Disease: Shigellosis and enterotoxigenic Escherichia coli (ETEC)
Total results with these characteristics: 72
- Escherichia coli Infections
This web page provides general information on Escherichia coli bacteria and symptoms of disease. It also includes links to other World Health Organization web pages related to E. coli.
Author: World Health Organization
- Estimating Child Mortality Due to Diarrhea in Developing Countries: A Meta-analysis Review
Published in The Bulletin of the World Health Organization, this study provides estimates of diarrhea mortality at country, regional, and global levels and discusses interventions to reduce childhood mortality caused by diarrheal disease.
Author: Boschi-Pinto C, Velebit L, Shibuya K
- Evaluation of Vaccines Against Enteric Infections: A Clinical and Public Health Research Agenda for Developing Countries
This article, from the Philosophical Transactions of the Royal Society B, provides a review of the enteric vaccines currently available and their lack of use in developing countries. The author purports that the reasons for this are multiple and …
Author: Clemens J
- Fatal Neglect: How Health Systems Are Failing to Comprehensively Address Child Mortality
WaterAid's report Fatal Neglect: How Health Systems Are Failing to Comprehensively Address Child Mortality shows how the aid system is not responding to the causes of child mortality in a targeted manner. The international health agenda is failing …
Author: WaterAid America
- Future Directions for Research on Enterotoxigenic Escherichia coli Vaccines for Developing Countries
This article, published in the Weekly Epidemiological Record, reviews the progress made in enterotoxigenic Escherichia coli (ETEC) vaccine development and evaluates the current status of ETEC vaccine research for children in developing countries. It …
Author: World Health Organization
- Global Impact of Diarrheal Diseases That Are Sampled by Travelers: The Rest of the Hippopotamus
Travelers who experience diarrhea are exposed to the same pathogens and illnesses that pose some of the greatest threats to life and development among malnourished children in developing areas around the world, where inadequate water and poor …
Author: Guerrant RL, Oria R, Bushen OY, et al.
- High Disease Burden of Diarrhea Due to Enterotoxigenic Escherichia coli Among Rural Egyptian Infants and Young Children
Published in the Journal of Clinical Microbiology, this article examins the burden of diarrheal disease due to enterotoxigenic E. coli among rural Egyptian infants and young children, whic has an incidence of 1.5 episodes per child per …
Author: Rao M, Abu-Elyazeed R, Savarino S, et al.
- Immune Responses and Protection in Children in Developing Countries Induced by Oral Vaccines
Oral mucosal vaccines have great promise for generating protective immunity against intestinal infections for the benefit of large numbers of people especially young children. However, these vaccines are not equally immunogenic nor protective in …
Author: Qadri F, Bhuiyan TR, Sack DA, Svennerholm A-M
- Inactivated and Subunit Vaccines to Prevent Shigellosis
This article, published in Expert Review of Vaccines, describes how vaccines to prevent shigellosis can be divided into living and nonliving approaches. Several nonliving Shigella vaccines are currently at different stages of development and show …
Author: Kaminski RW, Oaks EV
- Increasing Access to Lifesaving Vaccines: PATH Closes the Immunization Gap Through Innovation and Collaboration
This fact sheet outlines PATH's work on vaccines and immunization. Topic areas include developing affordable vaccines, designing innovative vaccine technologies, and expanding uptake of existing vaccines. These efforts reduce the burden of malaria, …
- Innovation in Enteric Vaccine Development: Addressing Bacterial Causes of Diarrhea
This fact sheet describes PATH's enteric vaccine project from a technical perspective. It includes an overview of PATH's vaccine development portfolio, research activities, and partners to support the development of effective and affordable vaccines …
- An Integrated Approach to Confronting Diarrheal Disease
This briefing paper provides an overview of the tools and interventions involved with an integrated approach to diarrheal disease control, including vaccines, oral rehydration therapy, breastfeeding, and zinc treatment. The document also advocates …
- Intradermal Delivery of Vaccines: A Review of the Literature and the Potential for Development for Use in Low- and Middle-Income Countries
The purpose of this report is: (1) to summarize the clinical evidence supporting the intradermal route for vaccine administration and the devices being developed for this purpose; (2) to determine whether intradermal delivery broadly holds promise …
- Introducing New Vaccines Into Developing Countries: Obstacles, Opportunities, and Complexities
This commentary, published in Nature Medicine, reviews current trends that may affect whether the most promising of the 350 vaccine candidates under development will eventually be used in programs for the poor in developing countries. It also …
Author: Clemens J, Jodar L
- Landscape Analysis: Trends in Vaccine Availability and Novel Vaccine Delivery Technologies: 2008–2025
This landscape analysis identifies trends in the availability of vaccines and novel vaccine delivery technologies that are and will be of relevance to low- and middle-income countries from the present through 2025.
Author: PATH, World Health Organization
- Live-Attenuated Shigella Vaccines
This article, published in Expert Review of Vaccines, describes several live attenuated Shigella vaccines, with well-defined mutations in specific genes, that have shown great promise in eliciting significant immune responses when given orally to …
Author: Venkatesan MM, Ranallo RT
- Magnitude and Impact of Diarrheal Diseases
Published in The Archives of Medical Research, this article reviews the high costs of diseases of poverty, increasing diarrhea morbidity (despite decreasing mortality), and new emerging evidence for long-term consequences of early childhood …
Author: Guerrant RL, Kosek M, Moore S, et al.
- Microbial-Gut Interactions in Health and Disease: Progress in Enteric Vaccine Development
Published in Best Practice & Research in Clinical Gastroenterology, this article describes the properties and availability of recently licensed vaccines against enteric pathogens and present an update on the diverse efforts …
Author: Svennerholm AM, Steele D
- More About Shigellosis and Enterotoxigenic Escherichia coli (ETEC)
This web page on the Vaccine Resource Library provides a link to PATH's work on shigellosis and enterotoxigenic Escherichia coli (ETEC), as well as general information about the diseases and the current vaccine landscapes.
- A Multicenter Study of Shigella Diarrhea in Six Asian Countries: Disease Burden, Clinical Manifestations, and Microbiology
Published in PLoS Medicine, this article discusses a prospective, population-based study in six Asian countries to gain a better understanding of the current disease burden, clinical manifestations, and microbiology of shigellosis in Asia.
Author: von Seidlein L, Kim DR, Ali M, et al.
- New Strategies for Accelerating Shigella Vaccine Development
Published in Weekly Epidemiological Record, this report presents an update on research for Shigella vaccine development and the recommendations of a WHO meeting to accelerate the development of Shigella vaccines.
Author: World Health Organization
- New Vaccines Against Enteric Bacteria for Children in Less Developed Countries
This article, published in Expert Review of Vaccines, describes how the development of safe and effective multicomponent, whole-bacterial cell vaccine(s) against enterotoxigenic Escherichia coli and Shigella, two important pathogens for which no …
Author: Walker RI
- The Oral, Live Attenuated Enterotoxigenic Escherichia coli Vaccine ACE527 Reduces the Incidence and Severity of Diarrhea in a Human Challenge Model of Diarrheal Disease
This article, published in Clinical and Vaccine Immunology, presents findings from a Phase 2b challenge study of an oral, live attenuated, three-strain recombinant bacterial vaccine, ACE527, against enterotoxigenic Escherichia coli (ETEC). Fifty-six …
Author: Darsley MJ, Chakraborty S, DeNearing B, et al.
- Pneumonia and Diarrhoea: Tackling the Deadliest Diseases for the World’s Poorest Children
This report focuses on the huge potential to narrow the child survival gap between the richest and the poorest by focusing on pneumonia and diarrhea—the two primary killers of children under the age of five. It includes a review of the current …
Author: United Nations Children's Fund
- Policymakers Views Regarding the Introduction of New-Generation Vaccines Against Typhoid Fever, Shigellosis, and Cholera in Asia
Published in Vaccine, this article disusses face-to-face interviews and meetings with more than 160 policymakers and other influential professionals in seven large Asian countries (Bangladesh, China, India, Indonesia, Pakistan, Thailand and …
Author: DeRoeck D, Clemens JD, Nyamete A, Mahoney RT