This report, published in the Weekly Epidemiological Record, provides essential background information on pneumococcal disease and gives the current World Health Organization position concerning the use of the 23-valent …

Published in the Bulletin of the World Health Organization, this article discusses the large role pneumonia plays in the deaths of children in the developing world and the need to address these deaths through the use of prevention and treatment …

Published in the journal Infection and Immunity, this article shows that C-Ps given intranasally with mucosal adjuvant increased the resistance of mice to experimental nasopharyngeal colonization by capsulated S. pneumoniae of serotype 6B.

Published in The Lancet Infectious Diseases, this article provides an overview of the diagnostic challenges of bacterial pneumonia and highlight the need for refining the current diagnostic approach to ensure adequate epidemiological surveillance of …

This article, published in The Lancet, releases new global burden of disease data for Streptococcus pneumoniae (pneumococcus), a leading cause of bacterial pneumonia, meningitis, and sepsis in children worldwide. The results also include data at the …

This article, published in the Pan American Journal of Public Health, estimates the annual burden of pneumonia, meningitis, and acute otitis media caused by pneumococcus in children less than five years of age in Latin America and the …

This report estimates the burden and costs of pneumococcal disease in Latin America and the Caribbean in order to inform national health authorities about disease burden and the economic value of implementing a pneumococcal …

This article, published in Nature Medicine, reviews current successful vaccines and identifies their mechanisms of protection in the hopes of tackling the challenges posed by those infectious targets that have thus far escaped successful …

This review, published in Expert Review of Vaccines, looks at what has been learned from developing conjugate vaccines against Haemophilus influenzae type b, Streptococcus pneumoniae, and group C Neisseria meningitidis that could be useful for the …

To assess whether certain serogroups of Streptococcus pneumoniae are preferentially associated with specific disease manifestations, we analyzed all recent pneumococcal disease studies and assessed the relative frequency of isolation of each …

This supplemental issue of Clinical Infectious Diseases provides numerous articles on the surveillance and detection of pneumococcal and Haemophilus influenzae type b disease in developing countries. Topics include progress and challenges in disease …

This article, published in Expert Reviews of Vaccines, explains the latest knowledge about the investigational 13-valent pneumococcal conjugate vaccine (PCV-13). It outlines the composition of the vaccine and the trials it has undergone to date …

Published in the New England Journal of Medicine, this study examined population-based data from the Active Bacterial Core Surveillance of the Centers for Disease Control and Prevention to evaluate changes in the burden of invasive disease, defined …

Published in The Lancet, this article assesses the effect of routine infant immunization with seven-valent pneumococcal conjugate vaccine (PCV7) on rates of all-cause and pneumococcal pneumonia admissions. ABSTRACT ONLY. (Learn how users in …

This fact sheet highlights PATH's work to develop new vaccines against pneumococcal disease, one of the leading causes of death in children under five in the developing world.

Published in FEMS Immunology and Medical Microbiology, this article examines serum anti-pneumococcal proteinase maturation protein A antibodies at 6, 12, 18 and 24 months of age, and showed that the age-related development of antipneumococcal …

Published in the journal Vaccine, this article reports on the development of a novel protein-based nasal vaccine against Streptococcus pneumoniae, in which three pneumococcal proteins were displayed on the surface of a non-recombinant, killed …

This article, published in the Journal of Medical Microbiology, provide results that show that DNA vaccines expressing PspA are able to elicit protection levels comparable to recombinant protein, even though total anti-PspA IgG response is …

Published in the Pediatric Infectious Disease Journal, this article examines whether the use of a pneumococcal conjugate vaccine could reduce the occurrence of respiratory infections and the ensuing antibiotic drug use in the day care. In this …

Published in the journal Pediatrics, this article assess the effect of combined pneumococcal conjugate and polysaccharide vaccinations on the recurrence of otitis media through a randomised, controlled trial.

Published in the Pediatric Infectious Disease Journal, this article seeks to determine the effectiveness of the Wyeth heptavalent pneumococcal conjugate vaccine against clinical and radiograph-confirmed pneumonia in children. The heptavalent CRM197 …

This study, published in the New England Journal of Medicine, enrolled 1662 infants in a randomized, double-blind efficacy trial of a heptavalent pneumococcal polysaccharide conjugate vaccine in which the carrier protein is the nontoxic …

Published in The Lancet, this study aims to assess the efficacy of a nine-valent pneumococcal conjugate vaccine in children through a randomised, placebo-controlled, double-blind trial in eastern Gambia. Children age 6–51 weeks were randomly …

Pneumococcal conjugate vaccines have shown a high degree of success in preventing pneumococcal bacteraemia in children. They also reduce the acquisition of carriage of vaccine serotypes in the nasopharynx, and reduce otitis media caused by those …

This study, published in the Pediatric Infectious Disease Journal, aims to determine the efficacy, safety, and immunogenicity of the heptavalent CRM197 pneumococcal conjugate vaccine against invasive disease caused by vaccine serotypes and …