PATH, in close partnership with Vietnam's National Expanded Program on Immunization (NEPI), has worked to increase the quality, safety, and efficiency of immunization services through the Iris Project. This fact sheet describes the project's process of testing province-wide systems improvements, identifying best practices, and encouraging other provinces to adopt the improvements. Work included updating and improving policies, training staff, and increasing community knowledge and demand for vaccination, particularly through technical updates, training of trainers, an introduction to supportive supervision, an out-of-the-cold-chain study, and an injection safety project with needle removers.

Publication date: 2007

Region: Asia

This issue of Directions in Global Health features five PATH projects: preparing for an avian influenza outbreak in Ukraine and Georgia; improving nevirapine packaging for prevention of mother-to-child HIV transmission; preventing postpartum hemorrhage through the POPPHI initiative; increasing access to safe abortion in Nepal; and supportive supervision of immunization programs in Vietnam.

Author: PATH

Publication date: December 2006

Region: Global

Part of series: Directions in Global Health

This study by PATH's Japanese encephalitis (JE) project evaluated whether measles vaccine and the live, attenuated JE vaccine can be safely co-administered with no effect on the immunogenicity of either.

Author: Gatchalian S, Jacobson J, Kelly K, Sutee Y, Yaïch M, Yao Y, Zhang L, Zhou B

Publication date: December 2006

Region: Asia

This edition of PATH Today features the article "Focusing on pneumonia" and updates on the Cambodia milestone in immunization coverage, new IRA rollover options for donors, Global Impact, and a profile on PATH donor Brandon Schaefer.

Publication date: December 2006

Region: Global

Part of series: PATH Today

This issue of Directions in Global Health features five PATH projects: our collaboration with the World Health Organization on the Meningitis Vaccine Project; prevention of mother-to-child HIV transmission in Ukraine; a small grants program that is catalyzing behavior change in Africa; the Inter-Act project, which is training truck drivers to slow the HIV epidemic in India; and an evaluation of neonatal resuscitators.

Author: PATH

Publication date: August 2006

Region: Global

Part of series: Directions in Global Health

Scientists have been working for decades to develop a preventive malaria vaccine. While they have successfully demonstrated that such a vaccine is possible, many challenges continue to impede progress on the road to an effective malaria vaccine. As a result, the Malaria Vaccine Advisory Committee to the World Health Organization (WHO), coordinated by the WHO Initiative for Vaccine Research, called for a collective effort to explore and address the challenges. This effort resulted in the Malaria Vaccine Technology Roadmap process.

Publication date: August 2006

Region: Global

We describe the functional elements of a diagnostic instrument and disposable enteric card system under development that rapidly identifies and differentiates Shigella, E. coli, Campylobacter, and Salmonella in stool samples. These elements, currently realized as microfluidic subcircuits on individual cards, are: (1) pathogen capture and lysing, (2) nucleic acid capture, (3) on-chip rapid PCR, and (4) lateral flow detection of amplicons. Presented at the Solid State Sensor, Actuator and Microsystems Workshop, June 4, 2006; Hilton Head Island, SC.

Author: Weigl BH, Gerdes JC, Tarr P, et al

Publication date: June 2006

Region: Global

This poster reports progress incorporating magnetic beads within a unique lab card that permits efficient capture and enrichment of E. coli O157:H7 from feces. Presented at the 106th General Meeting of the American Society for Microbiology, May 21, 2006; Orlando, FL.

Author: Gerdes JC, Weigl BH, Yager P

Publication date: May 2006

Region: Global

This special issue of Directions in Global Health features PATH's work in malaria prevention and control. It describes PATH's partnerships, experience in Zambia, clinical trial activities, efforts to prepare for vaccine introduction, and advocacy efforts.

Author: PATH

Publication date: May 2006

Region: Global

Part of series: Directions in Global Health

This edition of PATH Today features the articles "A laboratory on a card," "Using microfluidic tests to identify infection," and "Common proteins for common prevention," which highlights the work of John Boslego and his team on pneumococcus. It also includes a letter from donor Shannon Scopa about her family's ordeal with rotavirus.

Publication date: May 2006

Region: Global

Part of series: PATH Today

An exploration of one technique for drying reagents onto a microfluidics card. Reagents needed for immunocapture, lysis, and PCR for pathogen capture can be stored in trehalose or trehalose dextran. Presented at the 1st Distributed Diagnosis and Home Healthcare Conference, April 2, 2006; Arlington, VA.

Author: Ramachandran S, Weigl BH, Gerdes JC, et al

Publication date: April 2006

Region: Global

Demonstration of the PATH enteric flow-through assay as a rapid and cost effective method for detecting pathogenic bacteria in stool samples in low-resource settings. Presented at the American Association for Clinical Chemistry Oak Ridge Annual Conference, April 17, 2006; San Jose, CA.

Author: Dillman L, Fichtenholtz A, Weigl B

Publication date: April 2006

Region: Global

Publication date: 2006

Region: Asia

Publication date: 2006

Region: Asia

This 72-page document offers an in-depth look at vaccines against human papillomavirus (HPV), both currently available vaccines and those in development, including therapeutic vaccines. The document includes an examination of programmatic issues relevant to developing countries.

Author: Kols A

Publication date: 2006

Region: Global

This document summarizes the results of a study of out-of-the-cold-chain approaches for improving on-time delivery of birth doses of the hepatitis B vaccine in rural areas of China.

Publication date: 2006

Region: Asia

Publication date: 2006

Region: Asia

This document summarizes the results of a study of out-of-the-cold-chain approaches for improving on-time delivery of birth doses of the hepatitis B vaccine in four districts of Vietnam.

Publication date: 2006

Region: Asia

Publication date: 2006

Region: Asia

This document describes the Streamlining Immunization Logistics project, implemented between April 2005 and March 2006 in eight districts of Central Java and Yogyakarta, Indonesia. This project has demonstrated qualitative improvements in the efficiency of sub-national logistic systems supporting the delivery of immunization services.

Author: Lloyd J

Publication date: 2006

Region: Asia