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Total results with these characteristics: 80

Disease: Shigellosis and enterotoxigenic Escherichia coli (ETEC)

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Analysis of Strategies to Successfully Vaccinate Infants in Developing Countries Against Enterotoxigenic E. coli (ETEC) Disease

This article, published in Vaccine, outlines current candidates for a safe and effective vaccine against ETEC. The authors argue that a critical roadblock to achieving this goal has not been the science as much as the lack of a sufficiently funded …

Author: Walker RI, Steele D, Aguado T, Ad Hoc ETEC Technical Expert Committee

Publication date: 2007

An Assessment of Enterotoxigenic Escherichia coli and Shigella Vaccine Candidates for Infants and Children

This review article, published in Vaccine, describes the approaches to enterotoxigenic Escherichia coli (ETEC) and Shigella vaccines that are currently under development, including a range of both cellular and subunit approaches for each pathogen. …

Author: Walker RI

Publication date: 2015

Bacterial Diarrhea

This article, published in the New England Journal of Medicine, provides a description of bacterial diarrhea and evidence supporting various strategies to combat this problem. Also included are a list of pathogens that cause bacterial diarrhea and …

Author: DuPont HL

Publication date: 2009

Burden and Aetiology of Diarrhoeal Disease in Infants and Young Children in Developing Countries (the Global Enteric Multicenter Study, GEMS): A Prospective, Case-Control Study

This article, published in The Lancet, reports on results of the Global Enteric Multicenter Study (GEMS), which was designed to identify the aetiology and population-based burden of pediatric diarrheal disease in sub-Saharan Africa and south Asia. …

Author: Kotloff KL, Nataro JP, Blackwelder WC, et al.

Publication date: 2013

The Cascading Burden of Diarrheal Disease: Revealing the Hidden Costs of ETEC and Shigella Diarrhea

This interactive data visualization tool tells the full story behind the global burden of enterotoxigenic Escherichia coli and Shigella, the two leading bacterial causes of diarrhea. The visualization features a new set of global disease burden …

Author: PATH

Publication date: 2016

The Case for Investment in Enterotoxigenic Escherichia coli Vaccines

This market assessment aims to increase the awareness of biotechnology and pharmaceutical companies worldwide about the opportunities and potential markets that exist for low-cost and effective vaccines against enterotoxigenic Escherichia coli …

Author: PATH; BIO Ventures for Global Health

Publication date: 2011

Center for Vaccine Innovation and Access

This website provides information about the work of PATH’s Center for Vaccine Innovation and Access, which brings together expertise across every stage of vaccine research, development, and introduction to make lifesaving vaccines globally …

Author: PATH

Characterization of Mucosal Immune Responses to Enterotoxigenic Escherichia coli Vaccine Antigens in a Human Challenge Model: Response Profiles After Primary Infection and Homologous Rechallenge With Strain H10407

There is currently a poor understanding of the immune responses that correlate best with protection against enterotoxigenic Escherichia coli (ETEC) illness, which presents a challenge to vaccine development efforts. This article, published in …

Author: Chakraborty S, Harro C, DeNearing B, et al.

Publication date: 2016

Clinical Trial to Evaluate Safety and Immunogenicity of an Oral Inactivated Enterotoxigenic Escherichia coli Prototype Vaccine Containing CFA/I Overexpressing Bacteria and Recombinantly Produced LTB/CTB Hybrid Protein

This article, published in Vaccine, describes the results of a randomized, comparator controlled, double-blind Phase 1 trial in 60 Swedish adults testing a prototype of a new oral vaccine candidate against enterotoxigenic Escherichia coli (ETEC) …

Author: Lundgren A, Leach S, Tobias J, et al.

Publication date: 2013

A Combination Vaccine Consisting of Three Live Attenuated Enterotoxigenic Escherichia coli Strains Expressing a Range of Colonization Factors and LTB is Well Tolerated and Immunogenic in a Placebo-Controlled Double-Blind Phase 1 Trial in Healthy Adults

This article, published in Clinical and Vaccine Immunology, describes the results of a Phase 1 trial of a trivalent, live attenuated enterotoxigenic Escherichia coli vaccine candidate, ACE527. The study indicated that ACE527 had a strong safety …

Author: Harro C, Sack D, Bourgeois AL, et al.

Publication date: 2011

Combination Vaccines Against Diarrheal Diseases

This article, published in Human Vaccines & Immunotherapeutics, outlines the need for the development of affordable and effective combination vaccines against diarrheal diseases. Despite the well-documented global burden of diarrheal diseases, …

Author: Venkatesan MM, Van de Verg LL

Publication date: 2015

Comparison of Cost-of-Illness with Willingness-to-Pay Estimates to Avoid Shigellosis: Evidence from China

Published in Health Policy and Planning, this compares cost-of-illness (COI) with stated preference estimates of willingness-to-pay associated with shigellosis in a rural area of China to evaluate the economic benefits of disease …

Author: Guh S, Xingbao C, Poulos C, et al.

Publication date: 2008

Conservation and Immunogenicity of Novel Antigens in Diverse Isolates of Enterotoxigenic Escherichia coli

This article, published in PLoS Neglected Tropical Diseases, reports on a study that aimed to identify protective antigens shared by many enterotoxigenic Escherichia coli (ETEC) strains to help inform the development of new vaccine candidates. Using …

Author: Luo Q, Qadri F, Kansal R, Rasko DA, Sheikh A, Fleckenstein JM

Publication date: 2015

Current Progress in Developing Subunit Vaccines Against Enterotoxigenic Escherichia coli-Associated Diarrhea

This article, published in Clinical and Vaccine Immunology, reports on the development status of subunit vaccines against enterotoxigenic Escherichia coli (ETEC). Currently, there are no available vaccines against ETEC-associated diarrhea. …

Author: Zhang W, Sack DA

Publication date: 2015

DefeatDD.org

This website provides comprehensive resources on diarrheal disease treatment interventions, including low-osmolarity oral rehydration solution, zinc treatment, and rotavirus vaccines. Traditional interventions such as improved sanitation and …

Author: PATH

Defining Cases of Severe Pediatric Diarrhea for an Efficacy Trial of an Enterotoxigenic Escherichia coli (ETEC) Vaccine: Report on an International Workshop, Washington DC, March 2016

This article, published in Vaccine, reports the results of an expert workshop focused on the development of a severity scale specific to enterotoxigenic Escherichia coli (ETEC) that could be used to identify moderate-to-severe ETEC cases during a …

Author: Wierzba TF, Bourgis A, Steering Committee for Development of a Diarrhea Severity Scale

Publication date: 2017

Development and Preclinical Evaluation of Safety and Immunogenicity of an Oral ETEC Vaccine Containing Inactivated E. coli Bacteria Overexpressing Colonization Factors CFA/I, CS3, CS5 and CS6 Combined With a Hybrid LT/CT B Subunit Antigen, Administered Alone and Together With dmLT Adjuvant

This article, published in Vaccine, describes the development and preclinical testing of new oral vaccine against enterotoxigenic Escherichia coli (ETEC) administered alone and in combination with an adjuvant. The studies found that oral …

Author: Holmgren J, Bourgeois L, Carlin N, et al.

Publication date: 2013

Development of a Fast-Dissolving Tablet Formulation of a Live Attenuated Enterotoxigenic E. coli Vaccine Candidate

A fast-dissolving tablet (FDT) that could be packaged in a compact stackable blister sheet is a potentially attractive option for formulating oral vaccines, since it would minimally impact the cold chain and could potentially be administered …

Author: Lal M, Priddy S, Bourgeois L, et al.

Publication date: 2013

Development of a Low-Dose Challenge Model for Evaluation of Vaccines for Enterotoxigenic E. coli (ETEC) in Volunteers

This presentation from the Vaccines for Enteric Diseases conference provides results from a clinical trial that found the human challenge model currently being used to test vaccines against enterotoxigenic Escherichia coli (ETEC) is utilizing a …

Author: Harro C, DeNearing B, Marcum A, et al.

Publication date: 2009

Diarrheal Disease: Solutions to Defeat a Global Killer

Diarrheal Disease: Solutions to Defeat a Global Killer presents scientific evidence to support strategies to scale up use of interventions, including safe water, improved sanitation and hygiene, breastfeeding and optimal complementary feeding, …

Author: PATH

Publication date: 2009

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