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Disease: Pneumococcus

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The Contribution of Specific Pneumococcal Serogroups to Different Disease Manifestations: Implications for Conjugate Vaccine Formulation and Use, Part II

To assess whether certain serogroups of Streptococcus pneumoniae are preferentially associated with specific disease manifestations, we analyzed all recent pneumococcal disease studies and assessed the relative frequency of isolation of each …

Author: Hausdorff WP, Bryant J, Paradiso P, Siber G

Publication date: 2000

Coordinated Surveillance and Detection of Pneumococcal and Haemophilus influenzae type b (Hib) Disease in Developing Countries

This supplemental issue of Clinical Infectious Diseases provides numerous articles on the surveillance and detection of pneumococcal and Haemophilus influenzae type b disease in developing countries. Topics include progress and challenges in disease …

Author: Black S, Knoll MD, eds.

Publication date: 2009

A Cost Comparison of Introducing and Delivering Pneumococcal, Rotavirus and Human Papillomavirus Vaccines in Rwanda

This article, published in Vaccine, reports on a cost comparison of introducing multiple vaccines in a single country and then assessing the financial and economic impact at the time and implications for the future. The objective of the analysis was …

Author: Ngabo F, Levin A, Wang SA, et al.

Publication date: 2015

Current Concepts in Host-Microbe Interaction Leading to Pneumococcal Pneumonia

This article, published in Current Opinion in Infectious Diseases, reviews new insights into the pathogenesis of pneumococcal disease. The authors discuss new mechanisms by which microbial factors govern the ability of pneumococcus to progress from …

Author: Vernatter J, Pirofski L

Publication date: 2013

Decline in Invasive Pneumococcal Disease After the Introduction of Protein-Polysaccharide Conjugate Vaccine

Published in the New England Journal of Medicine, this study examined population-based data from the Active Bacterial Core Surveillance of the Centers for Disease Control and Prevention to evaluate changes in the burden of invasive disease, defined …

Author: Whitney C, Farley M, Hadler J, et al.

Publication date: 2003

Decline in Pneumonia Admissions After Routine Childhood Immunization with Pneumococcal Conjugate Vaccine in the USA: A Time-Series Analysis

Published in The Lancet, this article assesses the effect of routine infant immunization with seven-valent pneumococcal conjugate vaccine (PCV7) on rates of all-cause and pneumococcal pneumonia admissions. ABSTRACT ONLY. (Learn how users in …

Author: Grijalva CG, Nuorti JP, Arbogast PG, et al.

Publication date: 2007

Developing New Vaccines Against Pneumonia and Other Pneumococcal Diseases

This fact sheet, issued by PATH, outlines PATH's pneumococcal vaccine project from a technical perspective, including an overview of PATH's vaccine development portfolio, research activities, and partners to support the development of vaccines …

Author: PATH

Publication date: 2016

Development and Clinical Evaluation of Prevnar 13, a 13-Valent Pneumocococcal CRM197 Conjugate Vaccine

This article, published in the Annals of the New York Academy of Sciences, discusses the development, clinical evaluation, and postlicensure impact of the 13-valent pneumococcal CRM(197) protein conjugate vaccine, PCV13, (Prevnar 13®). ABSTRACT …

Author: Gruber WC, Scott DA, Emini EA

Publication date: 2012

Development and Implementation of a National Programme for the Management of Severe and Very Severe Pneumonia in Children in Malawi

This article, published in PLoS Medicine, provides an overview of the development and implementation of a national program for the management of severe and very severe childhood pneumonia in Malawi. Based on a successful delivery model used by the …

Author: Enarson PM, Gie R, Enarson DA, Mwansambo C

Publication date: 2009

Development of Antibodies Against the Putative Proteinase Maturation Protein A in Relation to Pneumococcal Carriage and Otitis Media

Published in FEMS Immunology and Medical Microbiology, this article examines serum anti-pneumococcal proteinase maturation protein A antibodies at 6, 12, 18 and 24 months of age, and showed that the age-related development of antipneumococcal …

Author: Bogaert D, Holmlund E, Lahdenkari M, et al.

Publication date: 2006

Development of Lactococcal GEM-Based Pneumococcal Vaccines

Published in the journal Vaccine, this article reports on the development of a novel protein-based nasal vaccine against Streptococcus pneumoniae, in which three pneumococcal proteins were displayed on the surface of a non-recombinant, killed …

Author: Audouy S, van Selm S, van Roosmalen M, et al.

Publication date: 2007

Disease Control Priorities, Third Edition: Volume 2. Reproductive, Maternal, Newborn, and Child Health

This book focuses on maternal conditions, childhood illness, and malnutrition. Specifically, the chapters address acute illness and undernutrition in children, principally under age five. Of particular interest may be chapters 9, 10, and 19, which …

Author: Black RE, Laxminarayan R, Temmerman M, Walker N, eds.

Publication date: 2016

Diseases and the Vaccines That Prevent Them: For Parents of Infants and Young Children (Birth Through Age 6)

This series of fact sheets describes symptoms of infection as well as the benefits and risk of vaccination for 14 diseases, specifically for vaccines recommended for children from birth through the age of six years. There are two versions of each …

Author: US Centers for Disease Control and Prevention

DNA Vaccines Expressing Pneumococcal Surface Protein A (PspA) Elicit Protection Levels Comparable to Recombinant Protein

This article, published in the Journal of Medical Microbiology, provide results that show that DNA vaccines expressing PspA are able to elicit protection levels comparable to recombinant protein, even though total anti-PspA IgG response is …

Author: Ferreira DM, Miyaji EN, Oliveira MLS, et al.

Publication date: 2006

The Economic Burden of Childhood Pneumococcal Diseases in The Gambia

This article, published in Cost Effectiveness and Resource Allocation, presents the results of a study that aimed to estimate, from a societal perspective, the costs incurred by health providers and families of children with pneumococcal diseases in …

Author: Usuf E, Mackenzie G, Sambou S, Atherly D, Suraratdecha C

Publication date: 2016

Effect of a Conjugate Pneumococcal Vaccine on the Occurrence of Respiratory Infections and Antibiotic Use in Day-Care Center Attendees

Published in the Pediatric Infectious Disease Journal, this article examines whether the use of a pneumococcal conjugate vaccine could reduce the occurrence of respiratory infections and the ensuing antibiotic drug use in the day care. In this …

Author: Dagan R, Sikuler-Cohen M, Zamir O, et al.

Publication date: 2001

Effect of Combined Pneumococcal Conjugate and Polysaccharide Vaccination on Recurrent Otitis Media with Effusion

Published in the journal Pediatrics, this article assess the effect of combined pneumococcal conjugate and polysaccharide vaccinations on the recurrence of otitis media through a randomised, controlled trial.

Author: van Heerbeek N, Straetemans M, Wiertsema SP

Publication date: 2006

Effect of the Introduction of Pneumococcal Conjugate Vaccination on Invasive Pneumococcal Disease in The Gambia: A Population-Based Surveillance Study

Little information is available about the effect of pneumococcal conjugate vaccines (PCVs) in low-income countries. This article, published in The Lancet Infectious Diseases, presents the results of a study that measured the effects of PCVs on …

Author: Mackenzie GA, Hill PC, Jeffries DJ, et al.

Publication date: 2016

Effect of Vaccines on Bacterial Meningitis Worldwide

This article, published in The Lancet, focuses on the three most common causes of acute bacterial meningitis: Haemophilus influenzae, Streptococcus pneumoniae, and Neisseria meningitidis. The authors compare patterns of meningitis attributable to …

Author: McIntyre PB, O'Brien KL, Greenwood B, van de Beek D

Publication date: 2012

Effectiveness of the 13-Valent Pneumococcal Conjugate Vaccine Against Invasive Pneumococcal Disease in South African Children: A Case-Control Study

This article, published in The Lancet Global Health, reports the results of a study that assessed the effectiveness of two or more doses of 13-valent pneumococcal conjugate vaccine (PCV13) against invasive pneumococcal disease in children with HIV …

Author: Cohen C, von Mollendorf C, de Gouveia L, et al.

Publication date: 2017

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