This article, published in Vaccine, reports on a study of the potency of monovalent oral polio vaccine type 3 kept at ambient temperatures during a polio immunization campaign in Chad. The results of the study show that post-campaign …

This article, published in Human Vaccines, reports on a study that aimed to characterize the immediate qualitative changes of hepatitis B vaccine caused by freeze exposure. The vaccine was subjected to freezing temperatures ranging from 0°C to …

Optimize—a collaboration between the World Health Organization and PATH—aims to employ technological and scientific advances by defining ideal specifications for health products and creating a flexible and robust vaccine supply chain …

This article, published in Procedia in Vaccinology, discusses the importance of designing vaccines with traits that will minimize complications for immunization programs and increase the likelihood of successful adoption. The article also summarizes …

This article, published in the Journal of Pharmaceutical Sciences, discusses the opportunities and challenges associated with developing vaccines with desirable attributes, including enhanced stability and efficient packaging, that can help to …

Facilitated by project Optimize and conducted by a multidisciplinary group of partners, these landscape analyses highlight ongoing work related to five priority areas that comprise the vision for immunization supply systems in 2020. The analyses …

This article, published in Vaccine, describes an approach to minimize reliance on the proper implementation of the cold chain to protect vaccines from freeze-thaw inactivation. By including PEG 300, propylene glycol, or glycerol in a hepatitis …

This fact sheet describes how PATH and the US Department of Defense (DOD) collaborate to enhance the health of the world’s poorest people and presents a sampling of PATH projects, including work on vaccines to prevent diarrhea and vaccine …

This article, published in Vaccine, evaluates the incremental health and programmatic cost impacts of theoretical new vaccine products as compared to the standard vaccine products in multi-dose vials in Cambodia, Ghana, and Bangladesh. The authors …

This document provides a literature review of articles about the effects of freezing on vaccine potency of hepatitis B, tetanus toxoid, diphtheria, and pertussis vaccines. Also included is a review of stability data of …

This document provides a literature review of articles about evidence of vaccine freezing in the cold chain. The document is part of a series that describes the serious risk of freezing vaccines and World Health …

This analysis, published in the journal Vaccine, highlights the pervasiveness of accidental freezing across the cold chain and makes recommendations for addressing the problem. ABSTRACT ONLY. (Learn how users in developing countries can gain free …

This article, published in Human Vaccines, discusses a study to develop a formulation of recombinant hepatitis B vaccine with improved stability at elevated temperatures. A new vaccine formulation has the potential to be used outside the cold chain …

This article, published in Vaccine, reports on the development of a heat-stable measles vaccine powder using a combination of unique stabilizers and mild spray-drying process conditions. The researchers identified spray drying as the optimal …

This study, published in the Bulletin of the World Health Organization, aimed to document and characterize freezing temperatures in the Indonesian vaccine cold chain to evaluate the feasibility of changes designed to reduce the occurrence of …

This entire issue of the Bulletin of the World Health Organization is devoted to the topic of immunization safety, including vaccine quality, adverse events reporting, and safety of immunization injections.

PATH recently developed a mucosal immunization technology platform--viable in two formats--that builds on several proven formulation, adjuvant, and delivery technologies that enable the efficient sublingual administration of subunit vaccines. Part …

This article, published in Expert Review of Vaccines, reviews approaches being used to develop thermostable vaccine formulations that are resistant to damage caused by freezing or excessive heat and could reduce dependence on the cold …

The Op.ti.mize e-newsletter is a quarterly publication that highlights advances and innovations in health care logistics, technologies, and policy. Developed by Project Optimize, a collaboration between the World Health Organization and PATH, this …

This fact sheet describes how PATH developed a low-cost and straightforward technology for protecting aluminum-adjuvanted liquid vaccines from the irreversible damage that results from freezing. Many current vaccines of importance to global …

This protocol is designed to document the level of freezing in the cold chain and identify specific problem areas where corrective actions are warranted. It can be tailored to an individual program’s resources: a simple, low-cost study can be …

The Optimize project, a collaboration between PATH and the World Health Organization, commissioned this white paper to examine the issues influencing vaccine producer willingness to advance, adopt, and commercialize value-added technologies for …

This fact sheet discusses PATH's work on the development and implementation of technologies, such as vaccines and vaccine delivery devices, to improve the health of women and children in poor and remote areas around the world.

This article, published in Biologicals, discusses why stability studies are important tools to reliably ensure that the efficacy and safety of medicinal products remain unchanged from release of drug product until the end of shelf life. The author …

This editorial, published in Human Vaccines, explores the key logistical, regulatory, procurement, and policy issues associated with the development and use of temperature-stabilized vaccines. The authors reflect on nearly 8 years of work to …