducing mortality among children under five years of age in areas where diarrheal disease is a serious burden. …

This brochure describes how advances in vaccine supply chain systems can accelerate the delivery of lifesaving immunizations to people who need them. The document offers recommendations for global policymakers to support countries in building more …

This ten-session lesson plan maps a one-day vaccine introduction training program using existing PATH materials on the SA 14-14-2 Japanese encephalitis (JE) vaccine. Topics include facts about JE, administering the SA 14-14-2 JE vaccine, possible …

The Effective Vaccine Stores Management (EVSM) assessment tool was created to help countries and agencies evaluate critical components of the country’s primary vaccine store. To date, 57 countries have completed the EVSM assessment. This …