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Disease: Respiratory syncytial virus (RSV)

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Acute Respiratory Infections (Update September 2009): Respiratory syncytial virus and parainfluenza viruses

This page on the World Health Organization website provides information on respiratory syncytial virus (RSV) and parainfluenza viruses, including the RSV disease burden, virology, and vaccines under development.

Author: World Health Organization

Publication date: 2009

Advances in RSV Vaccine Research and Development – A Global Agenda

This article, published in Vaccine, provides an overview of respiratory syncytial virus (RSV) disease and outlines the current efforts in vaccine development. It includes the feasibility for an RSV vaccine, constraints to vaccine development, …

Author: Higgins D, Trujillo C, Keech C

Publication date: 2016

Advancing Hope Against Newborn Respiratory Illness

This fact sheet outlines the importance of tackling respiratory syncytial virus (RSV), the top cause of newborn lower respiratory infections worldwide. It highlights the need to prepare for incoming RSV interventions, including vaccines for maternal …

Author: PATH

Publication date: 2016

Architecture of Respiratory Syncytial Virus Revealed by Electron Cryotomography

This article, published in the Proceedings of the National Academy of Sciences of the United States of America, describes research to carry out an electron cryotomographic characterization of cell culture-grown human respiratory syncytial virus to …

Author: Liljeroos L, Krzyzaniak MA, Helenius A, Butcher SJ

Publication date: 2013

Biological Challenges and Technological Opportunities for Respiratory Syncytial Virus Vaccine Development

This article, published in Immunological Reviews, provides an overview of the barriers that have challenged and delayed the development of vaccines against respiratory syncytial virus (RSV) and identifies opportunities that could help overcome these …

Author: Graham B

Publication date: 2011

The Bourgeoning Burden of Respiratory Syncytial Virus Among Children

This article, published in Infectious Disorders – Drug Targets, examines the disease burden of respiratory syncytial virus (RSV) in the United States, Canada, and Europe, but notes that the global burden of RSV is unknown as few studies are from …

Author: Hall CB

Publication date: 2012

Center for Vaccine Innovation and Access

This website provides information about the work of PATH’s Center for Vaccine Innovation and Access, which brings together expertise across every stage of vaccine research, development, and introduction to make lifesaving vaccines globally …

Author: PATH

Challenges and Opportunities for Respiratory Syncytial Virus Vaccines

This book chapter, published in Current Topics in Microbiology and Immunology, summarizes what is known about the virology, clinical manifestation, immunity, pathogenesis, and epidemiology of respiratory syncytial virus (RSV) as it relates to …

Author: Graham BS, Anderson LJ, eds.

Publication date: 2013

The Changing Landscape of Respiratory Syncytial Virus

Recognition of the high disease burden of respiratory syncytial virus (RSV) has led to increased efforts to prevent and treat RSV. This article, published in Vaccine, attempts to address questions that may emerge using current knowledge from the …

Author: Polack FP

Publication date: 2015

Clinical and Epidemiologic Features of Respiratory Syncytial Virus

This book chapter, published in Current Topics in Microbiology and Immunology, provides an overview of the symptoms and epidemiology for respiratory syncytial virus (RSV) and identifies four potential target populations for a vaccine—infants, …

Author: Hall CB, Simões EAF, Anderson LJ

Publication date: 2013

Clinical Presentation and Birth Outcomes Associated With Respiratory Syncytial Virus Infection in Pregnancy

Respiratory syncytial virus (RSV) is the most important cause of viral pneumonia in children worldwide and a maternal vaccine may protect both the mother and infant from RSV illness. This article, published in PLoS ONE, describes the epidemiology …

Author: Chu HY, Katz J, Tielsch J, et al.

Publication date: 2016

Correlates of Immunity to Respiratory Syncytial Virus (RSV) Associated-Hospitalization: Establishment of Minimum Protective Threshold Levels of Serum Neutralizing Antibodies

This article, published in Vaccine, reports on a study to determine if respiratory syncytial virus (RSV) specific, serum antibody titers correlate with protection against RSV-associated hospitalization at all ages. The authors identified a minimal …

Author: Piedra PA, Jewell AM, Cron SG, Atmar RL, Glezen WP

Publication date: 2003

Cross-Neutralization of Four Paramyxoviruses by a Human Monoclonal Antibody

This article, published in Nature, reports the results of a study describing a human monoclonal antibody that potentially cross-neutralizes human respiratory syncytial virus (RSV) along with three other viruses of different species. The results …

Author: Corti D, Bianchi S, Vanzetta F, et al.

Publication date: 2013

Disability-Adjusted Life Years (DALYs) for 291 Diseases and Injuries in 21 Regions, 1990–2010: A Systematic Analysis for the Global Burden of Disease Study 2010

This article, published in The Lancet, shares results from the Global Burden of Disease Study, calculating disease burden using disability-adjusted life years (DALYs) both worldwide and for 21 regions for 1990, 2005, and 2010 with methods to enable …

Author: Murray CJL, Vos T, Lozano R, et al.

Publication date: 2012

An Epidemiologic Study of Altered Clinical Reactivity to Respiratory Syncytial (RS) Virus Infection in Children Previously Vaccinated With an Inactivated RS Virus Vaccine

This article, published in the American Journal of Epidemiology, describes a study that evaluated altered clinical reactivity to a formalin-inactivated respiratory syncytial virus (RSV) vaccine candidate administered to healthy infants and children …

Author: Kapikian AZ, Mitchell RH, Chanock RM, Shvedoff RA, Stewart CE

Publication date: 1969

Epidemiology, Aetiology and Management of Childhood Acute Community-Acquired Pneumonia in Developing Countries--A Review

This article, published in the African Journal of Medicine and Medical Sciences, provides an overview of the causes of clinical pneumonia in developing countries, available vaccines for fighting pneumonia, and efforts underway and planned to expand …

Author: Falade AG, Ayede AI

Publication date: 2011

Evaluating Vaccination Strategies for Reducing Infant Respiratory Syncytial Virus Infection in Low-Income Settings

Infants account for the majority of severe respiratory syncytial virus (RSV) burden, but they are a problematic RSV vaccine target population due to their immunological immaturity. This article, published in BMC Medicine, reports on a study that …

Author: Poletti P, Merler S, Ajelli M, et al.

Publication date: 2015

Field Evaluation of a Respiratory Syncytial Virus Vaccine and a Trivalent Parainfluenza Virus Vaccine in a Pediatric Population

This article, published the American Journal of Epidemiology, describes a field study conducted in California, United States, that evaluated two formalin inactivated respiratory virus vaccines, a respiratory syncytial virus (RSV) vaccine and a …

Author: Chin J, Magoffin RL, Shearer LA, Schieble JH, Lennette EH

Publication date: 1969

Global and Regional Mortality From 235 Causes of Death for 20 Age Groups in 1990 and 2010: A Systematic Analysis for the Global Burden of Disease Study 2010

This article, published in The Lancet, reports on the results of the Global Burden of Diseases, Injuries, and Risk Factors Study 2010, which aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes. The …

Author: Lozano R, Naghavi M, Foreman K, et al.

Publication date: 2012

Global Burden of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Young Children: A Systematic Review and Meta-analysis

This article, published in The Lancet, describes research to estimate the global incidence of and mortality from episodes of acute lower respiratory infection (ALRI) due to respiratory syncytial virus (RSV) in children younger than five years …

Author: Nair H, Nokes DJ, Gessner BD, et al.

Publication date: 2010

Global Burden of Disease

The Global Burden of Disease Study is the most comprehensive global observational epidemiological study to date. It describes mortality and morbidity from major diseases, injuries, and risk factors to health at the global, national, and regional …

Author: Global Burden of Disease Study Collaborators

Immunopathology of RSV Infection: Prospects for Developing Vaccines Without This Complication

This article, published in Reviews in Medical Virology, outlines the different challenges to developing a vaccine against respiratory syncytial virus (RSV). The authors note that maternal vaccination may be an optimal strategy to protect very young …

Author: van Drunen Littel-van den Hurk S, Mapletoft JW, Arsic N, Kovacs-Nolan J

Publication date: 2007

Impact of Placental Malaria and Hypergammaglobulinemia on Transplacental Transfer of Respiratory Syncytial Virus Antibody in Papua New Guinea

As maternal immunization becomes an increasingly important strategy for protection of very young infants, identification of factors that could impact vaccine effectiveness by modifying the efficiency of transplacental antibody transport will be …

Author: Atwell JE, Thumar B, Robinson LJ, et al.

Publication date: 2016

Increasing Access to Lifesaving Vaccines: PATH Closes the Immunization Gap Through Innovation and Collaboration

This fact sheet outlines PATH's work on vaccines and immunization. Topic areas include developing affordable vaccines, designing innovative vaccine technologies, and expanding uptake of existing vaccines. These efforts reduce the burden of malaria, …

Author: PATH

Publication date: 2013

Jordan Report: Accelerated Development of Vaccines 2012

This comprehensive report includes expert articles on a variety of vaccine-related topics and updates on vaccine research for specific infectious diseases, such as influenza, malaria, respiratory syncytial virus, and rotavirus.

Author: US National Institute of Allergy and Infectious Diseases

Publication date: 2012

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