Published in The Bulletin of the World Health Organization, this study provides estimates of diarrhea mortality at country, regional, and global levels and discusses interventions to reduce childhood mortality caused by diarrheal disease.

This article, from the Philosophical Transactions of the Royal Society B, provides a review of the enteric vaccines currently available and their lack of use in developing countries. The author purports that the reasons for this are multiple and …

WaterAid's report Fatal Neglect: How Health Systems Are Failing to Comprehensively Address Child Mortality shows how the aid system is not responding to the causes of child mortality in a targeted manner. The international health agenda is failing …

This article, published in the Weekly Epidemiological Record, reviews the progress made in enterotoxigenic Escherichia coli (ETEC) vaccine development and evaluates the current status of ETEC vaccine research for children in developing countries. It …

This protocol provides a generic outline for a study to assess local Shigella disease burden and describes the main procedures involved. However, it will need to be adapted to local settings, and details of field work and operational …

Travelers who experience diarrhea are exposed to the same pathogens and illnesses that pose some of the greatest threats to life and development among malnourished children in developing areas around the world, where inadequate water and poor …

Published in the Journal of Clinical Microbiology, this article examins the burden of diarrheal disease due to enterotoxigenic E. coli among rural Egyptian infants and young children, whic has an incidence of 1.5 episodes per child per …

Oral mucosal vaccines have great promise for generating protective immunity against intestinal infections for the benefit of large numbers of people especially young children. However, these vaccines are not equally immunogenic nor protective in …

This article, published in Expert Review of Vaccines, describes how vaccines to prevent shigellosis can be divided into living and nonliving approaches. Several nonliving Shigella vaccines are currently at different stages of development and show …

This fact sheet outlines PATH's work on vaccines and immunization. Topic areas include developing affordable vaccines, designing innovative vaccine technologies, and expanding uptake of existing vaccines. These efforts reduce the burden of malaria, …

This briefing paper provides an overview of the tools and interventions involved with an integrated approach to diarrheal disease control, including vaccines, oral rehydration therapy, breastfeeding, and zinc treatment. The document also advocates …

This commentary, published in Nature Medicine, reviews current trends that may affect whether the most promising of the 350 vaccine candidates under development will eventually be used in programs for the poor in developing countries. It also …

This landscape analysis identifies trends in the availability of vaccines and novel vaccine delivery technologies that are and will be of relevance to low- and middle-income countries from the present through 2025.

This article, published in Expert Review of Vaccines, describes several live attenuated Shigella vaccines, with well-defined mutations in specific genes, that have shown great promise in eliciting significant immune responses when given orally to …

Published in The Archives of Medical Research, this article reviews the high costs of diseases of poverty, increasing diarrhea morbidity (despite decreasing mortality), and new emerging evidence for long-term consequences of early childhood …

This report, published in the Weekly Epidemiological Record, provides a summary of the World Health Organization's Diarrhoeal and Enteric Vaccines Advisory Committee's (DEVAC) annual meeting in October 2008. DEVAC, a 12-member group of experts, …

Published in Best Practice & Research in Clinical Gastroenterology, this article describes the properties and availability of recently licensed vaccines against enteric pathogens and present an update on the diverse efforts …

This web page on the Vaccine Resource Library provides a link to PATH's work on shigellosis and enterotoxigenic Escherichia coli (ETEC), as well as general information about the diseases and the current vaccine landscapes.

Published in PLoS Medicine, this article discusses a prospective, population-based study in six Asian countries to gain a better understanding of the current disease burden, clinical manifestations, and microbiology of shigellosis in Asia.

Published in Weekly Epidemiological Record, this report presents an update on research for Shigella vaccine development and the recommendations of a WHO meeting to accelerate the development of Shigella vaccines.

This article, published in Expert Review of Vaccines, describes how the development of safe and effective multicomponent, whole-bacterial cell vaccine(s) against enterotoxigenic Escherichia coli and Shigella, two important pathogens for which no …

This fact sheet describes PATH's enteric vaccine project from a technical perspective. It includes an overview of PATH's vaccine development portfolio, research activities, and partners to support the development of effective and affordable vaccines …

This article, published in Clinical and Vaccine Immunology, presents findings from a Phase 2b challenge study of an oral, live attenuated, three-strain recombinant bacterial vaccine, ACE527, against enterotoxigenic Escherichia coli (ETEC). Fifty-six …

This report focuses on the huge potential to narrow the child survival gap between the richest and the poorest by focusing on pneumonia and diarrhea—the two primary killers of children under the age of five. It includes a review of the current …

Published in Vaccine, this article disusses face-to-face interviews and meetings with more than 160 policymakers and other influential professionals in seven large Asian countries (Bangladesh, China, India, Indonesia, Pakistan, Thailand and …