This case study examines the use of advocacy to reduce newborn infections in Bangladesh, specifically the market advocacy efforts by PATH and the Bangladesh Pediatric Association to engage public and private stakeholders to understand the importance of 7.1 percent chlorhexidine digluconate use.

Publication date: December 2017

Region: Asia, Global

This fact sheet describes PATH’s work to increase access to oxygen therapy for the treatment of life-threatening pneumonia and hypoxemia in newborns and children. Facilitating inclusion of expanded uses of oxygen on the World Health Organization’s Essential Medicines List, as well as the inclusion of oxygen technologies and pulse oximetry in global commodity lists and treatment guidelines, are essential for reducing child mortality.

Publication date: December 2017

Region: Global

Part of series: Oxygen technologies

In low-transmission settings, submicroscopic quantities of Plasmodium falciparum are undetectable by current rapid diagnostic tests and ELISAs. Detection of this reservoir is essential, and we need a highly sensitive laboratory reference assay to confirm these infections. This study aimed to characterize the analytical and diagnostic performance of Alere’s high-sensitivity test.

Author: Das S, Jang I, Barney B, Peck R, Rek J, Arinaitwe E, Adrama H, Murphy M, Imwong M, Ling C, Proux S, Haohankhunnatham W, Seilie A, Hanron A, Daza G, Chang M, Nakamura T, Kalnoky M, LaBarre P, Murphy S, Nosten F, Greenhouse B, Domingo G

Publication date: November 2017

Region: Global

Part of series: ASTMH posters

This study assessed the technical and programmatic feasibility of a microarray patch for sustained, intradermal delivery of primaquine to treat P. vivax malaria. The team conducted an analysis to assess the potential for using microarray patches for delivery of primaquine and to inform the development of target product profile characteristics.

Author: McGray S, Unadkat D, Rein-Weston A, Jarrahian C, Donnelly RF, Zehrung D

Publication date: November 2017

Region: Global

Part of series: ASTMH posters

Efforts to reduce transmission and eliminate malaria require an understanding of biology and transmission. A model to induce gametocytes to understand their dynamics and evaluate transmission-blocking interventions is currently unavailable. Here, we explore the use of the Controlled Human Malaria Infection model to induce gametocyte carriage with antimalarial drug regimens.

Author: Reuling I, van de Schans L, Coffeng L, Lanke K, Graumans W, van Gemert G, Teelen K, Siebelink-Stoter R, van de Vegte-Bolmer M, de Mast Q, van der Ven A, Ivinson K, Hermsen C, de Vlas S, Bradley J, Collins K, Ockenhouse C, McCarthy J, Bousema T,. Sauerwein

Publication date: November 2017

Region: Global

Part of series: ASTMH posters

Environmental enteric dysfunction (EED) is associated with serious risks for children in low-resource settings. We currently need a tool to quantitate EED biomarkers to increase the efficiency of EED screening before clinical trial enrollment. This study worked to develop an assay to detect and quantify EED biomarkers in human specimens

Author: Arndt M, Cantera J, Choy R, Tyler A, Lyman C, Boyle D

Publication date: November 2017

Region: Global

Part of series: ASTMH posters

Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory infections (ALRI) in infants and children across the globe. This fact sheet summarizes the latest RSV ALRI burden estimates at global, regional, and national scales.

Publication date: November 2017

Region: Global

PATH’s Scale-Up project works to expand the use of human papillomavirus (HPV) testing for cervical cancer prevention. Based on PATH’s experience implementing the careHPV™ test in Central America, this manual, available in Spanish and English, provides guidance for organizing a quality assurance program to screening programs adopting the careHPV test.

Publication date: November 2017

Region: Latin America, Global

Asymptomatic malaria infection in endemic areas presents new challenges, as the asymptomatic individuals constituting the human parasite reservoirs contribute to transmission. To achieve elimination, asymptomatic and submicroscopic reservoirs must be identified and treated. Here we sought to develop a highly sensitive tool to detect P. falciparum and P. vivax infection.

Author: Jang I, Tyler A, Lyman C, Barney B, Rashid A, Kahn M, Rist M, Kalnoky M, Das S, Peck R, Seilie A, Hanron A, Daza G, Chang M, Murphy S, McCarthy J, Domingo J

Publication date: November 2017

Region: Global

Part of series: ASTMH posters

The primer provides the data, messages, and resources to help understand the planning, policies, and technologies involved in oxygen delivery scale-up. The materials are useful to anyone who wants to learn about scaling up access to oxygen and integrating oxygen delivery across national and subnational policies, programs, and health budgets.

Author: Delarosa J, Pantjushenko E, Keith B, Ambler G, Lawrence C, Hayes, J

Publication date: November 2017

Region: Global

Part of series: Oxygen technologies

This policy brief brings attention to current global policies that support the provision of human milk, including donor human milk from milk banks, and encourages policymakers to take actions that will increase access to donor human milk for sick and vulnerable newborns.

Publication date: November 2017

Region: Global

Currently, the only drugs that radically cure Plasmodium vivax malaria are 8-aminoquinoline–based drugs, which can cause hemolysis in G6PD-deficient patients. Therefore, determination of G6PD level is critical before treatment. This study evaluated tests for G6PD deficiency, including validating the correlation of quantitative reference assays, and establishing recombinant G6PD controls.

Author: Pal S, LaRue N, Hrutkay S, Barney B, Kahn M, Bansil P, Kalnoky M, LeaderT, Domingo G

Publication date: November 2017

Region: Global

Part of series: ASTMH posters

This slide provides a snapshot of the respiratory syncytial virus (RSV) vaccine and monoclonal antibody (mAb) technology landscape, in the effort to track the development of RSV vaccine and mAb candidates and provide a summary of the various vaccine approaches being worked on worldwide.

Publication date: November 2017

Region: Global

The goal of the Sanitation Service Delivery (SSD) project is to improve urban sanitation outcomes through developing scalable, market-based models that contribute to structural change within the region’s sanitation sector with an initial focus on cities in Benin, Côte d’Ivoire, and Ghana. The Sanitation Technology Filtering Tools help users identify appropriate sanitation technologies for their specific use case; the tools and workshop materials can be found below.

Publication date: November 2017

Region: Africa, Global

Plasmodium vivax causes over 100 million infections annually; 8-aminoquinoline drugs can clear the parasites, but may also cause hemolysis in patients with G6PD deficiency. PATH developed GeoDX, a computer program that estimates the P. vivax burden per health facility, the total quantity of G6PD tests per country, and associated costs.

Author: Kalnoky M, Luter N, Nowak S, Metzler M, Domingo G, Malaria Atlas Project at Oxford University

Publication date: November 2017

Region: Global

Part of series: ASTMH posters

Women’s ownership of their sexual and reproductive health (SRH) is a rights-based expression of self-determination. In this issue of Outlook on Reproductive Health, we address these rights and highlight recent information on technologies and practices with high potential to enable and expand SRH self-care, including self-administration of injectable contraception, pericoital or “on-demand” contraception, safe practice of medical abortion at home, self-testing for HIV, and vaginal self-sampling for cervical cancer screening. The available evidence demonstrates that health systems and practitioners can and should trust women with many aspects of their own care.

Author: Murray M, Brady M, Drake J

Publication date: November 2017

Region: Global

Part of series: Outlook

This fact sheet provides an overview of the novel oral polio vaccine (nOPV) program, a consortium of PATH and partners that are working to advance novel vaccine candidates that will enable complete eradication and minimize the risk of polio making a comeback.

Publication date: October 2017

Region: Global

This Vaccine and Pharmaceutical Technologies fact sheet describes how PATH, in collaboration with the Solar Electric Light Fund, is advancing energy harvest controls to help health facilities power small devices in areas with limited electricity. Energy harvest controls safely divert previously unused solar energy from solar direct drive refrigerators, used to keep vaccines cool, to devices such as lights and cell phones while prioritizing the safety of vaccines.

Publication date: October 2017

Region: Global

Uterine balloon tamponades (UBT) are an effective, safe, and easy to use intervention to manage severe postpartum hemorrhage, the leading cause of maternal death. PATH and Sinapi biomedical, a South African medical device manufacturer, are advancing the Ellavi UBT—a low-cost, fully assembled UBT designed specifically for use in low-resource health facilities.

Publication date: October 2017

Region: Africa, Asia, Global

PATH and Mountain Safety Research® Global Health co-developed the MSR SE200 Community Chlorine Maker (MSR SE200), a portable, affordable device that makes chlorine on demand with the push of a button for safe, drinkable water.

Publication date: October 2017

Region: Global

Part of series: Technology Updates