Subject: Vaccines and immunization
- Paving the Way for Respiratory Syncytial Virus Prevention: Vaccine Development Against a Widespread Cause of Respiratory Illness in Infants and Young Children
This fact sheet highlights PATH's work to develop a vaccine against respiratory syncytial virus (RSV) for use in a maternal immunization strategy in the developing world that can protect infants in the critical early months of life.
Publication date: September 2013
- A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants
This article, published in the New England Journal of Medicine (NEJM), reports results from a pivotal, large-scale Phase 3 trial of RTS,S/AS01 malaria vaccine. When compared to immunization with a control vaccine, infants (aged 6 to 12 weeks at first vaccination) vaccinated with RTS,S had one-third fewer episodes of both clinical and severe malaria and had similar reactions to the injection. In this trial, RTS,S demonstrated an acceptable safety and tolerability profile. The abstract of this article is available through the NEJM by clicking on "Visit web page" below, or for free access to the full lenth article please visit malariavaccine.org and click on "Read the NEJM article."
Publication date: December 2012
- Point-of-Service Data to Drive Vaccine Supply Chains
This fact sheet outlines the different approaches that project Optimize, a World Health Organization and PATH collaboration, is testing to demonstrate that a consumption‐based system that uses service-delivery-level data can have a beneficial impact on inventory management, stock levels, and vaccine wastage.
Publication date: July 2012
- Producing a Successful Malaria Vaccine: Innovation in the Lab and Beyond
Late-stage trials of an advanced malaria vaccine candidate—which, if approved, would become the world’s first malaria vaccine—are under way. This article, published in Health Affairs, recounts the pivotal roles played by collaborations of nonprofit organizations, pharmaceutical companies, private and public donors, and countries whose citizens would benefit most directly from a vaccine.
Author: Loucq C, Birkett A, Poland D, Botting C, Nunes J, Ethelston S
Publication date: June 2011
- Progress in Cervical Cancer Prevention: The CCA Report Card
This report assesses global readiness to fight cervical cancer using new approaches and new technologies, especially in regions where the disease is a common killer. It underscores the urgent need for the global community to prioritize cervical cancer prevention and control on global health and development agendas.
Publication date: April 2011
- Progress in Preventing Cervical Cancer: Updated Evidence on Vaccination and Screening (Outlook, vol. 27, no. 2)
This issue of Outlook provides an update on opportunities for preventing cervical cancer through vaccination and screening. It summarizes recent evidence on the safety and efficacy of human papillomavirus vaccines as well as successful approaches for screening and treatment in low-resource areas. Other topics include cost-effectiveness, communication and training, and implications for policy and programs.
Author: Murray M
Publication date: May 2010
Part of series: Outlook
- Protecting Aluminum-Adjuvanted Vaccines From Freeze Damage
This overview describes how PATH has developed a low-cost and straightforward technology for protecting aluminum-adjuvanted liquid vaccines from the irreversible damage that results from freezing. Many current vaccines of importance to global health contain an aluminum salt adjuvant or its equivalent (such as aluminum hydroxide, aluminum phosphate, or calcium phosphate) and would benefit from the technology.
Publication date: October 2012
- Protecting Children for a Healthy Tomorrow: Lessons Learned from the Andhra Pradesh Partnership Project on Immunization
Publication date: 2006
- Protecting Children From Diarrheal Disease: PATH Takes a Comprehensive Approach to Combating This Leading Cause of Child Deaths
This fact sheet provides an overview of PATH's work in protecting children from diarrheal disease.
Publication date: September 2012
Part of series: Areas of focus fact sheets
- Protecting Global Access to Lifesaving Vaccines: PATH’s Global Advocacy Strategy During the United Nations Environment Program Mercury Treaty Negotiations
This case study highlights PATH and our partners’ successful advocacy efforts to ensure the protection of vaccines containing thiomersal—a preservative used in multi-dose vaccines. In January 2013, government delegates finalized a global environmental treaty on mercury having agreed to exclude vaccines containing the preservative thiomersal from further regulation.
Publication date: July 2013
- Protecting India's Children From Japanese Encephalitis
This fact sheet provides information about the partnerships and commitments that helped the Government of India introduce a landmark strategy to vaccinate children at highest risk of Japanese encephalitis. Campaigns in 2006 reached more than 9 million children, and the target population in 2007 exceeds 23 million.
Author: Phillips D
Publication date: 2007
- Protecting Newborns From Hepatitis B in Vietnam: Expanding Coverage of the Hepatitis B Vaccine Birth Dose
This fact sheet describes PATH's activities to increase the coverage and timeliness of hepatitis B birth dose vaccination in Vietnam.
Publication date: February 2014
- Pull Mechanisms for Value-Added Technologies for Vaccines: An Evaluation of the Issues Influencing Vaccine Producer Willingness to Advance, Adopt, and Commercialize Value-Added Technologies for Vaccines for Low-Income and Lower-Middle-Income Country Markets
The Optimize project, a collaboration between PATH and the World Health Organization, commissioned this white paper to examine the issues influencing vaccine producer willingness to advance, adopt, and commercialize value-added technologies for vaccines for low-income and lower-middle-income country markets.
Author: Gilchrist S
Publication date: November 2009
- Realizing the Full Potential of Childhood Immunization: How Health Professionals Can Make a Difference
This eight-page paper on local advocacy was written for doctors, nurses, and health educators. It provides practical suggestions for grassroots initiatives supporting immunization and incorporates the insights of co-author Dr. Robert Aston, an immunization advocate from the U.K.
Author: Wittet S; Aston R
Publication date: 2000
Part of series: CVP Occasional Papers
- Recent Evidence on Cervical Cancer Screening in Low-Resource Settings
This Alliance for Cervical Cancer Prevention fact sheet summarizes evidence published since 2009 on cervical cancer screening approaches for low-resource settings.
Publication date: May 2011
- Reconstitution Technologies
Part of the Technology Updates series, this fact sheet describes PATH's work on technologies to make the reconstitution of critical vaccines simpler, safer, and more economical. Streamlined reconstitution processes also help reduce medical wastage.
Publication date: September 2013
Part of series: Technology Updates
- Reducing the Need for Parallel Supply Chains
Project Optimize, a collaboration between the World Health Organization and PATH, aims to provide national immunization programs with recommendations to build integrated health supply systems, including strategic linkages with the parastatal and private sector. Ultimately, integration will allow public health programs to reduce uncertainties and risks, achieve economies of scale, shorten delivery lead times, improve procurement, provide better incentives for health workers, and improve quality of service to clients.
Publication date: July 2012
- Report to Our Contributors: Driving Transformative Innovation
This report shares highlights of PATH's use of private donations in 2012. Stories describe how support from donors helped PATH protect newborns in Vietnam from hepatitis B, provide orphaned infants in South Africa with donated breast milk, and build a new program to address the rapid rise of noncommunicable diseases in the developing world.
Publication date: August 2013
Part of series: Reports to contributors
- Results From a Survey of Immunization Stakeholders in Vietnam Regarding the Presentation, Packaging, and Distribution of Human Papillomavirus Vaccines
The purpose of this project Optimize survey was to obtain input from stakeholders within the Expanded Programme on Immunization in Vietnam about issues and perceptions related to the storage, distribution, and delivery of the current and potential options for human papillomavirus vaccine presentation and packaging.
Publication date: December 2009
- A Review of the United States Centers for Disease Control and Prevention Vaccine Management Business Improvement Project
In this document, project Optimize reviews the US Centers for Disease Control and Prevention’s (CDC’s) Vaccine Management Business Improvement Project, which represents an end-to-end reengineering of the US public-sector vaccine supply chain—from vaccine budgeting through storage and distribution. The CDC’s overarching goal was to ensure that vaccine was flowing to the right places at the right time.
Author: Wasserman N
Publication date: November 2010