A Healthy Dose from PATH’s Drug Development program gives advocates, policymakers, government and agency leaders, and anyone interested in global health a quarterly update on our work. Each issue features reports from the field, news on the latest clinical trial milestones, and resources in nonprofit drug development.

Publication date: 2015

Region: Global

Part of series: E-newsletters

In Kenya, malaria in pregnancy continues to contribute to high maternal and newborn morbidity and mortality. By translating emerging evidence on community-based distribution of antimalarial medicine into policy action, policymakers in Kenya have the opportunity to significantly decrease malaria-related mortality and morbidity during pregnancy, safeguarding the health and lives of countless women and newborns. This brief describes recommendations and policies at the global level and in Kenya and identifies ways in which to expand access to preventive treatment for mothers.

Publication date: October 2014

Region: Africa

In sub-Saharan Africa, malaria in pregnancy continues to contribute to high maternal and newborn morbidity and mortality. In Kisumu, Kenya, PATH developed a two-phased approach to increase coverage of malaria in pregnancy prevention activities and strengthen antenatal care. This report details the activities and outcomes of the pilot project and offers recommendations for next steps. See also Community-Based Approaches to Intermittent Preventive Treatment of Malaria in Pregnancy: A Review of Recent Studies.

Publication date: September 2014

Region: Africa

In sub-Saharan Africa, malaria in pregnancy continues to contribute to high maternal and newborn morbidity and mortality. One approach to the problem is intermittent preventive treatment of malaria in pregnancy with sulfadoxine pyrimethamine, an antimalarial safe for use in pregnancy. This report reviews recent studies and articles documenting implementation of community-based approaches that increase uptake of this therapy. See also Community-Based Approach to Intermittent Treatment for Malaria in Pregnancy in Kisumu, Kenya: Exploring the Value of Utilizing Community Health Workers in Malaria in Pregnancy Prevention.

Publication date: September 2014

Region: Africa

Artemisinin-based combination therapy is considered the gold standard treatment for malaria, but global demand has often outpaced production, and pricing has been volatile. This fact sheet describes the cross-sector partnership PATH formed to develop a new way to produce high-quality, nonseasonal, and affordable artemisinin to supplement the plant-based supply.

Publication date: July 2014

Region: Global

This fact sheet provides an overview of the work of PATH's Malaria Control and Elimination Partnership in Africa (MACEPA) to develop and document approaches for reducing malaria illnesses and deaths, with the long-term goal of malaria elimination.

Publication date: April 2014

Region: Africa

Part of the Technology Updates series, this fact sheet describes PATH’s work with diagnostic developers and stakeholders from around the world to develop a rapid, point-of-care diagnostic test for glucose-6 phosphate dehydrogenase (G6PD) deficiency. A reliable test for G6PD at the point of care is essential to malaria elimination strategies.

Publication date: April 2014

Region: Global

Part of series: Technology Updates

Artemisinin-based combination therapy is considered the gold standard treatment for malaria, but global demand has often outpaced production, and pricing has been volatile. With funding from the Bill & Melinda Gates Foundation, PATH and our partners set out to develop a new pharmaceutical manufacturing process to produce commercial volumes of high-quality, nonseasonal, and affordable artemisinin to supplement the plant-based supply. This poster, presented at the Bay Area World Malaria Day Symposium on April 25, 2014, presents key facts on malaria, the market for artemisinin, partner roles, and commercial production.

Publication date: April 2014

Region: Global

This fact sheet describes the MalariaCare partnership, a five-year effort led by PATH and funded by the US Agency for International Development and the President's Malaria Initiative. The project aims to scale up high-quality diagnosis and treatment services for malaria and other life-threatening illnesses.

Publication date: January 2014

Region: Global

This report, a follow-on to the 2011 report Staying the Course? Malaria Research and Development in a Time of Economic Uncertainty, tracks malaria research and development funding from 2007 to 2011 and provides estimates on funding needs through 2022.

Publication date: December 2013

Region: Global

To support a World Health Organization (WHO) Evidence Review Group on Malaria Diagnostics in Low-Transmission Settings in December 2013, PATH was invited to provide an overview of polymerase chain reaction and isothermal molecular methods for malaria infection detection. The PowerPoint is provided here and the WHO policy recommendations from the evidence review can be found here.

Author: LaBarre P, Tietje K

Publication date: December 2013

Region: Global

This fact sheet highlights PATH's Impact Initiatives. Through these initiatives, cross-program teams identify high-priority health areas for improvement, set institutional goals, and then mobilize resources to achieve them. Each initiative focuses on carefully selected countries and innovations.

Publication date: September 2013

Region: Global

Part of series: Areas of focus fact sheets

PATH’s health solutions touched the lives of more than 118 million people around the world in 2012. Our 2012 annual report highlights our milestones in three focus areas: diarrheal disease and pneumonia; family health; and malaria. It also features innovations in technology development and country-based health programs, a financial summary, and information about our donors, leadership, and global presence.

Publication date: May 2013

Region: Global

Part of series: Annual reports

This issue of Directions in Global Health features work by OneWorld Health, PATH’s drug development program, to lead development of innovative methods to enhance the supply of artemisinin, a key ingredient in malaria treatments. It includes a commentary by Dr. Ponni Subbiah, who directs PATH’s drug development efforts. Other articles cover work to improve cervical cancer screening, protect infants from respiratory syncytial virus, increase access to family planning, and strengthen and expand use of human milk banking.

Publication date: May 2013

Region: Global

Part of series: Directions in Global Health

This issue of PATH Today describes PATH's multipronged approach to eliminating malaria in Africa and the development of semisynthetic artemisinin, a key ingredient in malaria treatment. It includes updates on PATH's work to prevent diarrhea in Cambodia and to diagnose cervical cancer. It also contains a profile of Dean Allen, CEO of McKinstry and PATH's board treasurer.

Publication date: May 2013

Region: Global

Part of series: PATH Today

This infographic gives a visual representation of the cost-effectiveness of malaria interventions in Africa, showing that the malaria map is shrinking and that investing in malaria pays off.

Publication date: 2013

Region: Africa

This infographic gives a visual representation of PATH's three-step approach to test and treat malaria infections: rapid reporting, mass test and treat, and active surveillance.

Publication date: 2013

Region: Africa

This article, published in the New England Journal of Medicine (NEJM), reports results from a pivotal, large-scale Phase 3 trial of RTS,S/AS01 malaria vaccine. When compared to immunization with a control vaccine, infants (aged 6 to 12 weeks at first vaccination) vaccinated with RTS,S had one-third fewer episodes of both clinical and severe malaria and had similar reactions to the injection. In this trial, RTS,S demonstrated an acceptable safety and tolerability profile. The abstract of this article is available through the NEJM by clicking on "Visit web page" below, or for free access to the full lenth article please visit malariavaccine.org and click on "Read the NEJM article."

Publication date: December 2012

Region: Africa

This issue of PATH Today leads with the Mama SASHA project, which is improving nutrition, agriculture, and prenatal health care in Kenya. PATH's work to increase access to breast cancer screening in rural Peru is also featured, and donors Bryan and Martha Kim share why contributing to PATH is a smart investment. News briefs include an update about family planning and new work in Myanmar.

Publication date: November 2012

Region: Global

Part of series: PATH Today

This fact sheet summarizes PATH's work to curb emerging and epidemic diseases such as HIV/AIDS, tuberculosis, and malaria. Topic areas include advancing technologies to improve prevention, diagnosis, and treatment; strengthening health systems; encouraging healthy behaviors; and mobilizing and supporting our partners.

Publication date: September 2012

Region: Global

Part of series: Areas of focus fact sheets