As malaria programs move closer to achieving elimination, more sensitive point-of-care diagnostic tests are needed to detect the final parasite reservoirs. PATH and collaborators have developed a highly sensitive diagnostic test for Plasmodium falciparum malaria to use in the surveillance and mass screen-and-treat programs critical for malaria elimination.

Publication date: April 2017

Region: Global

This fact sheet describes soil-transmitted helminthiasis (STH), a neglected tropical disease caused by parasitic intestinal worms.

Publication date: January 2017

Region: Africa, Asia, Latin America

GHTC is a group of 40 nonprofit organizations committed to increasing awareness of the urgent need for health technologies that save lives around the world. Breakthroughs highlights the news and stories that are driving the work we do to advance innovation to save lives.

Publication date: 2017

Region: North America and Europe

Part of series: Blogs

This website provides an overview of our Diagnostics Program and its featured projects. See other PATH program websites.

Publication date: 2017

Region: Global

Part of series: Program websites

This website about PATH’s Technology Solutions program provides an overview of the program and its featured projects. See other PATH program websites.

Publication date: 2017

Region: Global

Part of series: Program websites

PATH assesses diagnostic needs, landscapes potential solutions, and determines appropriate strategies to improve diagnostic testing to support schistosomiasis and soil-transmitted helminthiases control and elimination programs. Based upon literature reviews and previous input from experts, two diagnostic use cases are prioritized for further exploration.

Author: Hawkins KR, Cantera JL, Storey HL, Leader BT, de los Santos T

Publication date: December 2016

Region: Africa, Asia, Latin America

Soil-transmitted helminths (STH) are parasitic intestinal worms that are controlled with mass drug administration in at-risk populations. The work described in this poster aims to develop a rapid, field-deployable, non-instrumented, magnetic bead-based protocol to extract STH egg DNA in stool, using Ascaris suum as model species, for use as a companion tool to recombinase polymerase amplification (RPA)-based diagnostics for STH.

Publication date: November 2016

Region: Global

Part of series: ASTMH posters

This study aimed to identify infections below the level of detection of the HRP2-based RDTs used to screen a cohort of individuals followed longitudinally in a randomized control trial. A negative RDT was highly predictive of a true negative, however a positive RDT was only correct half the time. RDT-positive/PCR-negative samples were likely to have been recently treated and cleared of parasites.

Publication date: November 2016

Region: Africa

Part of series: ASTMH posters

As part of the Healthy Markets project, this technical update on HIV rapid diagnostic tests (RDTs) includes findings on why RDTs are important; how to apply new technologies in novel ways to address local needs; and it outlines regulatory review and quality assurance findings.

Author: Peck R.

Publication date: September 2016

Region: Global

Soil-transmitted helminths (STHs) remain a massive global health problem. More robust, simple, and sensitive diagnostic tools will improve the ability of control programs to determine infection and response procedures. This document illustrates PATH’s contributions toward creating a business case for financing, developing, and deploying new diagnostics for detection of STH infection.

Publication date: September 2016

Region: Global

PATH seeks to assess diagnostic needs, survey potential solutions, and determine an appropriate strategy to identify the point in the cycle of trachoma transmission, infection, and elimination that would best be targeted for a new diagnostic technology and to articulate the business case for its development.

Publication date: July 2016

Region: Global

PATH collaborates with the US Department of Defense (DoD) to advance global health innovations. This fact sheet provides examples of successes that PATH, DoD, and our partners have had in working to adapt, test, and expand access to tools and technologies that can reduce illness in the world’s most vulnerable populations.

Publication date: May 2016

Region: Africa, North America and Europe, Global

Hazard analysis critical control points (HACCP) planning is a critical step in ensuring the safety and quality of any food product, including donated and processed human milk. PATH developed this trainer’s guide and staff workbook to guide HACCP workshops in human milk banks.

Publication date: May 2016

Region: Global

PATH’s Center for Malaria Control and Elimination is building on our unparalleled portfolio of malaria tools and projects, encompassing a broad collection of competencies and expertise, to advance efforts toward elimination, and ultimately eradication, of both P. falciparum and P. vivax malaria.

Publication date: April 2016

Region: Global

In this document, PATH seeks to synthesize primary scientific literature, technology landscape analyses, and drug development principles to describe key considerations related to the diagnosis and control of schistosomiasis and outline a business case for financing, developing, and deploying new diagnostics for detection of Schistosoma infection.

Publication date: 2016

Region: Africa, Asia, Latin America

This document describes a quality assurance (QA) program for Ov16 rapid tests that can be implemented by onchocerciasis control and elimination programs to help ensure high-quality testing and to identify areas for improvement and change. Designed for policymakers and program planners wishing to implement Ov16 rapid testing, these guidelines describe some important basic principles and the main practical aspects of a QA program.

Publication date: October 2015

Region: Africa, Latin America

Neglected tropical diseases (NTDs) infect over a billion people worldwide. PATH is working to identify and develop innovative, high-impact, low-cost diagnostic tools for NTDs for use in low-resource areas. This report outlines the process of developing target product profiles for three NTDs and includes summaries of findings.

Author: Faulx D*, Storey H*, Murray M, Cantera J, Hawkins K, Leader BT, Gallo K, de los Santos T. *equal contributors

Publication date: July 2015

Region: Global

This brochure describes the onchocerciasis surveillance rapid test SD BIOLINE Onchocerciasis IgG4. The test, developed to help onchocerciasis control and elimination programs by improving surveillance, is fast, easy to use, appropriate for field use, and minimally invasive.

Publication date: July 2015

Region: Africa

PATH is a leader in the innovation, promotion, and adoption of diagnostic technologies to support malaria elimination and ultimately eradication. As a whole, malaria-related projects and programs at PATH form a core of organizational expertise and strong infrastructure to accelerate the development and adoption of new and improved malaria diagnostics.

Publication date: March 2015

Region: Global

Innovation for Global Health is the Global Health Technologies Coalition's e-newsletter focusing on the development and delivery of lifesaving health tools to people in need worldwide. The newsletter provides updates on the latest research and policy developments on innovative tools to prevent, diagnose, and treat diseases. It includes news from US agencies, Congress, the current administration, and the global health community at large.

Publication date: 2015

Region: North America and Europe

Part of series: E-newsletters