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Total results with these characteristics: 275

Disease: Rotavirus

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Efficacy of a Monovalent Human-Bovine (116E) Rotavirus Vaccine in Indian Infants: A Randomised, Double-Blind, Placebo-Controlled Trial

This article, published in The Lancet, reports on the results of a Phase 3 study to assess the efficacy and tolerability of a monovalent human-bovine rotavirus vaccine (116E) for severe rotavirus gastroenteritis in low-resource urban and rural …

Author: Bhandari N, Rongsen-Chandola T, Bavdekar A, et al.

Publication date: 2014

Efficacy of Human Rotavirus Vaccine Against Rotavirus Gastroenteritis During the First 2 Years of Life in European Infants: Randomised, Double-Blind Controlled Study

This article, published in The Lancet, presents data that show high efficacy for GSK's Rotarix® administered with routine vaccines. Over two seasons, Rotarix® demonstrated 90 percent efficacy against severe rotavirus among European …

Author: Vesikari T, Karvonen A, Prymula R, et al.

Publication date: 2007

Efficacy of Pentavalent Rotavirus Vaccine Against Severe Rotavirus Gastroenteritis in Infants in Developing Countries in Asia: A Randomised, Double-Blind, Placebo-Controlled Trial

This article, published in The Lancet, assesses the clinical efficacy of the pentavalent, live oral rotavirus vaccine for the prevention of severe rotavirus gastroenteritis in infants in Bangladesh and Vietnam. Study results demonstrated vaccine …

Author: Zaman K, Dang DA, Victor JC, et al.

Publication date: 2010

Efficacy of Pentavalent Rotavirus Vaccine Against Severe Rotavirus Gastroenteritis in Infants in Developing Countries in Sub-Saharan Africa: A Randomised, Double-Blind, Placebo-Controlled Trial

This article, published in The Lancet, shares results of an efficacy study of the pentavalent, live oral rotavirus vaccine in Ghana, Kenya, and Mali. Results showed 39.3 percent efficacy against  severe rotavirus gastroenteritis. The authors …

Author: Armah GE, Sow SO, Breiman RF, et al.

Publication date: 2010

Efficacy of the Human Rotavirus Vaccine RIX4414 in Malnourished Children

This study, published in the Journal of Infectious Diseases, determined that the Rotarix® vaccine produced by GlaxoSmithKline decreased the incidence severe gastroenteritis caused by rotavirus at comparable rates among well-nourished and …

Author: Perez-Schael I, Salinas B, Tomat M, et al.

Publication date: 2007

Ending Preventable Child Deaths From Pneumonia and Diarrhoea by 2025 – The Integrated Global Action Plan for Pneumonia and Diarrhoea (GAPPD)

This report proposes a cohesive approach to ending preventable pneumonia and diarrhea deaths in children. It outlines a protect, prevent, and treat framework that integrates proven effective interventions for pneumonia and diarrhea, including the …

Author: World Health Organization, United Nations Children's Fund

Publication date: 2013

Estimating Global, Regional and National Rotavirus Deaths in Children Aged <5 Years: Current Approaches, New Analyses and Proposed Improvements

This article, published in PLoS ONE, reports figures for global, regional, and national rotavirus-related deaths in children under five years of age, and discusses updated methodologies for data analysis. In order to reduce delays in …

Author: Clark A, Black R, Tate J, et al.

Publication date: 2017

Evaluaciónde Costo-Efectividad de la Vacuna Anti-rotavirus en Chile

This article, published in Revista Médica de Chile, outlines an economic model that determined rotavirus vaccination is a cost-effective intervention that can effectively reduce the disease burden and healthcare costs of rotavirus …

Author: Constenla D, O'Ryan M, Navarrete M, Antil L, Rheingans R

Publication date: 2006

Evaluating the Potential Risks and Benefits of Infant Rotavirus Vaccination in England

This article, published in Vaccine, reports on a risk-benefit analysis of rotavirus vaccination that compared potential vaccine-related risks with estimated vaccine benefits in the 2012 birth cohort in England. The authors estimate that rotavirus …

Author: Clark A, Jit M, Andrews N, Atchison C, Edmunds WJ, Sanderson C

Publication date: 2014

Evaluation of Cost-Effectiveness of Live Oral Pentavalent Reassortant Rotavirus Vaccine Introduction in Ghana

This article, published in Vaccine, estimates the cost-effectiveness of introducing the rotavirus vaccine RotaTeq® in Ghana. The authors estimated the average costs of treating children with diarrhea in the Ashanti region of Ghana as inpatients …

Author: Abbott C, Tiede B, Armah G, Mahmoud A

Publication date: 2012

Evaluation of Vaccines Against Enteric Infections: A Clinical and Public Health Research Agenda for Developing Countries

This article, from the Philosophical Transactions of the Royal Society B, provides a review of the enteric vaccines currently available and their lack of use in developing countries. The author purports that the reasons for this are multiple and …

Author: Clemens J

Publication date: 2011

Expanding the Evidence Base to Inform Vaccine Introduction: Program Costing and Cost-Effectiveness Analyses

This supplement to Vaccine contains 38 articles featuring country-led research to support real-time policymaking, including cost-effectiveness, program costing, and analyses of financial flows for vaccine introduction. It highlights work undertaken …

Author: Andrus JK, Walker DG, eds.

Publication date: 2015

From Introduction to Impact: The Story of Rotavirus Vaccines

This video follows three countries—Nicaragua, Ghana, and Malawi—that helped pave the way for rotavirus vaccine introductions in low-income countries worldwide. Rotavirus vaccines are saving lives and improving health in countries where they …

Author: PATH

Publication date: 2017

Fulfilling the Promise of Rotavirus Vaccines: How Far Have We Come Since Licensure?

This review, published in The Lancet Infectious Diseases, summarizes the role of rotavirus vaccination in reducing childhood hospitalizations and deaths due to severe diarrhea. The authors also highlight insights revealed through routine …

Author: Patel MM, Glass R, Desai R, Tate JE, Parashar UD

Publication date: 2012

Gastroenteritis Hospitalizations in Older Children and Adults in the United States Before and After Implementation of Infant Rotavirus Vaccination

This article, published in the Journal of the American Medical Association, reports on a study that explored the indirect impact of rotavirus vaccines on older age groups. The authors assessed patterns of gastroenteritis hospitalizations among …

Author: Gastañaduy PA, Curns AT, Parashar UD, Lopman BA

Publication date: 2013

The Gavi Full Country Evaluations

The Gavi Full Country Evaluations (FCE) are prospective studies that aim to understand and quantify the barriers and drivers of immunization program improvement, with an emphasis on the contribution of Gavi, the Vaccine Alliance in four countries: …

Author: PATH

Generic Protocol for Monitoring Impact of Rotavirus Vaccination on Gastroenteritis Disease Burden and Viral Strains

This document outlines a uniform approach to monitoring the impact of rotavirus vaccines in national programs, including guidelines for monitoring disease trends and evaluating vaccine effectiveness and changes in strain patterns among …

Author: World Health Organization

Publication date: 2008

Generic Protocols for (i) Hospital-Based Surveillance to Estimate the Burden of Rotavirus Gastroenteritis in Children and (ii) a Community-Based Survey on Utilization of Health Care Services for Gastroenteritis in Children

This guide is intended for use in epidemiological surveillance activities aimed at collecting data on rotavirus disease burden.

Author: World Health Organization

Publication date: 2002

Global Burden of Childhood Pneumonia and Diarrhoea

This article, published in The Lancet, reviews the epidemiology of childhood diarrhea and pneumonia in 2010 to 2011 to inform the planning of integrated control programmes for both illnesses. The estimates show 1.731 billion episodes of diarrhea and …

Author: Walker CL, Rudan I, Liu L, et al.

Publication date: 2013

Global Burden of Disease

The Global Burden of Disease Study is the most comprehensive global observational epidemiological study to date. It describes mortality and morbidity from major diseases, injuries, and risk factors to health at the global, national, and regional …

Author: Global Burden of Disease Study Collaborators

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