Disease: Respiratory syncytial virus (RSV)
Total results with these characteristics: 39
- Acute Respiratory Infections (Update September 2009): Respiratory Syncytial Virus and Parainfluenza Viruses
This web page offers an overview of respiratory syncytial virus and parainfluenza viruses, detailing disease burden, virology, and vaccines from a global perspective. The annotated text included provides links to additional …
Author: World Health Organization
- Biological Challenges and Technological Opportunities for Respiratory Syncytial Virus Vaccine Development
This article, published in Immunological Reviews, provides an overview of the barriers that have challenged and delayed the development of vaccines against respiratory syncytial virus (RSV) and identifies opportunities that could help overcome these …
Author: Graham B
- Challenges in Developing a Pediatric RSV Vaccine
There is currently no approved respiratory syncytial virus (RSV) vaccine, and the goal of preventing RSV-associated illness in the general population remains unmet. The authors of this article, published in Human Vaccines, discuss the challenges …
Author: Schickli JH, Dubovsky F, Tang RS
- Cotton Rats Previously Immunized With a Chimeric RSV FG Glycoprotein Develop Enhanced Pulmonary Pathology When Infected With RSV, a Phenomenon not Encountered Following Immunization With Vaccinia-RSV Recombinants or RSV
In studies conducted in the 1960s, children previously immunized with a formalin-inactivated respiratory syncytial virus (RSV) vaccine (FI-RSV) developed a greater incidence and severity of pulmonary disease during subsequent natural RSV infection …
Author: Connors M, Collins PL, Firestone CY, et al.
- Development of a Humanized Monoclonal Antibody (MEDI-493) With Potent In Vitro and In Vivo Activity Against Respiratory Syncytial Virus
This article, published in The Journal of Infectious Diseases, details a preclinical study evaluating the ability of a humanized monoclonal antibody, MEDI-493 (later named palivizumab and marketed at Synagis®), to recognize a conserved …
Author: Johnson S, Oliver C, Prince GA, et al.
- Dissociation Between Serum Neutralizing and Glycoprotein Antibody Responses of Infants and Children Who Received Inactivated Respiratory Syncytial Virus Vaccine
In the 1960s a respiratory syncytial virus (RSV) vaccine was evaluated in infants and young children. Vaccinees who received formalin-inactivated RSV during early infancy developed more serious lower-respiratory-tract disease when infected with the …
Author: Murphy BR, Prince GA, Walsh EE, et al.
- Enhanced Pulmonary Histopathology is Observed in Cotton Rats Immunized with Formalin-Inactivated Respiratory Syncytial Virus (RSV) or Purified F Glycoprotein and Challenged With RSV 3-6 Months After Immunization
The authors of this study, published in Vaccine, compared formalin-inactivated (FI) RSV, purified F glycoprotein in alum, and RSV infection (intranasal) for their immunogenicity, efficacy, and ability to enhance pulmonary histopathology during RSV …
Author: Murphy BR, Sotnikov AV, Lawrence LA, Banks SM, Prince GA
- An Epidemiologic Study of Altered Clinical Reactivity to Respiratory Syncytial (RS) Virus Infection in Children Previously Vaccinated With an Inactivated RS Virus Vaccine
This article, published in the American Journal of Epidemiology, describes a study that evaluated altered clinical reactivity to a formalin-inactivated respiratory syncytial virus (RSV) vaccine candidate administered to healthy infants and children …
Author: Kapikian AZ, Mitchell RH, Chanock RM, Shvedoff RA, Stewart CE
- Epidemiology, Aetiology and Management of Childhood Acute Community-Acquired Pneumonia in Developing Countries--A Review
This article, published in the African Journal of Medicine and Medical Sciences, provides an overview of the causes of clinical pneumonia in developing countries, available vaccines for fighting pneumonia, and efforts underway and planned to expand …
Author: Falade AG, Ayede AI
- An Evaluation of the Emerging Interventions Against Respiratory Syncytial Virus (RSV)-Associated Acute Lower Respiratory Infections in Children
This article, published in BMC Public Health, summarizes the results of a literature review and an expert opinion exercise to evaluate the best course of protection against respiratory syncytial virus (RSV) for children in the developing world, …
Author: Nair H, Verma VR, Theodoratou E, et al.
- Field Evaluation of a Respiratory Syncytial Virus Vaccine and a Trivalent Parainfluenza Virus Vaccine in a Pediatric Population
This article, published the American Journal of Epidemiology, describes a field study conducted in California, United States, that evaluated two formalin inactivated respiratory virus vaccines, a respiratory syncytial virus (RSV) vaccine and a …
Author: Chin J, Magoffin RL, Shearer LA, Schieble JH, Lennette EH
- Global Burden of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Young Children: A Systematic Review and Meta-analysis
This article, published in The Lancet, describes research to estimate the global incidence of and mortality from episodes of acute lower respiratory infection (ALRI) due to respiratory syncytial virus (RSV) in children younger than five years …
Author: Nair H, Nokes DJ, Gessner BD, et al.
- Hot Topics in the Prevention of Respiratory Syncytial Virus Disease
This article, published in Expert Review of Vaccines, summarizes the proceedings from the 7th International Respiratory Syncytial Virus (RSV) Symposium, which convened approximately 200 clinicians, scientists, and industry representatives from …
Author: Habibi MS, Patel S, Openshaw P
- Increasing Access to Lifesaving Vaccines: PATH Closes the Immunization Gap Through Innovation and Collaboration
This fact sheet outlines PATH's work on vaccines and immunization. Topic areas include developing affordable vaccines, designing innovative vaccine technologies, and expanding uptake of existing vaccines. These efforts reduce the burden of malaria, …
- Jordan Report: Accelerated Development of Vaccines 2012
This comprehensive report includes expert articles on a variety of vaccine-related topics and updates on vaccine research for specific infectious diseases, such as influenza, malaria, respiratory syncytial virus, and rotavirus.
Author: US National Institute of Allergy and Infectious Diseases
- Maternal Immunization Against Viral Disease
This article, published in Vaccine, discusses the advantages and disadvantages of maternal immunization to augment the protective effect of maternal antibody against many viral diseases in the young infant. The authors also present more specific …
Author: Englund J, Glezen WP, Piedra PA
- More About Respiratory Syncytial Virus (RSV)
This web page from the Vaccine Resource Library provides a link to information about PATH's work on respiratory syncytial virus (RSV) as well as general information about RSV and a snapshot of the current RSV vaccine landscape.
- Neutralizing Antibodies Against the Preactive Form of Respiratory Syncytial Virus Fusion Protein Offer Unique Possibilities for Clinical Intervention
The only specific treatment available today against human respiratory syncytial virus (hRSV) is a humanized monoclonal antibody (Palivizumab) directed against the F glycoprotein, administered prophylactically to children at very high risk of severe …
Author: Magro M, Mas V, Chappell K, et al.
- Passive Protection Against Respiratory Syncytial Virus Disease in Infants: the Role of Maternal Antibody
Respiratory syncytial virus (RSV) is responsible for serious respiratory disease in young infants. The authors of this article, published in The Pediatric Infectious Disease Journal, discuss the importance of maternal antibody in the immunity …
Author: Englund JA
- Paving the Way for Respiratory Syncytial Virus Prevention: Vaccine Development Against a Widespread Cause of Respiratory Illness in Infants and Young Children
This fact sheet highlights PATH's work to develop a vaccine against respiratory syncytial virus (RSV) with the potential to help control RSV in the developing world through prevention.
This fact sheet provides an overview of the causes, means of transmission, symptoms, risk factors, treatment, prevention, and economic costs of pneumonia. Also outlined is the World Health Organization's action plan to prevent and treat pneumonia, …
Author: World Health Organization
- Prenatal Prevention of Respiratory Syncytial Virus Bronchiolitis
The authors of this article, published in Expert Review of Anti-infective Therapy, discuss how pregnancy may provide a unique window of opportunity for interventions aimed at preventing severe respiratory syncytial virus (RSV) infection in the …
Author: Belderbos M, Kimpen JLL, Bont L
- Prevention of Serious Respiratory Syncytial Virus-Related Illness. I: Disease Pathogenesis and Early Attempts at Prevention
This article, published in Advances in Therapy, provides an overview of the pathogenesis of respiratory syncytial virus (RSV), the historical challenges facing RSV vaccine development, and current technologies being explored to prevent RSV disease. …
Author: Groothuis JR, Hoopes JM, Hemming VG
- Prevention of Serious Respiratory Syncytial Virus-Related Illness. II: Immunoprophylaxis
This article, published in Advances in Therapy, reviews the development and use of palivizumab, the only drug approved for the prevention of respiratory syncytial virus (RSV) lower respiratory tract disease. Palivizumab is a monoclonal antibody that …
Author: Groothuis JR, Hoopes JM, Hemming VG
- Protecting Aluminum-Adjuvanted Vaccines From Freeze Damage
This fact sheet describes how PATH developed a low-cost and straightforward technology for protecting aluminum-adjuvanted liquid vaccines from the irreversible damage that results from freezing. Many current vaccines of importance to global …