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Topic: Vaccine stabilization

Total results with these characteristics: 44

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Above Zero: Strategies to Prevent Vaccine Freezing

This four-minute animated video emphasizes the difficulty and importance of maintaining proper temperatures in the vaccine cold chain. The risk of exposing vaccines to freezing temperatures are now known to be significant. These risks can be reduced …

Author: PATH, World Health Organization

Published: 2013

Assessing the Potency of Oral Polio Vaccine Kept Outside of the Cold Chain During a National Immunization Campaign in Chad

This article, published in Vaccine, reports on a study of the potency of monovalent oral polio vaccine type 3 kept at ambient temperatures during a polio immunization campaign in Chad. The results of the study show that post-campaign laboratory …

Author: Zipursky S, Boualam L, Cheikh DO, et al.

Published: 2011

Characterization of a Thermostable Hepatitis B Vaccine Formulation

This article, published in the journal Vaccine, reports on the development of a new hepatitis B vaccine formulation that is stable against repeated freezing at -20°C and is also stable for 12 months at 37°C. The improved stability of this …

Author: Braun LJ, Jezek J, Peterson S, et al.

Published: 2009

Characterization of the Freeze Sensitivity of a Hepatitis B Vaccine

This article, published in Human Vaccines, reports on a study that aimed to characterize the immediate qualitative changes of hepatitis B vaccine caused by freeze exposure. The vaccine was subjected to freezing temperatures ranging from 0°C to …

Author: Chen D, Tyagi A, Carpenter J, et al.

Published: 2009

Designing Vaccines for Developing-Country Populations: Ideal Attributes, Delivery Devices, and Presentation Formats

This article, published in Procedia in Vaccinology, discusses the importance of designing vaccines with traits that will minimize complications for immunization programs and increase the likelihood of successful adoption. The article also summarizes …

Author: Kristensen D, Zaffran M

Published: 2010

Desirable Attributes of Vaccines for Deployment in Low-Resource Settings

This article, published in the Journal of Pharmaceutical Sciences, discusses the opportunities and challenges associated with developing vaccines with desirable attributes, including enhanced stability and efficient packaging, that can help to …

Author: Chen D, Zehrung D

Published: 2013

Developing a Vision for Immunization Supply Systems in 2020: Landscape Analysis Summaries

Facilitated by project Optimize and conducted by a multidisciplinary group of partners, these landscape analyses highlight ongoing work related to five priority areas that comprise the vision for immunization supply systems in 2020. The analyses …

Author: PATH, World Health Organization

Published: 2011

Development of a Freeze-Stable Formulation for Vaccines Containing Aluminum Salt Adjuvants

This article, published in Vaccine, describes an approach to minimize reliance on the proper implementation of the cold chain to protect vaccines from freeze-thaw inactivation. By including PEG 300, propylene glycol, or glycerol in a hepatitis B …

Author: Jones Braun L, Tyagi A, Perkins S, et al.

Published: 2009

DOD and PATH: Collaborations Enhance Health for the World's Poorest People

This fact sheet describes how PATH and the US Department of Defense (DOD) collaborate to enhance the health of the world’s poorest people and presents a sampling of PATH projects, including work on vaccines to prevent diarrhea and vaccine …

Author: PATH

Published: 2012

An Economic Evaluation of Thermostable Vaccines in Cambodia, Ghana, and Bangladesh

This article, published in Vaccine, evaluates the incremental health and programmatic cost impacts of theoretical new vaccine products as compared to the standard vaccine products in multi-dose vials in Cambodia, Ghana, and Bangladesh. The authors …

Author: Levin A, Levin C, Kristensen D, Matthias D

Published: 2007

Effects of Freezing on Vaccine Potency: Literature Review

This document provides a literature review of articles about the effects of freezing on vaccine potency of hepatitis B, tetanus toxoid, diphtheria, and pertussis vaccines. Also included is a review of stability data of these vaccines at …

Author: PATH

Published: 2003

Evidence of Vaccine Freezing in the Cold Chain: Literature Review

This document provides a literature review of articles about evidence of vaccine freezing in the cold chain. The document is part of a series that describes the serious risk of freezing vaccines and World Health Organization-recommended …

Author: PATH

Published: 2003

Exposure to Heat and Freezing in the Vaccine Cold Chain in Thailand

Good cold chain practice is essential to maintain full immunogenicity of vaccines. This article, published in Vaccine, reports on a study that aimed to identify the likelihood and extent of exposure to inappropriate temperatures in the vaccine cold …

Author: Techathawat S, Varinsathien P, Rasdjarmrearnsook A, Tharmaphornpilas P

Published: 2006

Freeze-Protection of Aluminum-Adjuvanted Vaccines: PATH Formulation Technology

PATH has developed a low-cost and straightforward approach for protecting aluminum-adjuvanted vaccines from irreversible damage that results from freezing. Many current vaccines of importance to global health contain an aluminum-salt adjuvant (such …

Author: PATH

Published: 2014

Freezing Temperatures in the Vaccine Cold Chain: A Systematic Literature Review

This analysis, published in the journal Vaccine, highlights the pervasiveness of accidental freezing across the cold chain and makes recommendations for addressing the problem. ABSTRACT ONLY. (Learn how users in developing countries can gain free …

Author: Matthias DM, Robertson J, Garrison MM, Newland S, Nelson C

Published: 2007

A Heat-Stable Hepatitis B Vaccine Formulation

This article, published in Human Vaccines, discusses a study to develop a formulation of recombinant hepatitis B vaccine with improved stability at elevated temperatures. A new vaccine formulation has the potential to be used outside the cold chain …

Author: Jezek J, Chen D, Watson L, et al.

Published: 2009

Heat-Stable Measles Vaccine Produced by Spray Drying

This article, published in Vaccine, reports on the development of a heat-stable measles vaccine powder using a combination of unique stabilizers and mild spray-drying process conditions. The researchers identified spray drying as the optimal …

Author: Ohtake S, Martin RA, Yee L, et al.

Published: 2010

Hepatitis B Vaccine Freezing in the Indonesian Cold Chain: Evidence and Solutions

This study, published in the Bulletin of the World Health Organization, aimed to document and characterize freezing temperatures in the Indonesian vaccine cold chain to evaluate the feasibility of changes designed to reduce the occurrence of …

Author: Nelson C, et al

Published: 2004

Immunization Safety: A Global Priority

This entire issue of the Bulletin of the World Health Organization is devoted to the topic of immunization safety, including vaccine quality, adverse events reporting, and safety of immunization injections.

Author: World Health Organization

Published: 2000

Improving the Reach of Vaccines to Low-Resource Regions, With a Needle-Free Vaccine Delivery Device and Long-Term Thermostabilization

In this article, published in the Journal of Controlled Release, the authors describe how dry-coated microprojections, a needle-free vaccine delivery device, can deliver vaccine to abundant antigen-presenting cells in the skin and induce efficient …

Author: Chen X, Fernando GJP, Crichton ML, et al.

Published: 2011

Mucosal Immunization Technologies

PATH developed a mucosal immunization technology platform--viable in two formats--that builds on several proven formulation, adjuvant, and delivery technologies that enable the efficient sublingual administration of subunit vaccines. Part of PATH's …

Author: PATH

Published: 2013

Opportunities and Challenges of Developing Thermostable Vaccines

This article, published in Expert Review of Vaccines, reviews approaches being used to develop thermostable vaccine formulations that are resistant to damage caused by freezing or excessive heat and could reduce dependence on the cold …

Author: Chen D, Kristensen D

Published: 2009

Op.ti.mize

The Op.ti.mize e-newsletter is a quarterly publication that highlights advances and innovations in health care logistics, technologies, and policy. Developed by Project Optimize, a collaboration between the World Health Organization and PATH, this …

Author: PATH, World Health Organization

Preventing Vaccine Freezing in the Cold Chain

Vaccine freezing in the cold chain is increasingly recognized as a serious threat to immunization programs. This zipped set of materials includes background information on the freezing problem (two literature reviews and a PowerPoint presentation); …

Author: PATH

Published: 2003

Protecting Aluminum-Adjuvanted Vaccines From Freeze Damage

This fact sheet describes how PATH developed a low-cost and straightforward technology for protecting aluminum-adjuvanted liquid vaccines from the irreversible damage that results from freezing. Many current vaccines of importance to global …

Author: PATH

Published: 2012

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