These action plans describe specific activities and strategies designed to help achieve the common vision for the future of immunization supply systems developed by the Cold Chain and Logistics Task Force (led by the United Nations Children’s …

This fact sheet describes the positive impact that adjuvants can have on vaccine efficacy and, potentially, immunization program costs. It also describes PATH’s work to expand global access to proprietary and non-proprietary adjuvants as well …

The positive impact of adjuvants on vaccination can be functional and practical. A handful of adjuvants are currently licensed for human vaccination, and a number of new adjuvants have reached advanced development stages. However, access to these …

This report highlights a study that uses a breakeven cost analysis to compare potential prices, wastage rates, and cold chain requirements for various human papillomavirus vaccine presentations. The results of this study provide insight into …

Project Optimize undertook a cost-comparison case study of five container options for vaccine transport from the national to the regional level in Senegal. This report may be used as a starting point for other country vaccine programs weighing …

This article, published in Procedia in Vaccinology, discusses the importance of designing vaccines with traits that will minimize complications for immunization programs and increase the likelihood of successful adoption. The article also summarizes …

This article, published in the Journal of Pharmaceutical Sciences, discusses the opportunities and challenges associated with developing vaccines with desirable attributes, including enhanced stability and efficient packaging, that can help to …

Facilitated by project Optimize and conducted by a multidisciplinary group of partners, these landscape analyses highlight ongoing work related to five priority areas that comprise the vision for immunization supply systems in 2020. The analyses …

This article, published in Vaccine, evaluates the incremental health and programmatic cost impacts of theoretical new vaccine products as compared to the standard vaccine products in multi-dose vials in Cambodia, Ghana, and Bangladesh. The authors …

This document provides guidance to the vaccine industry and other vaccine development groups on preferred presentations and packaging for vaccines intended for public‐sector use in developing countries. This generic preferred product profile …

This excellent, comprehensive training manual addresses and answers important questions about using VVMs in the field.

This excellent, 112-page manual is a training curriculum for health care workers who provide injections. It includes information on the health impact of unsafe injections, selecting safe and effective vaccines, reconsituting vaccines safely, reading …

This widely used reference from WHO has been updated according to new developments in vaccine stability, temperature monitoring, and recently pre-qualified vaccines.

A major problem in immunization programs throughout the world has been the challenge of monitoring and managing the temperature of vaccines as they travel through the distribution chain to the destinations where they are used. This report …

This document describes the partnership that created the vaccine vial monitor, providing a useful example to policymakers, funders, nongovernmental and multilateral organizations, and product developers of how the public and private sectors can …

This fact sheet provides an overview of PATH's work to develop and deliver innovative health solutions for those who need them most. These solutions range from developing and introducing affordable, appropriate technologies to creating conditions …

The purpose of this report is: (1) to summarize the clinical evidence supporting the intradermal route for vaccine administration and the devices being developed for this purpose; (2) to determine whether intradermal delivery broadly holds promise …

The Op.ti.mize e-newsletter is a quarterly publication that highlights advances and innovations in health care logistics, technologies, and policy. Developed by Project Optimize, a collaboration between the World Health Organization and PATH, this …

Optimize, a collaboration between the World Health Organization and PATH, has been given a unique mandate to think far into the future: to put technological and scientific advances to work, helping define the ideal characteristics and …

This report presents the results of demonstration projects and other activities undertaken in Senegal from 2009 to 2012 as part of a partnership between project Optimize and the Senegalese Ministry of Health. The activities aimed to demonstrate …

This document provides a brief overview of the Optimize project's strategy for developing delivery systems that are as advanced and innovative as the vaccines they support. Optimize, a collaboration between the World Health Organization and …

This report presents the results of demonstration projects and other activities undertaken in Vietnam as part of a partnership between project Optimize and Vietnam’s Ministry of Health. The activities aimed to demonstrate innovations in …

This fact sheet describes how PATH developed a low-cost and straightforward technology for protecting aluminum-adjuvanted liquid vaccines from the irreversible damage that results from freezing. Many current vaccines of importance to global …

The Optimize project, a collaboration between PATH and the World Health Organization, commissioned this white paper to examine the issues influencing vaccine producer willingness to advance, adopt, and commercialize value-added technologies for …

This job aid illustrates how to read time-temperature indicators with the Uniject® device, which is an autodisable, prefilled, single-use syringe that can be used with vaccines.