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Disease: Malaria

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This web page provides information on malaria as well as links to relevant malaria resources.

Author: World Health Organization

Malaria: Progress, Perils, and Prospects for Eradication

This review, published in the Journal of Clinical Investigation, discusses the need to make new drugs, vaccines, and insecticides, as well as improved surveillance methods, research priorities for malaria control.

Author: Greenwood BM, Fidock DA, Kyle DE, et al.

Publication date: 2008

Malaria Vaccine Decision-Making Framework

As the development of malaria vaccines accelerates, work is also underway on the policy front to pave the way for decisions on possible malaria vaccine use. Early planning is crucial to the successful adoption and introduction of a vaccine. To …

Author: PATH

Publication date: 2012

Malaria Vaccine Initiative

The PATH Malaria Vaccine Initiative's (MVI) mission is to accelerate the development of malaria vaccines and ensure their availability and accessibility in the developing world. The website contains information on malaria and potential …

Author: PATH

Malaria Vaccine R&D in the Decade of Vaccines: Breakthroughs, Challenges and Opportunities

While progress has been made in reducing malaria mortality with other interventions, vaccines are still urgently needed to further reduce the incidence of clinical disease. The most clinically advanced candidate, RTS,S, is presently undergoing Phase …

Author: Birkett AJ, Moorthy VS, Loucq C, Chitnis CE, Kaslow DC

Publication date: 2013

Malaria Vaccine Technology Roadmap

The Malaria Vaccine Technology Roadmap was originally published in 2006 to establish a strategic plan for developing and distributing a safe, effective, and affordable vaccine to prevent malaria in children under five years of age in sub-Saharan …

Author: Malaria Vaccine Funders Group

Publication date: 2013

Malaria Vaccine: WHO Position Paper – January 2016

This article, published in the Weekly Epidemiological Record, summarizes essential background information on malaria and on GlaxoSmithKline's malaria vaccine candidate RTS,S (also known as Mosquirix™). It provides the World Health Organization's …

Author: World Health Organization

Publication date: 2016

Malaria Vaccines

This review, published in Frontiers in Bioscience, discusses the life cycle of malaria parasites and the different vaccine candidates aimed at preventing malaria at various stages of the parasites' life cycle. ABSTRACT ONLY. (Learn …

Author: Komisar JL

Publication date: 2007

MMV at a Glance

This document provides an overview of Medicines for Malaria Venture's activities and achievements.

Author: Medicines for Malaria Venture

Publication date: 2016

Moving the Needle

This quarterly e-newsletter provides updates from PATH’s Center for Vaccine Innovation and Access on its vaccine development efforts, as well as related supporting work, such as developing human challenge models, building capacity of …

Author: PATH

Optimization of a Membrane Feeding Assay for Plasmodium vivax Infection in Anopheles albimanus

Development of a malaria transmission blocking (TB) vaccine requires a better understanding of the mechanisms and main effectors responsible for TB responses. This article, published in PLOS Neglected Tropical Diseases, reports the results of a …

Author: Vallejo AF, Rubiano K, Amado A, Krystosik AR, Herrera S, Arévalo-Herrera M

Publication date: 2016

Optimizing Direct Membrane and Direct Skin Feeding Assays for Plasmodium falciparum Transmission-Blocking Vaccine Trials in Bancoumana, Mali

This article, published in The American Journal of Tropical Medicine and Hygiene, reports the results of a study conducted in Mali that identified and optimized parameters that contribute to successful mosquito feeding outcomes in both direct skin …

Author: Coulibaly MB, Gabriel EE, Sinaba Y, et al.

Publication date: 2017

Outpatient Upper Respiratory Tract Viral Infections in Children With Malaria Symptoms in Western Kenya

This article, which appeared in the American Journal of Tropical Medicine and Hygiene, describes a cross-sectional study conducted in Kenya’s Nyanza Province to investigate the burden of viral respiratory disease, including influenza, in …

Author: Waitumbi JN, Kuypers J, Anyona SB, et al.

Publication date: 2010

The PATH Innovation Pipeline for Malaria

Defeating malaria will require a range of innovative strategies and solutions. This report explains PATH's strategy and approach to fighting malaria. It includes several examples of PATH's work in malaria vaccines, diagnostics, drugs, and system …

Author: PATH

Publication date: 2017

The PATH Malaria Vaccine Initiative

This fact sheet provides an overview of PATH’s Malaria Vaccine Initiative (MVI), which works to accelerate malaria vaccine development and catalyze timely access in endemic countries toward a world free from malaria. Standing at the intersection …

Author: PATH

Publication date: 2017

Phase 1/2a Trial of Plasmodium vivax Malaria Vaccine Candidate VMP001/AS01B in Malaria-Naive Adults: Safety, Immunogenicity, and Efficacy

A vaccine to prevent infection and disease caused by Plasmodium vivax is needed both to reduce the morbidity caused by this parasite and as a key component in efforts to eradicate malaria worldwide. This article, published in PLoS Neglected …

Author: Bennett JW, Yadava A, Tosh D, et al.

Publication date: 2016

A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants

This article, published in the New England Journal of Medicine, reports results from a pivotal, large-scale Phase 3 trial of RTS,S/AS01 malaria vaccine. When compared to immunization with a control vaccine, infants (aged 6 to 12 weeks at first …

Author: The RTS,S Clinical Trials Partnership

Publication date: 2012

Potential Public Health Impact of RTS,S Malaria Candidate Vaccine in Sub-Saharan Africa: A Modelling Study

This article, published in Malaria Journal, reports the results of a study that modeled the potential public health impact of the RTS,S candidate malaria vaccine in 42 malaria-endemic countries in sub-Saharan Africa. The authors assumed vaccination …

Author: Sauboin CJ, Van Bellinghen L-A, Van De Velde N, Van Vlaenderen I

Publication date: 2015

Predicting RTS,S Vaccine-Mediated Protection From Transcriptomes in a Malaria-Challenge Clinical Trial

While the RTS,S malaria vaccine can protect against controlled human malaria infection (CHMI), little is known about how it induces an immune response. This article, published in Frontiers in Immunology, reports the results of a study that examined …

Author: van den Berg RA, Coccia M, Ballou WR, et al.

Publication date: 2017

Pregnancy and Infection

This article, published in the New England Journal of Medicine, reviews immunologic alterations during pregnancy. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author: Kourtis AP, Read JS, Jamieson DJ

Publication date: 2014

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