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Total results with these characteristics: 105

Subject: Health technologies > Diagnostic technologies

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Detection and Characterization of Acute Febrile Illness in Western Kenya

This poster presents a study to collect and characterize specimens from febrile patients who were suspected to have malaria, pedigree specimens against a panel of nucleic acid and serological markers, and draw early insights into data that would be generated by a multiplex diagnostic platform. Presented at The American Society of Tropical Medicine and Hygiene, December 7, 2008; New Orleans, LA.

Author: Gerlach JL, Waitumbi J, Koros J, et al

Publication date: December 2008

Region: Global

HIV/AIDS Technologies: A Review of Progress to Date and Current Prospects

This paper was commissioned as an introductory landscape analysis for the aids2031 Science and Technology Working Group as part of a series of working papers under the aids2031 initiative. The paper builds on other recent landscape analysis work in the fields of HIV prevention technologies, therapeutics, and diagnostics and is intended to serve as a resource on the current status of research and development for biomedical and other technological interventions to prevent, treat, and diagnose HIV/AIDS.

Author: Alcorn K

Publication date: October 2008

Region: Global

Part of series: aids2031 working papers

Directions in Global Health (Volume 5, Issue 2)

This special issue of Directions in Global Health describes PATH's work on HIV/AIDS. Featured projects focus on implementing interactive communication techniques that promote healthier behaviors, strengthening health systems to address the dual epidemics of HIV and tuberculosis, protecting youth against HIV, challenging gender norms to reduce the spread of HIV, and advancing innovative technologies for the prevention, diagnosis, and treatment of HIV/AIDS.

Publication date: August 2008

Region: Global

Part of series: Directions in Global Health

Efficacy of Standard Methods for Water Testing at a Range of Nonstandard Temperature

Fifteen strains of Escherichia coli from various geographical areas, animal, and soil sources were tested on standard and nonstandard detection assays at temperatures from 23°C to 45°C to test the viability of currently available E. coli tests in low-resource settings. Presented at the American Society for Microbiology Conference, June 1, 2008; Boston, MA.

Author: Allen E, Dillman L, Weigl B

Publication date: June 2008

Region: Global

Chemically-Heated Non-Instrumented Nucleic-Acid Amplification Assay Platform

An overview of a diagnostic platform that PATH is developing based on nucleic-acid amplification that will require no instrumentation. It has the dual purpose of providing molecular diagnostics at the point of care as well as stabilizing nucleic-acid specimens for further analysis via a centralized surveillance system. Presented at the American Association for Clinical Chemistry 40th Annual Oak Ridge Conference, April 17, 2008; San Jose, CA.

Author: Weigl B, Domingo G, Gerlach J, et al

Publication date: April 2008

Region: Global

Developing a Point-of-Care Multiplexed Diagnostic System for Low-Resource Settings in Developing Countries

A report on the selection and evaluation of target markers for a multiplex diagnostic platform under development. Based on the DxBox platform being developed as part of a public-private consortium lead by the University of Washington. Presented at the Molecular Medicine Tri-Conference, March 25, 2008; San Francisco, CA.

Author: Gerlach JL, Anyona S, Koros J, et al

Publication date: March 2008

Region: Global

Developing a Point-of-Care Multiplexed Diagnostic System for Low-Resource Settings in Developing Countries: Challenges in Understanding Market and User Requirements

A report on appropriate product specifications and the challenges of introducing a point-of-care multiplexed diagnostic platform in low-resource settings in developing countries. Based on the DxBox platform being developed as part of a public-private consortium lead by the University of Washington. Presented at: Molecular Medicine Tri-Conference, March 25, 2008; San Francisco, CA.

Author: de los Santos T, Crudder C, Metzler M, Gerlach J, Steele M, Domingo GJ

Publication date: March 2008

Region: Global

Non-Instrumented Nucleic Acid Amplification

A report on selecting and testing phase change materials for their ability to maintain a temperature range for duration sufficient to drive a PCR reaction.  Presented at: Microfluidics, BioMEMS, and Medical Microsystems VI, January 22, 2008; San Jose, CA.

Author: Tang D, LaBarre P, Weigl BH, Stayton PS

Publication date: January 2008

Region: Global

A Comparative Performance Evaluation of Flocked Swabs Versus Dacron® Swabs for Use With an Immunodiagnostic STI Assay in a Population of High Risk Women in Bolivia

This study assessed the impact of a new sampling device on the performance of a rapid immunochromatographic strip test for chlamydia under development at PATH. The results of endocervical samples collected on flocked swabs were compared to results from those collected with Dacron® swabs. Presented at: 17th Meeting of the International Society for Sexually Transmitted Diseases Research (ISSTDR), July 29, 2007; Seattle, WA

Author: Barfield C, Tinajeros F, Revollo R, et al

Publication date: July 2007

Region: Global

Evaluation of Syndromic Management for Chlamydia Trachomatis in STI Clinics in Bolivia

A comparison of the sensitivity and specificity of syndromic management for diagnosis of chlamydia to PCR-based reference methods in a large sample of women in Bolivia. Presented at: International Society for STD Research (ISSTDR), July 26, 2007; Seattle, WA.

Author: Steele M, Tinajeros F, Cohen J, et al

Publication date: July 2007

Region: Global

Microfluidics for the Developing World

A visual introduction to the potential advantages of microfluidics as a platform for diagnostic tests in low-resource settings.

Author: Barclay AR

Publication date: May 2007

Region: Global

Collection, Processing, Storage, and Transport of Dry Blood Spots for the Assessment of Vitamin A Deficiency in the Uganda Demographic and Health Survey 2006

As part of the Uganda Demographic and Health Survey 2006, this study collected results of Vitamin A deficiency tests from a representative sample of women aged 15–49 and children aged 6–59 months. Presented at: First International Micronutrient Forum, April 16, 2007; Istanbul, Turkey.

Author: Baingana R, Kasozi D, Garrett D, Fort A

Publication date: April 2007

Region: Global

Adaptation of Immunoassays for Multiplexed Diagnosis of a Diverse Panel of Pathogens Associated With Acute Febrile Illness

This poster summarizes PATH’s recent activities as part of a consortium lead by the University of Washington to develop the DxBox, a system comprising a portable instrument and low-cost disposable cards. The prototype is being developed to diagnose typhoid fever, dengue fever, rickettsial diseases, malaria, measles, and influenza. PATH’s contributions are immunoassay development, field studies, and user needs assessment. Presented at The American Society of Tropical Medicine and Hygiene (ASTMH), November 12, 2006; Atlanta, GA.

Author: Gerlach JL, Singhal MC, Watts K, et al

Publication date: November 2006

Region: Global

Detection of High-Risk HPV-E6 Oncoprotein in Low and High-Grade Cervical Intraepithelial Neoplasia (CIN): Emerging Evidence for Predictive Validity

This poster demonstrates the predictive validity of an assay developed by Arbor Vita and PATH. For this study, cervical swab specimens collected from women screened, diagnosed, and managed in rural settings in China were tested for the presence of HPV-16 DNA then examined for HPV16-E6 expression. Results confirmed E6 is a potential diagnostic marker. Presented at: 23rd Papillomavirus Conference and Clinical Workshop, September 1, 2006; Prague, Czech Republic.

Author: Schweizer J, Somoza C, Mahoney C, et al

Publication date: September 2006

Region: Global

Developing a Lateral Flow Strip Test for E6 Oncoprotein to Identify Cervical Intraepithelial Neoplasia (CIN) at Increased Risk of Progression to Cervical Cancer

This poster outlines the evaluation of two immunochromatographic strip test platforms for the best limit of detection: one uses an antibody colloidal gold conjugate which is visually interpreted yielding qualitative results, and the other uses an antibody paramagnetic particle conjugate which is read by an instrument yielding quantitative results. The resulting limits of detection of these two methods are compared to the target limit of detection for an E6 assay of ~50 pg. Presented at: 23rd Papillomavirus Conference and Clinical Workshop, September 1, 2006; Prague, Czech Republic.

Author: Peck R, Weigl BH, Schweizer J, et al

Publication date: September 2006

Region: Global

Development of a Diagnostic Assay Based on the Binding of High-Risk HPV-E6 Oncoproteins to PDZ

A prototype of a novel diagnostic assay for cervical pre-cancer and cancer has been developed in both a sandwich ELISA-based and a lateral flow–based format (“strip test”). The test specifically detects presence of high-risk HPV-E6 and therefore promises to be of higher predictive value for cervical pre-cancer and cancer than other assays detecting merely presence of HPV. Presented at: 22rd International Papillomavirus Conference and Clinical Workshop, September 1, 2006; Vancouver, Canada.

Author: Schweizer J, Somoza C, Peck R, et al

Publication date: September 2006

Region: Global

Lab-on-a-Card Assay for Enteric Pathogens

We describe the functional elements of a diagnostic instrument and disposable enteric card system under development that rapidly identifies and differentiates Shigella, E. coli, Campylobacter, and Salmonella in stool samples. These elements, currently realized as microfluidic subcircuits on individual cards, are: (1) pathogen capture and lysing, (2) nucleic acid capture, (3) on-chip rapid PCR, and (4) lateral flow detection of amplicons. Presented at the Solid State Sensor, Actuator and Microsystems Workshop, June 4, 2006; Hilton Head Island, SC.

Author: Weigl BH, Gerdes JC, Tarr P, et al

Publication date: June 2006

Region: Global

Cost Analysis of Rapid Strip Tests for the Detection of Maternal Syphilis in Mozambique and Bolivia

Summary of a study to estimate the clinical and economic impact of prenatal syphilis screening with the rapid plasma reagin test and the immunochromatographic strip test in low-resource settings. Presented at: International Conference on Global Health: Global Health Council, May 30, 2006; Washington, DC.

Author: Levin C, Steele M, Atherly D

Publication date: May 2006

Region: Global

Device for Automated Capture of E. coli O157:H7 From Feces: Feasibility for Point-of-Care Detection

This poster reports progress incorporating magnetic beads within a unique lab card that permits efficient capture and enrichment of E. coli O157:H7 from feces. Presented at the 106th General Meeting of the American Society for Microbiology, May 21, 2006; Orlando, FL.

Author: Gerdes JC, Weigl BH, Yager P

Publication date: May 2006

Region: Global

PATH Today (Spring 2006)

This edition of PATH Today features the articles "A laboratory on a card," "Using microfluidic tests to identify infection," and "Common proteins for common prevention," which highlights the work of John Boslego and his team on pneumococcus. It also includes a letter from donor Shannon Scopa about her family's ordeal with rotavirus.

Publication date: May 2006

Region: Global

Part of series: PATH Today

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