This fact sheet highlights PATH's work to develop new vaccines against rotavirus, the leading cause of diarrheal disease.

Investigators collected stool specimens from Ghanian children with acute gastroenteritis and determined that rotavirus was the most predominant cause in urban northern Ghana. This article was published in BMC Infectious Diseases.

This report estimates the global incidence of acute intussusception, outlines clinical presentation, and offers guidelines for clinical management.

The Advanced Immunization Management e-Learning tool is designed to provide comprehensive information to support immunization program managers at all stages of country-level decision-making. This module on rotavirus provides training on topics …

Developed by PATH and Stanford University, the Advanced Immunization Management (AIM) e-Learning tool is designed to provide comprehensive information to support immunization program managers at all stages of country-level decision-making. The …

This document, from the African Rotavirus Surveillance Network, provides an update on data generated from rotavirus surveillance at participating sites in the Gambia, Ghana, Kenya, Senegal, Uganda, Zambia, and Zimbabwe.

This study, published in the journal Pediatrics, reviews cases presented to the Vaccine Adverse Event Reporting System in order to determine whether severe adverse events other than intussusception occurred after vaccination with an …

This editorial, published in the Pan American Journal of Public Health, supports accelerated vaccine introduction and provides information on health inequities, program sustainability, and vaccine affordability.

This article, published in the Journal of the American Medical Association, summarizes the first study to assess the impact of rotavirus vaccination in a developing country. The authors concluded that the vaccine could have a substantial impact on …

To assess the potential impact of rotavirus vaccines in sub-Saharan Africa, researchers reviewed recent published data on rotavirus burden among children aged five years old and circulating serotypes in sub-Saharan Africa. Though many countries …

Investigators analyzed several epidemiological studies to determine rotavirus positivity rates and genotypes of infecting rotavirus strains from various settings in India. This article was published in the Indian Journal of Medical Research.

This article, published in Nature Medicine, reviews current successful vaccines and identifies their mechanisms of protection in the hopes of tackling the challenges posed by those infectious targets that have thus far escaped successful …

This study, published in the Pan American Journal of Public Health, conducted in four Venezuelan cities evaluated the clinical and demographic factors associated with diarrhea in hospitalized children and determined that age is a significant …

After a multicenter study in several European countries, investigators determined that acute gastroenteritis caused by rotavirus resulted in more hospitalizations and emergency department visits than acute gastroenteritis from another cause. This …

This briefing paper underscores the burden of rotavirus disease and highlights the promise of vaccines to combat the virus as the global health community prepares for worldwide introduction.

This report from the WHO's Weekly Epidemiologic Record summarizes a meeting convened by PATH, WHO, and the US Centers for Disease Control and Prevention (CDC) on the economic burden of rotavirus disease and cost-effectiveness of vaccines. The …

This review, published in the Journal of the American Medical Association, analyzed the cost-effectiveness of rotavirus vaccine introduction from the perspective of health care systems and society.

This study, published in the journal Pediatrics, examines the costs and benefits of routine rotavirus vaccination for infants in the US, using a hypothetical cohort of unvaccinated infants. Researchers determined that, at current prices, …

This paper, published in the journal Vaccine, investigates whether routine infant immunization with either currently licensed rotavirus vaccine could be cost-effective in Taiwan. The authors modeled specific disease outcomes …

This study, published in BMC Infectious Diseases, developed a model to compare the cost and disease burden of rotavirus in unvaccinated children in Mexico. The study determined that it would be highly cost-effective to include rotavirus vaccine …

This article, published in Expert Review Pharmacoeconomics Outcomes Research, reviews economic evaluations of Rotarix® and RotaTeq® and offers suggestions for future analyses of cost-effectiveness. ABSTRACT ONLY. (Learn how users in …

Investigators found that rotavirus gastroenteritis incurs considerable use of health care resources and results in substantial costs for families of patients and employers. Routine rotavirus vaccination could significantly reduce the related …

Researchers reviewed surveillance data collected over several years at sites in Bangladesh, determining that rotavirus was responsible for more than 30 percent of diarrheal disease infections. The review also revealed that the proportion of …

In June 2008, the US Centers for Disease Control (CDC) reported that the 2007 to 2008 rotavirus season in the US recorded a lower incidence and a delay in onset as compared to the previous 15 seasons. While more epidemiologic studies are …

This guide is a compilation of publicly available information about the manufacturing process of rotavirus vaccines, and aims to provide a resource for manufacturers interested in developing and registering an attenuated, oral rotavirus vaccine. …