This website provides comprehensive resources on diarrheal disease treatment interventions, including low-osmolarity oral rehydration solution, zinc treatment, and rotavirus vaccines. Traditional interventions such as improved sanitation and …

This guide is a compilation of publicly available information about the manufacturing process of rotavirus vaccines, and aims to provide a resource for manufacturers interested in developing and registering an attenuated, oral rotavirus vaccine. …

This article, published in The Lancet, discusses diarrheal disease in children in the developed and developing worlds, prevention and treatment options, and what we can learn from looking at diarrheal disease in developed and …

Diarrheal Disease: Solutions to Defeat a Global Killer presents scientific evidence to support strategies to scale up use of interventions, including safe water, improved sanitation and hygiene, breastfeeding and optimal complementary feeding, …

This joint report from the World Health Organization and the United Nations Children's Fund (UNICEF) focuses attention on the prevention and management of diarrheal diseases. It examines the latest available information on the burden of childhood …

This article, published in Clinical Infectious Diseases, is about an active, population-based surveillance for rotavirus gastroenteritis hospitalizations in three United States counties to assess the impact of rotavirus vaccines. The study …

This series of fact sheets describes symptoms of infection as well as the benefits and risk of vaccination for 14 diseases, including hepatitis B, Haemophilus influenzae type b, influenza, pneumococcal disease, polio, and rotavirus. There …

Rotavirus genotypes were identified in several European countries using ELISA tests, and investigators determined that G1–G4 and G9 genotypes were responsible for the majority of cases. Citing these results, the authors suggest that rotavirus …

This article, published in Vaccine, reports on an analysis that combines the results of a country-level model of rotavirus vaccination published elsewhere with data from Demographic and Health Surveys on within-country patterns of vaccine coverage …

This study, published in the Journal of Infectious Diseases, tested the neonatal rotavirus candidate vaccine 116E in a double-blind, placebo-controlled dose-escalation trial in India. Two doses of the Vero cell-adapted vaccine were evaluated in …

This article, published in Pediatrics, summarizes a case-control study conducted at four hospitals in Nicaragua to evaluate the duration of protection after rotavirus vaccination among eligible infants. The pentavalent rotavirus vaccine …

This article, published in the Pan American Journal of Public Health, examines a national rotavirus vaccination program in Mexico and evaluates its costs and benefits. The article concludes that the program would be highly cost-effective and …

This article, published in The New England Journal of Medicine, discusses a study on the efficacy of rotavirus vaccine in Africa. Results showed 30.2 percent efficacy against all-cause severe gastroenteritis. The study concluded that rotavirus …

This article, published in The New England Journal of Medicine, discusses a study on the effectiveness of rotavirus vaccine in Mexico. The study examined the impact of vaccination on diarrheal deaths in Mexican children between 2008 and 2009 …

This article, published in Pediatrics, concludes that after the 2007 introduction of rotavirus vaccine in Mexico, marked and sustained declines in diarrhea deaths were seen among children in all regions of the country, including in the least …

This article, published in The Lancet, presents data that show high efficacy for GSK's Rotarix® administered with routine vaccines. Over two seasons, Rotarix® demonstrated 90 percent efficacy against severe rotavirus among European …

This article, published in The Lancet, assesses the clinical efficacy of the pentavalent, live oral rotavirus vaccine for the prevention of severe rotavirus gastroenteritis in infants in Bangladesh and Vietnam. Study results demonstrated vaccine …

This article, published in The Lancet, shares results of an efficacy study of the pentavalent, live oral rotavirus vaccine in Ghana, Kenya, and Mali. Results showed 39.3 percent efficacy against  severe rotavirus gastroenteritis. The authors …

This study, published in the Journal of Infectious Diseases, determined that the Rotarix® vaccine produced by GlaxoSmithKline decreased the incidence severe gastroenteritis caused by rotavirus at comparable rates among well-nourished and …

In this article, published in the Journal of Clinical Microbiology, researchers identified a broad diversity of rotavirus strains among children in India, including several unusual strains and two novel strains. The study highlights the great …

This study, published in the Journal of Infectious Diseases, of children presenting with mild to severe diarrhea and dehydration at a hospital in Peru describes rotavirus serotypes and risk factors for infection, and offers support for the …

This review of 30 years worth of published data provided insight into the burden of disease and the emergence of new genotypes in Kenya, indicating a need for continued surveillance. ABSTRACT ONLY. (Learn how users in developing countries can …

This literature review, published in the Pan American Journal of Public Health, was performed to assess the disease burden and epidemiology of rotavirus diarrhea in Latin America. ABSTRACT ONLY. (Learn how users in developing countries can …

This study, published in the Bulletin of the World Health Organization, reviews the epidemiology and disease burden of rotavirus diarrhea among children at hospitals and clinics in African countries, covering the period 1975–1992.

Published in The Bulletin of the World Health Organization, this study provides estimates of diarrhea mortality at country, regional, and global levels and discusses interventions to reduce childhood mortality caused by diarrheal disease.