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Disease: Rotavirus

Total results with these characteristics: 241

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2008 Estimate of Worldwide Rotavirus-Associated Mortality in Children Younger than 5 Years Before the Introduction of Universal Rotavirus Vaccination Programmes: A Systematic Review and Meta-analysis

This analysis, published in the The Lancet Infectious Diseases, applied data collected through the World Health Organization's Global Rotavirus Surveillance Network to update the estimate of childhood rotavirus mortality worldwide. The …

Author: Tate JE, Burton AH, Boschi-Pinto C, Steele AD, Duque J, Parashar UD

Published: 2011

2013 Rota Roundup

2013 was a remarkable year for rotavirus vaccines, the best tool to prevent severe rotavirus disease and the deadly, dehydrating diarrhea that it causes. This infographic depicts various rotavirus vaccine highlights from the year, including the …

Author: PATH

Published: 2014

Accelerating the Development of New Rotavirus Vaccines

This fact sheet provides a technical perspective of PATH's work on rotavirus vaccines for children in the developing world. It includes an overview of PATH's efforts to increase access to and effectiveness of existing rotavirus vaccines, as well as …

Author: PATH

Published: 2014

Acute Childhood Diarrhoea in Northern Ghana: Epidemiological, Clinical, and Microbiological Characteristics

Investigators collected stool specimens from Ghanian children with acute gastroenteritis and determined that rotavirus was the most predominant cause in urban northern Ghana. This article was published in BMC Infectious Diseases.

Author: Reither K, Ignatius R, Weitzel T, et al.

Published: 2007

Addition of History of Intussusception as a Contraindication for Rotavirus Vaccination

This article, published in Morbidity and Mortality Weekly Report, reports on the revision that the US Food and Drug Administration has approved for the prescribing information and patient labeling for rotavirus vaccines manufactured by …

Author: US Centers for Disease Control and Prevention

Published: 2011

Addition of Severe Combined Immunodeficiency as a Contraindication for Administration of Rotavirus Vaccine

In response to reported cases of vaccine-acquired rotavirus infection in infants with severe combined immunodeficiency (SCID) following rotavirus vaccine administration, both Merck & Co. and GlaxoSmithKline Biologicals have revised …

Author: US Centers for Disease Control and Prevention

Published: 2010

Ask the Experts: Update on the Safety of Rotavirus Vaccines

This article, published by the American Pharmacists Association, addresses the safety of rotavirus vaccines, including the latest information on possible contamination issues. The authors indicate that the documented benefits of RotaTeq and …

Author: Mojica B, Hess K

Published: 2011

Association Between Pentavalent Rotavirus Vaccine and Severe Rotavirus Diarrhea Among Children in Nicaragua

This article, published in the Journal of the American Medical Association, summarizes the first study to assess the impact of rotavirus vaccination in a developing country. The authors concluded that the vaccine could have a substantial impact on …

Author: Patel M, Pedreira C, De Oliveira LH, et al.

Published: 2009

Broadening the Age Restriction for Initiating Rotavirus Vaccination in Regions With High Rotavirus Mortality: Benefits of Mortality Reduction Versus Risk of Fatal Intussusception

This article, published in Vaccine, reports on a study that assessed the potential benefits of mortality reduction versus the risk of fatal intussusception when (a) the first dose of rotavirus vaccine was administered by 12 weeks of age compared …

Author: Patel MM, Clark AD, Glass RI, et al.

Published: 2009

Burden and Aetiology of Diarrhoeal Disease in Infants and Young Children in Developing Countries (the Global Enteric Multicenter Study, GEMS): A Prospective, Case-Control Study

This article, published in The Lancet, reports on results of the Global Enteric Multicenter Study (GEMS), which was designed to identify the aetiology and population-based burden of pediatric diarrheal disease in sub-Saharan Africa and south Asia. …

Author: Kotloff KL, Nataro JP, Blackwelder WC, et al.

Published: 2013

Burden of Disease and Circulating Serotypes of Rotavirus Infection in Sub-Saharan Africa: Systematic Review and Meta-analysis

To assess the potential impact of rotavirus vaccines in sub-Saharan Africa, researchers reviewed recent published data on rotavirus burden among children aged five years old and circulating serotypes in sub-Saharan Africa. Though many countries …

Author: Sanchez-Padilla E, Grais RF, Guerin PJ, et al.

Published: 2009

Burden of Paediatric Rotavirus Gastroenteritis (RVGE) and Potential Benefits of a Universal Rotavirus Vaccination Programme with a Pentavalent Vaccine in Spain

This study, published in BMC Public Health, assesses the health outcomes and the economic impact of a universal rotavirus vaccination program with RotaTeq, a pentavalent rotavirus vaccine, against a no vaccination program in Spain. The study …

Author: Diez-Domingo J, Surinach NL, Alcalde NM, Betegon L, Largeron N, Trichard M

Published: 2010

Calling the Shots: A Review of Global Immunisation Initiatives and Future Priorities

This report reviews the successes and challenges of current global immunization programs, with a particular focus on: pneumonia, diarrheal disease, polio, measles, and rubella. It argues that while there is much to be applauded, there is a funding …

Author: Royal College of Paediatrics and Child Health

Published: 2013

Can Successful Vaccines Teach Us How to Induce Efficient Protective Immune Responses?

This article, published in Nature Medicine, reviews current successful vaccines and identifies their mechanisms of protection in the hopes of tackling the challenges posed by those infectious targets that have thus far escaped successful …

Author: Lambert PH, Liu M, Siegrist CA

Published: 2005

Changes in Hospitalisations for Acute Gastroenteritis in Australia After the National Rotavirus Vaccination Program

This retrospective analysis, published in the Medical Journal of Australia, found a sustained and substantial decline in rotavirus hospitalizations as well as hospitalizations for diarrhea of any cause following national vaccine …

Author: Dey A, Wang H, Menzies R, Macartney K

Published: 2012

Clinical Consequences of Rotavirus Acute Gastroenteritis in Europe, 2004-2005: The REVEAL Study

After a multicenter study in several European countries, investigators determined that acute gastroenteritis caused by rotavirus resulted in more hospitalizations and emergency department visits than acute gastroenteritis from another cause. This …

Author: Guiaquinto C, Van Damme P, Huet F, et al.

Published: 2007

Common Virus and Senseless Killer: Briefing Paper on Rotavirus

This briefing paper underscores the burden of rotavirus disease and highlights the promise of vaccines to combat the virus as the global health community prepares for worldwide introduction.

Author: PATH

Published: 2009

Community Diarrhea Incidence Before and After Rotavirus Vaccine Introduction in Nicaragua

This article, published in the American Journal of Tropical Medicine and Hygiene, reports on a study that compared the incidence of diarrhea before and after the introduction of the pentavalent rotavirus vaccine in Leon, Nicaragua. The results …

Author: Becker-Dreps S, Meléndez M, Liu L, et al.

Published: 2013

Comparative Evaluation of the Potential Impact of Rotavirus Versus HPV Vaccination in GAVI-Eligible Countries: A Preliminary Analysis Focused on the Relative Disease Burden

This article, published in BMC Infectious Diseases, reports on a study that aimed to provide early insight into how the comparative impact of different new vaccines could be assessed in resource-poor settings with respect to affordability, …

Author: Kim SY, Sweet S, Chang J, Goldie SJ

Published: 2011

Comparative Review of Three Cost-Effectiveness Models for Rotavirus Vaccines in National Immunization Programs: A Generic Approach Applied to Various Regions in the World

This article, published in BMC Medicine, critically reviews available cost-effectiveness models for rotavirus vaccination, comparing their designs using a standardized approach and studying the similarities and differences in cost-effectiveness …

Author: Postma MJ, Jit M, Rozenbaum MH, Standaert BA, Tu HA, Hutubessy RCW

Published: 2011

A Comprehensive Approach to Rotavirus Vaccines

This fact sheet highlights PATH's work to address rotavirus and includes general information about its efforts to increase access to and effectiveness of existing vaccines, as well as to develop new vaccines.

Author: PATH

Published: 2014

A Cost Effectiveness and Capacity Analysis for the Introduction of Universal Rotavirus Vaccination in Kenya: Comparison Between Rotarix and RotaTeq Vaccines

The authors of this article, published in PLoS ONE, applied cost-effectiveness modeling and a cold-chain impact assessment to aid decision-making on rotavirus vaccine introduction in Kenya. They conclude that use of either vaccine is cost-effective, …

Author: van Hoek AJ, Ngama M, Ismail A, et al.

Published: 2012

Cost Effectiveness of Rotavirus Vaccines and Other Interventions for Diarrhoeal Diseases: Meeting Report 2006

This report from the WHO's Weekly Epidemiologic Record summarizes a meeting convened by PATH, WHO, and the US Centers for Disease Control and Prevention (CDC) on the economic burden of rotavirus disease and cost-effectiveness of vaccines. The …

Author: World Health Organization

Published: 2006

Cost-Effectiveness and Potential Impact of Rotavirus Vaccination in the United States

This study, published in the journal Pediatrics, examines the costs and benefits of routine rotavirus vaccination for infants in the US, using a hypothetical cohort of unvaccinated infants. Researchers determined that, at current prices, …

Author: Widdowson MA, Meltzer MI, Zhang X, et al.

Published: 2007

Cost-Effectiveness of a New Rotavirus Vaccination Program in Pakistan: A Decision Tree Model

This article, published in Vaccine, reports on the expected public health impact of a national rotavirus vaccination program in Pakistan by performing a cost-effectiveness study from the perspective of the health care system. Across a range of …

Author: Patel HD, Roberts ET, Constenla DO

Published: 2013

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