This analysis, published in the The Lancet Infectious Diseases, applied data collected through the World Health Organization's Global Rotavirus Surveillance Network to update the estimate of childhood rotavirus mortality worldwide. The …

Investigators collected stool specimens from Ghanian children with acute gastroenteritis and determined that rotavirus was the most predominant cause in urban northern Ghana. This article was published in BMC Infectious Diseases.

This article, published in Morbidity and Mortality Weekly Report, reports on the revision that the US Food and Drug Administration has approved for the prescribing information and patient labeling for rotavirus vaccines manufactured by …

In response to reported cases of vaccine-acquired rotavirus infection in infants with severe combined immunodeficiency (SCID) following rotavirus vaccine administration, both Merck & Co. and GlaxoSmithKline Biologicals have revised …

This study, published in the journal Pediatrics, reviews cases presented to the Vaccine Adverse Event Reporting System in order to determine whether severe adverse events other than intussusception occurred after vaccination with an …

This editorial, published in the Pan American Journal of Public Health, supports accelerated vaccine introduction and provides information on health inequities, program sustainability, and vaccine affordability.

This article, published by the American Pharmacists Association, addresses the safety of rotavirus vaccines, including the latest information on possible contamination issues. The authors indicate that the documented benefits of RotaTeq and …

This article, published in the Journal of the American Medical Association, summarizes the first study to assess the impact of rotavirus vaccination in a developing country. The authors concluded that the vaccine could have a substantial impact on …

This article, published in Vaccine, reports on a study that assessed the potential benefits of mortality reduction versus the risk of fatal intussusception when (a) the first dose of rotavirus vaccine was administered by 12 weeks of age compared …

This report summarizes the objectives of PATH's now-inactive Children's Vaccine Program, highlighting the program's earlier activities in several countries in Africa and Asia aimed at increasing access to livesaving vaccines.

To assess the potential impact of rotavirus vaccines in sub-Saharan Africa, researchers reviewed recent published data on rotavirus burden among children aged five years old and circulating serotypes in sub-Saharan Africa. Though many countries …

This study, published in BMC Public Health, assesses the health outcomes and the economic impact of a universal rotavirus vaccination program with RotaTeq, a pentavalent rotavirus vaccine, against a no vaccination program in Spain. The study …

This article, published in Nature Medicine, reviews current successful vaccines and identifies their mechanisms of protection in the hopes of tackling the challenges posed by those infectious targets that have thus far escaped successful …

This retrospective analysis, published in the Medical Journal of Australia, found a sustained and substantial decline in rotavirus hospitalizations as well as hospitalizations for diarrhea of any cause following national vaccine …

After a multicenter study in several European countries, investigators determined that acute gastroenteritis caused by rotavirus resulted in more hospitalizations and emergency department visits than acute gastroenteritis from another cause. This …

This briefing paper underscores the burden of rotavirus disease and highlights the promise of vaccines to combat the virus as the global health community prepares for worldwide introduction.

This article, published in BMC Medicine, critically reviews available cost-effectiveness models for rotavirus vaccination, comparing their designs using a standardized approach and studying the similarities and differences in cost-effectiveness …

This fact sheet highlights PATH's work to address rotavirus and includes general information about its efforts to increase access to and effectiveness of existing vaccines, as well as to develop new vaccines.

The authors of this article, published in PLoS ONE, applied cost-effectiveness modeling and a cold-chain impact assessment to aid decision-making on rotavirus vaccine introduction in Kenya. They conclude that use of either vaccine is cost-effective, …

This report from the WHO's Weekly Epidemiologic Record summarizes a meeting convened by PATH, WHO, and the US Centers for Disease Control and Prevention (CDC) on the economic burden of rotavirus disease and cost-effectiveness of vaccines. The …

This study, published in the journal Pediatrics, examines the costs and benefits of routine rotavirus vaccination for infants in the US, using a hypothetical cohort of unvaccinated infants. Researchers determined that, at current prices, …

This paper, published in the journal Vaccine, investigates whether routine infant immunization with either currently licensed rotavirus vaccine could be cost-effective in Taiwan. The authors modeled specific disease outcomes …

This study, published in BMC Infectious Diseases, developed a model to compare the cost and disease burden of rotavirus in unvaccinated children in Mexico. The study determined that it would be highly cost-effective to include rotavirus vaccine …

This article, published in Vaccine, evaluates the cost-effectiveness of introducing infant rotavirus vaccination in Armenia in 2012 using Rotarix(R)® using a multiple birth cohort model. The model considered the cost and health implications of …

Investigators found that rotavirus gastroenteritis incurs considerable use of health care resources and results in substantial costs for families of patients and employers. Routine rotavirus vaccination could significantly reduce the related …