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Disease: Shigellosis and enterotoxigenic Escherichia coli (ETEC)

Total results with these characteristics: 72

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Analysis of Data Gaps Pertaining to Enterotoxigenic Escherichia coli Infections in Low and Medium Human Development Index Countries, 1984-2005

Published in Epidemiology and Infection, this article examines both population- and facility-based studies of ETEC infections and identifies a need for additional large, population-based studies combined with facility-based studies …

Author: Gupta SK, Keck J, Ram PK, et al.

Published: 2008

Analysis of Data Gaps Pertaining to Shigella Infections in Low and Medium Human Development Index Countries, 1984-2005

Published in Epidemiology and Infection, this article seeks to identify contemporary gaps in the understanding of the global epidemiology of shigellosis, through a review of the English-language scientific literature from 1984 to 2005, …

Author: Ram PK, Crump JA, Gupta SK, Miller MA, Mintz ED

Published: 2008

Analysis of Strategies to Successfully Vaccinate Infants in Developing Countries Against Enterotoxigenic E. coli (ETEC) Disease

This article, published in Vaccine, outlines current candidates for a safe and effective vaccine against ETEC. The authors argue that a critical roadblock to achieving this goal has not been the science as much as the lack of a sufficiently funded …

Author: Walker RI, Steele D, Aguado T, Ad Hoc ETEC Technical Expert Committee

Published: 2007

Bacterial Diarrhea

This article, published in the New England Journal of Medicine, provides a description of bacterial diarrhea and evidence supporting various strategies to combat this problem. Also included are a list of pathogens that cause bacterial diarrhea and …

Author: DuPont HL

Published: 2009

Burden and Aetiology of Diarrhoeal Disease in Infants and Young Children in Developing Countries (the Global Enteric Multicenter Study, GEMS): A Prospective, Case-Control Study

This article, published in The Lancet, reports on results of the Global Enteric Multicenter Study (GEMS), which was designed to identify the aetiology and population-based burden of pediatric diarrheal disease in sub-Saharan Africa and south Asia. …

Author: Kotloff KL, Nataro JP, Blackwelder WC, et al.

Published: 2013

The Case for Investment in Enterotoxigenic Escherichia coli Vaccines

This market assessment aims to increase the awareness of biotechnology and pharmaceutical companies worldwide about the opportunities and potential markets that exist for low-cost and effective vaccines against enterotoxigenic Escherichia coli …

Author: PATH; BIO Ventures for Global Health

Published: 2011

Cholera Outbreak Training and Shigellosis (COTS) Program

COTS is an e-book, funded by the US Agency for International Development, designed to export the clinical, scientific, and public health expertise on cholera and shigellosis from the International Centre for Diarrhoeal Disease Research, …

Author: COTS Program

Clinical Trial to Evaluate Safety and Immunogenicity of an Oral Inactivated Enterotoxigenic Escherichia coli Prototype Vaccine Containing CFA/I Overexpressing Bacteria and Recombinantly Produced LTB/CTB Hybrid Protein

This article, published in Vaccine, describes the results of a randomized, comparator controlled, double-blind Phase 1 trial in 60 Swedish adults testing a prototype of a new oral vaccine candidate against enterotoxigenic Escherichia coli (ETEC) …

Author: Lundgren A, Leach S, Tobias J, et al.

Published: 2013

A Combination Vaccine Consisting of Three Live Attenuated Enterotoxigenic Escherichia coli Strains Expressing a Range of Colonization Factors and LTB is Well Tolerated and Immunogenic in a Placebo-Controlled Double-Blind Phase 1 Trial in Healthy Adults

This article, published in Clinical and Vaccine Immunology, describes the results of a Phase 1 trial of a trivalent, live attenuated enterotoxigenic Escherichia coli vaccine candidate, ACE527. The study indicated that ACE527 had a strong safety …

Author: Harro C, Sack D, Bourgeois AL, et al.

Published: 2011

Comparison of Cost-of-Illness with Willingness-to-Pay Estimates to Avoid Shigellosis: Evidence from China

Published in Health Policy and Planning, this compares cost-of-illness (COI) with stated preference estimates of willingness-to-pay associated with shigellosis in a rural area of China to evaluate the economic benefits of disease …

Author: Guh S, Xingbao C, Poulos C, et al.

Published: 2008

A Cost Function Analysis of Shigellosis in Thailand

This article, published in Value in Health, discusses a study to develop a cost function model to estimate the public treatment cost of shigellosis patients in Thailand. The study was an incidence-based cost-of-illness …

Author: Riewpaiboon A, Youngkong S, Sreshthaputra N, et al.

Published: 2008

DefeatDD.org

This website provides comprehensive resources on diarrheal disease treatment interventions, including low-osmolarity oral rehydration solution, zinc treatment, and rotavirus vaccines. Traditional interventions such as improved sanitation and …

Author: PATH

Development and Preclinical Evaluation of Safety and Immunogenicity of an Oral ETEC Vaccine Containing Inactivated E. coli Bacteria Overexpressing Colonization Factors CFA/I, CS3, CS5 and CS6 Combined With a Hybrid LT/CT B Subunit Antigen, Administered Alone and Together With dmLT Adjuvant

This article, published in Vaccine, describes the development and preclinical testing of new oral vaccine against enterotoxigenic Escherichia coli (ETEC) administered alone and in combination with an adjuvant. The studies found that oral …

Author: Holmgren J, Bourgeois L, Carlin N, et al.

Published: 2013

Development of a Fast-Dissolving Tablet Formulation of a Live Attenuated Enterotoxigenic E. coli Vaccine Candidate

A fast-dissolving tablet (FDT) that could be packaged in a compact stackable blister sheet is a potentially attractive option for formulating oral vaccines, since it would minimally impact the cold chain and could potentially be administered …

Author: Lal M, Priddy S, Bourgeois L, et al.

Published: 2013

Development of a Low-Dose Challenge Model for Evaluation of Vaccines for Enterotoxigenic E. coli (ETEC) in Volunteers

This presentation from the Vaccines for Enteric Diseases conference provides results from a clinical trial that found the human challenge model currently being used to test vaccines against enterotoxigenic Escherichia coli (ETEC) is utilizing a …

Author: Harro C, DeNearing B, Marcum A, et al.

Published: 2009

Diarrheal Disease: Solutions to Defeat a Global Killer

Diarrheal Disease: Solutions to Defeat a Global Killer presents scientific evidence to support strategies to scale up use of interventions, including safe water, improved sanitation and hygiene, breastfeeding and optimal complementary feeding, …

Author: PATH

Published: 2009

Diarrhoea: Why Children Are Still Dying and What Can Be Done

This joint report from the World Health Organization and the United Nations Children's Fund (UNICEF) focuses attention on the prevention and management of diarrheal diseases. It examines the latest available information on the burden of childhood …

Author: World Health Organization, United Nations Children's Fund

Published: 2009

Disease Burden Due to Enterotoxigenic Escherichia coli (ETEC) in the First Two Years of Life in an Urban Community in Bangladesh

Published in Infection and Immunity, a cohort of 321 children were followed from birth up to two years to determine the incidence of enterotoxigenic Escherichia coli (ETEC) in Bangladesh. Children with ETEC diarrhea were underweight and stunted …

Author: Qadri F, Saha A, Ahmed T

Published: 2007

Disease Outbreak News

This web page provides frequently updated information about current disease outbreaks, as well as disease-specific archives of past alerts and links to related resources.

Author: World Health Organization

Enteric Diseases

This web page provides information in enteric diseases, including NIAID-supported research, meeting summaries, news releases, and resources for researchers.

Author: US National Institute for Allergy and Infectious Diseases (NIAID)

Enteric Infections and the Vaccines to Counter Them: Future Directions

Published in the journal Vaccine, this article discusses the importance of creating reliable, long-term demand for the next generation of enteric vaccines, including new rotavirus, Shigella, and ETEC vaccines and priorities for achieving this …

Author: Levine M

Published: 2006

Enteric Infections, Diarrhea, and Their Impact on Function and Development

Enteric infections, with or without overt diarrhea, have profound effects on intestinal absorption, nutrition, and childhood development as well as on global mortality. Oral rehydration therapy has reduced the number of deaths from dehydration …

Author: Petri Jr. WA, Miller M, Binder HJ, et al.

Published: 2008

Enterotoxigenic Escherichia coli: Advances in Technical and Laboratory Aspects of Research and Development of Vaccines

From the Weekly Epidemiological Record, this report is from an international consultative meeting on ETEC to examine the most recent epidemiological data from the field, identify gaps in the laboratory methods for strain …

Author: World Health Organization

Published: 2008

Enterotoxigenic Escherichia coli (ETEC)

This web page provides information on ETEC, its transmission, prevention of the disease, and more.

Author: US Centers for Disease Control and Prevention

Enterotoxigenic Escherichia coli in Developing Countries: Epidemiology, Microbiology, Clinical Features, Treatment, and Prevention

This article was published in Clinical Microbiology Reviews. ETEC is an underrecognized but extremely important cause of diarrhea in the developing world where there is inadequate clean water and poor sanitation. It is the most frequent bacterial …

Author: Qadri F, Svennerholm AM, Faruque AS, Sack RB

Published: 2005

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