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Browse PATH publications
Subject: Health technologies > Diagnostic technologies
- Adaptation of Immunoassays for Multiplexed Diagnosis of a Diverse Panel of Pathogens Associated With Acute Febrile Illness
This poster summarizes PATH’s recent activities as part of a consortium lead by the University of Washington to develop the DxBox, a system comprising a portable instrument and low-cost disposable cards. The prototype is being developed to diagnose typhoid fever, dengue fever, rickettsial diseases, malaria, measles, and influenza. PATH’s contributions are immunoassay development, field studies, and user needs assessment. Presented at The American Society of Tropical Medicine and Hygiene (ASTMH), November 12, 2006; Atlanta, GA.
Author: Gerlach JL, Singhal MC, Watts K, et al
Publication date: November 2006
Region: Global
- Addressing the Emerging Diabetes Epidemic in Low-Resource Settings
This fact sheet provides an overview of PATH’s efforts to develop evidence-based programs focused on diabetes prevention and control. Sixty percent of all deaths worldwide each year are due to chronic disease, mostly in low- and middle-income countries, where people develop the diseases at younger ages, suffer longer, and die earlier in life.
Publication date: May 2013
Region: Global
- Advancing a New Diagnostic Test for Onchocerciasis in Africa
Part of the Technology Updates series, this fact sheet describes PATH's work to develop and make available a rapid test to detect onchocerciasis, or river blindness.
Publication date: August 2013
Region: Global
Part of series: Technology Updates
- An Advocacy Strategy for Adoption and Dissemination of the WHO Policy on TB Infection Control in Health Care Facilities, Congregate Settings, and Households
In 2010, the World Health Organization (WHO) issued a new policy to guide activities for controlling tuberculosis (TB) infection. This report provides guidance on advocacy for political and financial support for TB infection control from donors and countries, widespread adoption of the WHO policy, and incorporation of it into national and local policies. The report also addresses advocacy for linkages with civil society organizations in the field to ensure demand for and implementation of the WHO policy to protect health workers, patients, and communities from TB transmission.
Publication date: April 2010
Region: Global
- Affordable Point-of-Care Specimen Processing: A Viral RNA Extraction and Stabilization Platform
A description of a viral RNA extraction and stabilization platform. Presented at: The 5th Annual World Healthcare Innovation and Technology Congress (WHIT v.5.0), November 8, 2009; Alexandria, VA.
Author: Beddoe AG, Hubbard L, Stevens D, et al
Publication date: November 2009
Region: Global
- Affordable Point-of-Care Viral RNA Specimen Processing for Low-Resource Settings
PATH conducted a detailed cost analysis in Nicaragua to understand the costs of each step required to perform viral load testing, beginning at the patient’s house and continuing to when the viral load testing result is actually communicated back to the patient’s antiretroviral therapy care provider. Using this information, PATH has developed a low-cost technology to extract HIV viral RNA at the point of care and stabilize it, removing the need for cold chain preservation of the specimen. Presented at: AACC 42nd Annual Oak Ridge Conference, April 22, 2010; San Jose, CA.
Author: Stevens DS, Beddoe AG, Hubbard L, et al
Publication date: April 2010
Region: Global
- Anemia Detection in Health Services: Guidelines for Program Managers
Anemia detection is often used as a screening test for iron deficiency. These guidelines are intended to help program managers establish anemia detection services or enhance existing services.
Publication date: 1996
Region: Global
- Anemia Detection Methods in Low-Resource Settings: A Manual for Health Workers
Publication date: 1997
Region: Global
- Bacterial Etiology of Enteric Infections in Children Attending at Outpatient Clinics in Northeastern Brazil
A report on work aimed to determine the main bacterial enteric pathogens causing diarrhea in children treated in emergency rooms in Fortaleza, Ceara, Brazil. Presented at: 6th World Congress of the World Society for Pediatric Infectious Diseases, November 21, 2009; Buenos Aires, Argentina.
Author: Lima I, Soares AM, Silva-Filho JQ, Weigl BH, Rey LC, Lima A
Publication date: November 2009
Region: Global
- Barriers to Access and Use of Public TB Diagnostic Services in Vietnam
This report dissects research results assessing access to and use of public tuberculosis (TB) diagnostic services in nine districts of Vietnam. The report identifies barriers to accessing public-sector TB diagnostic services at the individual, provider, and health system levels.
Publication date: February 2013
Region: Asia
- Barriers to the Development of a Field Tool to Determine Anemia, Iron Deficiency, Inflammation, and Malaria
Target specifications for an anemia diagnostic were determined by surveying personnel in nutritional programs, and methods and analytes were derived from a literature review. Presented at: Second International Micronutrient Forum, Bejing, China.
Author: Crudder C, Metzler M, Garrett D, Boyle DS, Levin C
Publication date: May 2009
Region: Global
- Breakthroughs: A Blog From the GHTC
GHTC is a group of 40 nonprofit organizations committed to increasing awareness of the urgent need for health technologies that save lives around the world. Breakthroughs highlights the news and stories that are driving the work we do to advance innovation to save lives.
Publication date: 2013
Region: North America and Europe
Part of series: Blogs
- Cervical Cancer Screening and Treatment in Low-Resource Settings: Practical Experience From PATH
From 2006 to 2011, PATH conducted HPV vaccination demonstration projects in India, Peru, Uganda, and Vietnam to provide evidence for decision-making about public-sector introduction of human papillomavirus (HPV) vaccines. This report, part of the Cervical Cancer Prevention: Practical Experience Series on the RHO Cervical Cancer website, examines the second component of a successful cervical cancer prevention program—screening and treatment of adult women for precancerous lesions.
Publication date: 2013
Region: Global
- Chagas Immunochromatographic Strip Test
Part of the Technology Updates series, this fact sheet describes PATH's work to develop a rapid, easy-to-read, low-cost test for Chagas disease.
Publication date: July 2013
Region: Global
Part of series: Technology Updates
- Chemically-Heated Non-Instrumented Nucleic-Acid Amplification Assay Platform
An overview of a diagnostic platform that PATH is developing based on nucleic-acid amplification that will require no instrumentation. It has the dual purpose of providing molecular diagnostics at the point of care as well as stabilizing nucleic-acid specimens for further analysis via a centralized surveillance system. Presented at the American Association for Clinical Chemistry 40th Annual Oak Ridge Conference, April 17, 2008; San Jose, CA.
Author: Weigl B, Domingo G, Gerlach J, et al
Publication date: April 2008
Region: Global
- Collection, Processing, Storage, and Transport of Dry Blood Spots for the Assessment of Vitamin A Deficiency in the Uganda Demographic and Health Survey 2006
As part of the Uganda Demographic and Health Survey 2006, this study collected results of Vitamin A deficiency tests from a representative sample of women aged 15–49 and children aged 6–59 months. Presented at: First International Micronutrient Forum, April 16, 2007; Istanbul, Turkey.
Author: Baingana R, Kasozi D, Garrett D, Fort A
Publication date: April 2007
Region: Global
- A Comparative Performance Evaluation of Flocked Swabs Versus Dacron® Swabs for Use With an Immunodiagnostic STI Assay in a Population of High Risk Women in Bolivia
This study assessed the impact of a new sampling device on the performance of a rapid immunochromatographic strip test for chlamydia under development at PATH. The results of endocervical samples collected on flocked swabs were compared to results from those collected with Dacron® swabs. Presented at: 17th Meeting of the International Society for Sexually Transmitted Diseases Research (ISSTDR), July 29, 2007; Seattle, WA
Author: Barfield C, Tinajeros F, Revollo R, et al
Publication date: July 2007
Region: Global
- Correspondence Between RBP and Retinol From DBS Specimens Prepared From Capillary Blood: Evidence From Zimbabwe
This document provides evidence from a study in Zimbabwe that demonstrates the correspondence between serum retinol and retionol-binding protein in estimating the prevalence of and screening for vitamin A deficiency.
Publication date: 2006
Region: Africa
- Cost Analysis of Rapid Strip Tests for the Detection of Maternal Syphilis in Mozambique and Bolivia
Summary of a study to estimate the clinical and economic impact of prenatal syphilis screening with the rapid plasma reagin test and the immunochromatographic strip test in low-resource settings. Presented at: International Conference on Global Health: Global Health Council, May 30, 2006; Washington, DC.
Author: Levin C, Steele M, Atherly D
Publication date: May 2006
Region: Global
- Detection and Characterization of Acute Febrile Illness in Western Kenya
This poster presents a study to collect and characterize specimens from febrile patients who were suspected to have malaria, pedigree specimens against a panel of nucleic acid and serological markers, and draw early insights into data that would be generated by a multiplex diagnostic platform. Presented at The American Society of Tropical Medicine and Hygiene, December 7, 2008; New Orleans, LA.
Author: Gerlach JL, Waitumbi J, Koros J, et al
Publication date: December 2008
Region: Global