In 2010, Burkina Faso conducted a country-wide campaign to introduce a new Group A meningococcal conjugate vaccine, MenAfriVac™. Leading up to this effort, the following challenges were successfully managed: (1) conducting a large safety study …

Few Asian countries have introduced Haemophilus influenzae type b (Hib) conjugate vaccine because of its cost and uncertainty regarding disease burden. To estimate the effectiveness of Hib conjugate vaccine in preventing pneumonia and meningitis in …

Young infants and pregnant women are at increased risk for serious consequences of influenza infection. Inactivated influenza vaccine is recommended for pregnant women but is not licensed for infants younger than six months of age. This study …

Correspondence, published in the New England Journal of Medicine, about a small case control study in Uttar Pradesh, India, on the efficacy of a single dose of the SA 14-14-2 JE vaccine within six months of its administration. …

This document provides a literature review of articles about the effects of freezing on vaccine potency of hepatitis B, tetanus toxoid, diphtheria, and pertussis vaccines. Also included is a review of stability data of …

This study, published in the New England Journal of Medicine, enrolled 1662 infants in a randomized, double-blind efficacy trial of a heptavalent pneumococcal polysaccharide conjugate vaccine in which the carrier protein is the nontoxic …

This article, published in The Lancet, presents data that show high efficacy for GSK's Rotarix® administered with routine vaccines. Over two seasons, Rotarix® demonstrated 90 percent efficacy against severe rotavirus among European …

Published in The Lancet, this study aims to assess the efficacy of a nine-valent pneumococcal conjugate vaccine in children through a randomised, placebo-controlled, double-blind trial in eastern Gambia. Children age 6–51 weeks were randomly …

This article, published in The Lancet, assesses the clinical efficacy of the pentavalent, live oral rotavirus vaccine for the prevention of severe rotavirus gastroenteritis in infants in Bangladesh and Vietnam. Study results demonstrated vaccine …

This article, published in The Lancet, shares results of an efficacy study of the pentavalent, live oral rotavirus vaccine in Ghana, Kenya, and Mali. Results showed 39.3 percent efficacy against  severe rotavirus gastroenteritis. The authors …

Pneumococcal conjugate vaccines have shown a high degree of success in preventing pneumococcal bacteraemia in children. They also reduce the acquisition of carriage of vaccine serotypes in the nasopharynx, and reduce otitis media caused by those …

This study, published in the New England Journal of Medicine, evaluated the efficacy of the RTS,S malaria vaccine given with a more immunogenic adjuvant system (AS01E) than one used in a previous study (AS02A). The study was conducted in …

This study, published in the Journal of Infectious Diseases, determined that the Rotarix® vaccine produced by GlaxoSmithKline decreased the incidence severe gastroenteritis caused by rotavirus at comparable rates among well-nourished and …

This article, published in Health Affairs, discusses a new affordable vaccine against Group A meningococcus, the most common cause of large and often fatal African epidemics of meningitis, that was introduced in Burkina Faso, Mali, and Niger in …

Routine immunization of infants in The Gambia with a Haemophilus influenzae type b (Hib) polysaccharide-tetanus toxoid conjugate vaccine began in May 1997. This article, published in The Lancet, reports on a study that investigated the effectiveness …

This article provides a comprehensive overview of the disease.

This article, published in the New England Journal of Medicine, describes the findings of the US Centers for Disease Control and Prevention's Novel Swine-Origin Influenza A(H1N1) Virus Investigation Team from their assessment of the …

In this article, published in the Journal of Clinical Microbiology, researchers identified a broad diversity of rotavirus strains among children in India, including several unusual strains and two novel strains. The study highlights the great …

This comment, published in The Lancet, is based on a review of the study "Emergency Vaccination Against Epidemic Meningitis in Ghana: Implications for the Control of Meningococcal Disease in West Africa." The author concludes that …

This article, published in The Lancet, assessed the potential effects of different vaccination strategies against meningococcal disease using data from the 1997 meningococcal outbreak in northern Ghana. Using a simple mathematical model, …

This chapter from an annual report explores why licensure of the vaccine against human papillomavirus (HPV) presents the AIDS vaccine field with new opportunities. The report discusses how to advocate for financing commitments to ensure widespread …

The authors of this study, published in Vaccine, compared formalin-inactivated (FI) RSV, purified F glycoprotein in alum, and RSV infection (intranasal) for their immunogenicity, efficacy, and ability to enhance pulmonary histopathology during RSV …

This article, published in the Bulletin of the World Health Organization, describes avenues for service delivery of human papillomavirus (HPV) vaccines and critical information gaps that must be bridged in order to inform future sexual and …

According to this article published in the eJournal Innovation Strategies Today, product development partnerships (PDPs) are generating an increasing flow of health products, including vaccines, for diseases prevalent in developing countries. …

This web page provides information in enteric diseases, including NIAID-supported research, meeting summaries, news releases, and resources for researchers.