This 12-page brochure provides an overview of PATH's Malaria Vaccine Initiative, which works to accelerate the development of safe, effective, and affordable malaria vaccines for children under age five and pregnant women in sub-Saharan Africa.

This document aims to elucidate the World Health Organization (WHO) process for developing policy guidelines for a malaria vaccine. The analysis considered past WHO recommendations on new interventions and assessed potential implications …

This article, published in Trends in Parasitology, presents the current understanding of apical membrane antigen 1 (AMA1), particularly in relation to the potential of AMA1 as a malaria vaccine and the approaches being taken toward clinical …

This study, published in the New England Journal of Medicine, compares the efficacies of two treatments--oral artesunate and artesunate followed by mefloquine--for uncomplicated falciparum malaria in Pailin, western Cambodia, and Wang Pha, …

This graphic displays the malaria parasite's life cycle and highlights where three different types of vaccines could interrupt various stages of the life cycle.

This article, published in Nature Medicine, reviews current successful vaccines and identifies their mechanisms of protection in the hopes of tackling the challenges posed by those infectious targets that have thus far escaped successful …

This fact sheet provides an overview of the development and testing of malaria vaccine candidates through clinical trials, including an explanation of why trials are important and descriptions of each clinical trial phase.

This framework serves as a guide for planning for and conducting global and national decision-making on the introduction of a future malaria vaccine. The document also describes processes and activities that led to the development of …

This study, published in the New England Journal of Medicine, evaluated the efficacy of the RTS,S malaria vaccine given with a more immunogenic adjuvant system (AS01E) than one used in a previous study (AS02A). The study was conducted in …

This fact sheet describes PATH's work in malaria control and prevention, including its work under the Malaria Control and Evaluation Partnership in Africa and the PATH Malaria Vaccine Initiative.

This fact sheet describes PATH's work in vaccines and immunization.

The Global Malaria Action Plan is a framework for action that presents (i) a comprehensive overview of the global malaria landscape, (ii) an evidence-based approach to deliver effective prevention and treatment to all people at risk, and …

This editorial, published in the New England Journal of Medicine, discusses the RTS,S vaccine against malaria and the significance of this being the first malaria vaccine to reach an advanced stage of development.

This 25-minute BBC World documentary, produced by Rockhopper TV, takes viewers behind the scenes of two malaria vaccine development efforts--one at Sanaria, Inc. and the other at GlaxoSmithKline.

This landscape analysis identifies trends in the availability of vaccines and novel vaccine delivery technologies that are and will be of relevance to low- and middle-income countries from the present through 2025.

This fact sheet provides an overview of the unique approach PATH's Malaria Control and Evaluation Partnership in Africa (MACEPA) project takes to partnership. MACEPA works with African governments to support national leadership for coordinated …

This fact sheet provides a graphical display of the vaccine development pipeline.

This fact sheet describes a project of PATH's Malaria Vaccine Initiative focused on developing a vaccine that uses a promising platform to target the malaria parasite early in its lifecycle. The project aims to determine whether Liver Stage …

The Malaria Control and Evaluation Partnership in Africa (MACEPA) Learning Community contains a collection of resources related to malaria prevention and control. MACEPA is working in Africa to demonstrate that scaling up malaria prevention and …

MACEPA News is a periodic update on the activities of PATH's Malaria Control and Evaluation Partnership in Africa, which works to rapidly scale up proven malaria control interventions to achieve impact on health and economic indicators. Distributed …

This review, published in the Journal of Clinical Investigation, discusses the need to make new drugs, vaccines, and insecticides, as well as improved surveillance methods, research priorities for malaria control.

This report details the global investment in research and development (R&D) for new tools to prevent and treat malaria. The results presented in the report were gathered by the Malaria R&D Alliance through a survey of the 14 …

PATH's Malaria Vaccine Initiative's (MVI) mission is to accelerate the development of promising malaria vaccines and ensure their availability and accessibility in the developing world. The website contains information on malaria and potential …

This report provides an overview of a 2001 meeting of experts that reviewed the malaria vaccine market and identified gaps in essential economic and market information needed to inform decision-makers and ultimately drive the funding/investment …

This fact sheet provides an overview of the various organizations providing funding for malaria vaccine research and development, and also presents the case for additional funding.