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Total results with these characteristics: 105

Subject: Health technologies > Diagnostic technologies

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PATH Today (Fall 2010)

This issue of PATH Today highlights new, innovative technologies coming from the lab and shop at PATH, a spotlight on the December launch of the meningitis vaccine in Western Africa, and a tuberculosis project in Tanzania. Also noted is the 1+1 Challenge, expanding PATH’s presence with new country offices in Africa, and the announcement of a new leader for PATH's India country program.

Publication date: October 2010

Region: Global

Part of series: PATH Today

An E6 Oncoprotien Based Diagnostic Test for Cervical Pre-Cancer and Cancer

This poster describes the AV Avantage HPV E6 Test and the results from a small clinical pilot study. The AV Avantage HPV E6 Test uses high affinity mAb for the specific capture and detection of high-risk HPV-E6 oncoproteins in a lateral flow–based format. Presented at: 26th International Papillomavirus Conference, July 3, 2010; Montreal, Canada.

Author: Berard-Bergery M, Bisht A, Ho M, et al

Publication date: July 2010

Region: Global

An Advocacy Strategy for Adoption and Dissemination of the WHO Policy on TB Infection Control in Health Care Facilities, Congregate Settings, and Households

In 2010, the World Health Organization (WHO) issued a new policy to guide activities for controlling tuberculosis (TB) infection. This report provides guidance on advocacy for political and financial support for TB infection control from donors and countries, widespread adoption of the WHO policy, and incorporation of it into national and local policies. The report also addresses advocacy for linkages with civil society organizations in the field to ensure demand for and implementation of the WHO policy to protect health workers, patients, and communities from TB transmission.

Publication date: April 2010

Region: Global

Affordable Point-of-Care Viral RNA Specimen Processing for Low-Resource Settings

PATH conducted a detailed cost analysis in Nicaragua to understand the costs of each step required to perform viral load testing, beginning at the patient’s house and continuing to when the viral load testing result is actually communicated back to the patient’s antiretroviral therapy care provider. Using this information, PATH has developed a low-cost technology to extract HIV viral RNA at the point of care and stabilize it, removing the need for cold chain preservation of the specimen. Presented at: AACC 42nd Annual Oak Ridge Conference, April 22, 2010; San Jose, CA.

Author: Stevens DS, Beddoe AG, Hubbard L, et al

Publication date: April 2010

Region: Global

Non-Instrumented Nucleic Acid Amplification (NINA): Instrument-Free Molecular Diagnostics for Low-Resource Settings

PATH has demonstrated the use of CaO for heat and a proprietary engineered phase change material (EPCM) to maintain an assay mixture within a narrow temperature range suitable for isothermal amplification. We are currently working to develop, integrate, and validate components of this NAAT kit. Presented at: AACC 42nd Annual Oak Ridge Conference, April 22, 2010; San Jose, CA.

Author: LaBarre P, Beddoe A, Gerlach J, et al

Publication date: April 2010

Region: Global

A Novel and Sensitive Rapid Diagnostic Test for Chagas Disease

The PATH-Lemos Chagas rapid test has great potential as a highly sensitive diagnostic test for Chagas disease, suitable for use at the point-of-care.  Presented at: AACC 42nd Annual Oak Ridge Conference, April 22, 2010; San Jose, CA.

Author: Barfield CA, Barney RS, Crudder CH, et al

Publication date: April 2010

Region: Global

Simple, Inexpensive Pro-Viral DNA Preparation at the Point-of-Care

The pro-viral DNA capture card maintains the fundamental value provided by dried blood spots (ease of collection and transport from remote settings) while reducing the costs and time of performing pediatric HIV testing in the laboratory. Presented at: AACC 42nd Annual Oak Ridge Conference, April 22, 2010; San Jose, CA.

Author: Stevens DS, Barfield CA, Emery S, Overbaugh J, Gerlach J

Publication date: April 2010

Region: Global

Molecular Diagnostics Component Processes

A visual chart of the components of molecular diagnostics, using non-instrument and instrumented processing and signal detection. Presented at: PATH, December 1, 2009; Seattle, WA.

Author: Weigl B, LaBarre P

Publication date: December 2009

Region: Global

Affordable Point-of-Care Specimen Processing: A Viral RNA Extraction and Stabilization Platform

A description of a viral RNA extraction and stabilization platform. Presented at: The 5th Annual World Healthcare Innovation and Technology Congress (WHIT v.5.0), November 8, 2009; Alexandria, VA.

Author: Beddoe AG, Hubbard L, Stevens D, et al

Publication date: November 2009

Region: Global

Bacterial Etiology of Enteric Infections in Children Attending at Outpatient Clinics in Northeastern Brazil

A report on work aimed to determine the main bacterial enteric pathogens causing diarrhea in children treated in emergency rooms in Fortaleza, Ceara, Brazil. Presented at: 6th World Congress of the World Society for Pediatric Infectious Diseases, November 21, 2009; Buenos Aires, Argentina.

Author: Lima I, Soares AM, Silva-Filho JQ, Weigl BH, Rey LC, Lima A

Publication date: November 2009

Region: Global

Extending the Reach of Molecular Diagnostics

A visual display charting some diagnostic technologies (e.g., PCR, ELISA, Lumora, TwistDx, and nonintstrumented nucleic acid amplification (NINA) on axes of performance and reach (the ability to function in low-resource areas).  Presented at PATH, January 10, 2010; Seattle, WA.

Author: Weigl B

Publication date: November 2009

Region: Global

Directions in Global Health (Volume 6, Issue 2)

This issue of Directions in Global Health showcases PATH’s global presence. It highlights work related to influenza in Africa, HIV and AIDS in Eastern Europe,  Japanese encephalitis in Asia, gender-based violence in Latin America and the Caribbean, and diagnostic technologies in North America. The back cover features a map and summary information on PATH’s work around the world.

Publication date: August 2009

Region: Global

Part of series: Directions in Global Health

START-UP: Innovation in Cervical Cancer Screening

This fact sheet describes how the START-UP project is working with private-sector partners to develop two new tests that detect infection with the types of human papillomavirus (HPV) that cause cervical cancer. Designed for use in low-resource settings, these screening tools are an innovative answer to the challenge of early detection of the precursors of cervical cancer.

Publication date: July 2009

Region: Global

Barriers to the Development of a Field Tool to Determine Anemia, Iron Deficiency, Inflammation, and Malaria

Target specifications for an anemia diagnostic were determined by surveying personnel in nutritional programs, and methods and analytes were derived from a literature review. Presented at: Second International Micronutrient Forum, Bejing, China.

Author: Crudder C, Metzler M, Garrett D, Boyle DS, Levin C

Publication date: May 2009

Region: Global

E6 Based Rapid Diagnostic Test for Cervical Pre-Cancer and Cancer

A pilot clinical study suggests that E6 is an appropriate biomarker for diagnosis of cervical pre-cancer and cancer in a novel oncoprotein-based rapid diagnostic assay for cervical pre-cancer and cancer. Presented at: International Papillomavirus Conference 2009, May 8, 2009; Malmo, Sweden.

Author: Schweizer J, Berard-Bergery M, Bisht A, et al

Publication date: May 2009

Region: Global

HIV Dipstick

Part of the Technology Updates series, this fact sheet describes the HIV dipstick project at PATH.

Publication date: May 2009

Region: Global

Part of series: Technology Updates

Rapid Strip Test for Malaria

Part of the Technology Updates series, this fact sheet describes PATH's work to develop a rapid, easy-to-read, low-cost test for malaria.

Publication date: May 2009

Region: Global

Part of series: Technology Updates

The Detection of HIV-1 Proviral DNA in Less Than 20 Minutes

Recombinase Polymerase Amplification (RPA) assays were designed to detect pol from HIV-1BRU proviral DNA using real-time or immunochromatographic strip detection of RPA amplicons. Presented at: AACC 41st Annual Oak Ridge Conference, April 16, 2009; Baltimore, MD.

Author: Boyle DS, Lehman DA, Overbaugh J, et al

Publication date: April 2009

Region: Global

HOT Diagnostic Technologies: Low-Cost, Point-of-Care Nucleic Acid Amplification Using Chemical Heat to Replace Traditional Heat Sources

Demonstration of the feasibility of exothermic chemical heating as a component of a new, low-cost, disposable diagnostic platform that can be used for detection of a wide variety of infectious diseases. Presented at: 6th Annual World Health Care Congress, April 12, 2009; Washington, DC.

Author: LaBarre P, Gerlach J, Wilmoth J, Beddoe A, Singleton JL, Weigl BH

Publication date: April 2009

Region: Global

LAMP Without Electric Heat: A Chemically-Heated, Non-Instrumented Nucleic-Acid Amplification Assay Platform for Point-of-Care Use

A demonstration of the feasibility of loop-mediated isothermal amplification, supported by exothermic chemical reactions as the basis of a new, low-cost, disposable diagnostic platform that can be used for detection of a wide variety of infectious diseases. Presented at: AACC 41st Annual Oak Ridge Conference, April 16, 2009; Baltimore, MD.

Author: LaBarre P, Gerlach J, Wilmoth J, Beddoe A, Singleton JL, Weigl BH

Publication date: April 2009

Region: Global

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