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Disease: Malaria

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10 Tips for Successful Malaria Vaccine Advocacy

Slow decision-making by policymakers can contribute to a substantial lag between the availability of lifesaving interventions, such as vaccines, and developing countries’ access to them. This booklet presents a set of advocacy tips, success …

Author: PATH

Publication date: 2012

Advancing Vaccines and Immunization Issues, Insights, and Innovations

This supplement of Vaccine contains 16 articles that cover a broad spectrum of important issues in vaccine science, including vaccine safety, efficacy, and implementation. The overarching theme revolves around identifying barriers to vaccination and …

Author: Artenstein AW, Halsey NA, Nowak GJ, eds.

Publication date: 2015

Analysis of World Health Organization Policy Development Processes for a New Intervention: Malaria Vaccines

This document aims to elucidate the World Health Organization (WHO) process for developing policy guidelines for a malaria vaccine. The analysis considered past WHO recommendations on new interventions and assessed potential implications …

Author: PATH

Publication date: 2008

Apical Membrane Antigen 1: A Malaria Vaccine Candidate in Review

This article, published in Trends in Parasitology, presents the current understanding of apical membrane antigen 1 (AMA1), particularly in relation to the potential of AMA1 as a malaria vaccine and the approaches being taken toward clinical …

Author: Remarque EJ, Faber BW, Kocken CH, Thomas AW

Publication date: 2008

Artemisinin Resistance in Plasmodium falciparum Malaria

This study, published in the New England Journal of Medicine, compares the efficacies of two treatments--oral artesunate and artesunate followed by mefloquine--for uncomplicated falciparum malaria in Pailin, western Cambodia, and Wang Pha, …

Author: Dondorp AM, Nosten F, Yi P, et al.

Publication date: 2009

Beyond Efficacy: The Full Public Health Impact of Vaccines

This conference report, published in Vaccine, describes an active discussion in the public health community on how to assess and incorporate, in addition to safety and measures of protective efficacy, the full public health value of preventive …

Author: Saadatian-Elahi M, Horstick O, Breiman RF, et al.

Publication date: 2016

Breaking the Cycle With Vaccines: The Malaria Life Cycle

This graphic displays the malaria parasite's life cycle and highlights where three different types of vaccines could interrupt various stages of the life cycle.

Author: PATH

Can Successful Vaccines Teach Us How to Induce Efficient Protective Immune Responses?

This article, published in Nature Medicine, reviews current successful vaccines and identifies their mechanisms of protection in the hopes of tackling the challenges posed by those infectious targets that have thus far escaped successful …

Author: Lambert PH, Liu M, Siegrist CA

Publication date: 2005

A Chemiluminescent-Western Blot Assay for Quantitative Detection of Plasmodium falciparum Circumsporozoite Protein

Highly sensitive and reliable assays based on the quantitation of immunologically relevant component(s) in recombinant or whole parasite-based vaccines would facilitate pre-clinical and clinical phases and the monitoring of malaria vaccine …

Author: Kumar S, Zheng H, Sangweme DT, et al.

Publication date: 2013

Clinical Trials: Steps in Malaria Vaccine Development

This fact sheet provides an overview of the development and testing of malaria vaccine candidates through clinical trials, including an explanation of why trials are important and descriptions of each clinical trial phase.

Author: PATH

Publication date: 2009

Community Perceptions of Malaria and Vaccines in the South Coast and Busia Regions of Kenya

Malaria is a leading cause of morbidity and mortality in children younger than 5 years in Kenya. Within the context of planning for a vaccine to be used alongside existing malaria control methods, this study, published in Malaria …

Author: Ba-Nguz A, Bingham A, Collymore Y, et al.

Publication date: 2011

Community Perceptions of Malaria and Vaccines in Two Districts of Mozambique

Malaria is a leading cause of mortality and morbidity in Mozambique, with nearly three-quarters of the country’s malaria-related deaths occurring in children younger than five years. A malaria vaccine is not yet available, but planning is …

Author: Bingham A, Gaspar F, Lancaster K, Conjera J, Collymore Y, Ba-Nguz A

Publication date: 2012

Costing RTS,S Introduction in Burkina Faso, Ghana, Kenya, Senegal, Tanzania, and Uganda: A Generalizable Approach Drawing on Publicly Available Data

This article, published in Vaccine, proposes a generalizable methodology to estimate the cost of introduction of the RTS,S/AS01 malaria vaccine in African countries (Burkina Faso, Ghana, Kenya, Senegal, Tanzania, and Uganda) using routinely …

Author: Galactionova K, Bertram M, Lauer J, Tediosi F

Publication date: 2015

Development of a Transmission-Blocking Malaria Vaccine: Progress, Challenges, and the Path Forward

This article, published in Vaccine, describes the progress made since 2010 in critical areas of developing transmission-blocking malaria vaccines. It also highlights key challenges that remain and outlines important next steps to maximize the …

Author: Nunes JK, Woods C, Carter T, et al.

Publication date: 2014

Disability-Adjusted Life Years (DALYs) for 291 Diseases and Injuries in 21 Regions, 1990–2010: A Systematic Analysis for the Global Burden of Disease Study 2010

This article, published in The Lancet, shares results from the Global Burden of Disease Study, calculating disease burden using disability-adjusted life years (DALYs) both worldwide and for 21 regions for 1990, 2005, and 2010 with methods to enable …

Author: Murray CJL, Vos T, Lozano R, et al.

Publication date: 2012

Disease Outbreak News

This web page provides frequently updated information about current disease outbreaks, as well as disease-specific archives of past alerts and links to related resources.

Author: World Health Organization

Efficacy and Safety of RTS,S/AS01 Malaria Vaccine with or without a Booster Dose in Infants and Children in Africa: Final Results of a Phase 3, Individually Randomized, Controlled Trial

This article, published in The Lancet, reports the results of a study on the efficacy and safety of the RTS,S/AS01 candidate malaria vaccine. The authors conclude that RTS,S/AS01 prevented a substantial number of cases of clinical malaria over a …

Author: RTS,S Clinical Trials Partnership

Publication date: 2015

Efficacy and Safety of the RTS,S/AS01 Malaria Vaccine During 18 Months After Vaccination: A Phase 3 Randomized, Controlled Trial in Children and Young Infants at 11 African Sites

This article, published in PLoS Medicine, reports on follow-up data from a Phase 3 trial conducted to test the effectiveness of the malaria vaccine candidate RTS,S/AS01 in children and young infants. RTS,S/AS01 prevented many cases of clinical and …

Author: RTS,S Clinical Trials Partnership

Publication date: 2014

Efficacy of RTS,S/AS01E Vaccine Against Malaria in Children 5 to 17 Months of Age

This study, published in the New England Journal of Medicine, evaluated the efficacy of the RTS,S malaria vaccine given with a more immunogenic adjuvant system (AS01E) than one used in a previous study (AS02A). The study was conducted in …

Author: Bejon P, Lusingu J, Olotu A, et al.

Publication date: 2008

Factors Likely to Affect Community Acceptance of a Malaria Vaccine in Two Districts of Ghana: A Qualitative Study

This article, published in PLoS ONE, reports on a study that explored community-level factors that could affect future vaccine acceptance in Ghana once a malaria vaccine is recommended for introduction and use. It also provides recommendations for a …

Author: Meñaca A, Tagbor H, Adjei R, et al.

Publication date: 2014

Fighting Malaria Today and Tomorrow

This fact sheet describes PATH's work in malaria control and prevention, including its work under the Malaria Control and Evaluation Partnership in Africa and the PATH Malaria Vaccine Initiative.

Author: PATH

Publication date: 2015

First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children

A malaria vaccine, deployed in combination with current malaria-control tools, could play an important role in future control and eventual elimination of malaria in Africa. This article, published in the New England Journal of Medicine, reports the …

Author: The RTS,S Clinical Trials Partnership

Publication date: 2011

From Pipeline to Product: Malaria R&D Funding Needs Into the Next Decade

This report serves as a tool to guide policymakers’ investment in new tools to control malaria, contain emerging threats, and move toward the goal of eradicating malaria from the world. It looks at the estimated funding needed for Research & …

Author: PATH

Publication date: 2013

Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine

This article, published in The New England Journal of Medicine, reports on an analysis of samples from an efficacy study of the RTS,S/AS01 malaria vaccine to determine whether the vaccine efficacy was specific to certain parasite genotypes at the …

Author: Neafsey DE, Juraska M, Bedford T, et al.

Publication date: 2015

Global and Regional Mortality From 235 Causes of Death for 20 Age Groups in 1990 and 2010: A Systematic Analysis for the Global Burden of Disease Study 2010

This article, published in The Lancet, reports on the results of the Global Burden of Diseases, Injuries, and Risk Factors Study 2010, which aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes. The …

Author: Lozano R, Naghavi M, Foreman K, et al.

Publication date: 2012

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