A pilot clinical study suggests that E6 is an appropriate biomarker for diagnosis of cervical pre-cancer and cancer in a novel oncoprotein-based rapid diagnostic assay for cervical pre-cancer and cancer. Presented at: International Papillomavirus Conference 2009, May 8, 2009; Malmo, Sweden.

Author: Schweizer J, Berard-Bergery M, Bisht A, et al

Publication date: May 2009

Region: Global

Part of the Technology Updates series, this fact sheet describes the HIV dipstick project at PATH.

Publication date: May 2009

Region: Global

Part of series: Technology Updates

Part of the Technology Updates series, this fact sheet describes PATH's work to develop a rapid, easy-to-read, low-cost test for malaria.

Publication date: May 2009

Region: Global

Part of series: Technology Updates

Recombinase Polymerase Amplification (RPA) assays were designed to detect pol from HIV-1BRU proviral DNA using real-time or immunochromatographic strip detection of RPA amplicons. Presented at: AACC 41st Annual Oak Ridge Conference, April 16, 2009; Baltimore, MD.

Author: Boyle DS, Lehman DA, Overbaugh J, et al

Publication date: April 2009

Region: Global

Demonstration of the feasibility of exothermic chemical heating as a component of a new, low-cost, disposable diagnostic platform that can be used for detection of a wide variety of infectious diseases. Presented at: 6th Annual World Health Care Congress, April 12, 2009; Washington, DC.

Author: LaBarre P, Gerlach J, Wilmoth J, Beddoe A, Singleton JL, Weigl BH

Publication date: April 2009

Region: Global

A demonstration of the feasibility of loop-mediated isothermal amplification, supported by exothermic chemical reactions as the basis of a new, low-cost, disposable diagnostic platform that can be used for detection of a wide variety of infectious diseases. Presented at: AACC 41st Annual Oak Ridge Conference, April 16, 2009; Baltimore, MD.

Author: LaBarre P, Gerlach J, Wilmoth J, Beddoe A, Singleton JL, Weigl BH

Publication date: April 2009

Region: Global

This poster presents a study to collect and characterize specimens from febrile patients who were suspected to have malaria, pedigree specimens against a panel of nucleic acid and serological markers, and draw early insights into data that would be generated by a multiplex diagnostic platform. Presented at The American Society of Tropical Medicine and Hygiene, December 7, 2008; New Orleans, LA.

Author: Gerlach JL, Waitumbi J, Koros J, et al

Publication date: December 2008

Region: Global

This paper was commissioned as an introductory landscape analysis for the aids2031 Science and Technology Working Group as part of a series of working papers under the aids2031 initiative. The paper builds on other recent landscape analysis work in the fields of HIV prevention technologies, therapeutics, and diagnostics and is intended to serve as a resource on the current status of research and development for biomedical and other technological interventions to prevent, treat, and diagnose HIV/AIDS.

Author: Alcorn K

Publication date: October 2008

Region: Global

Part of series: aids2031 working papers

This special issue of Directions in Global Health describes PATH's work on HIV/AIDS. Featured projects focus on implementing interactive communication techniques that promote healthier behaviors, strengthening health systems to address the dual epidemics of HIV and tuberculosis, protecting youth against HIV, challenging gender norms to reduce the spread of HIV, and advancing innovative technologies for the prevention, diagnosis, and treatment of HIV/AIDS.

Publication date: August 2008

Region: Global

Part of series: Directions in Global Health

Fifteen strains of Escherichia coli from various geographical areas, animal, and soil sources were tested on standard and nonstandard detection assays at temperatures from 23°C to 45°C to test the viability of currently available E. coli tests in low-resource settings. Presented at the American Society for Microbiology Conference, June 1, 2008; Boston, MA.

Author: Allen E, Dillman L, Weigl B

Publication date: June 2008

Region: Global

An overview of a diagnostic platform that PATH is developing based on nucleic-acid amplification that will require no instrumentation. It has the dual purpose of providing molecular diagnostics at the point of care as well as stabilizing nucleic-acid specimens for further analysis via a centralized surveillance system. Presented at the American Association for Clinical Chemistry 40th Annual Oak Ridge Conference, April 17, 2008; San Jose, CA.

Author: Weigl B, Domingo G, Gerlach J, et al

Publication date: April 2008

Region: Global

A report on the selection and evaluation of target markers for a multiplex diagnostic platform under development. Based on the DxBox platform being developed as part of a public-private consortium lead by the University of Washington. Presented at the Molecular Medicine Tri-Conference, March 25, 2008; San Francisco, CA.

Author: Gerlach JL, Anyona S, Koros J, et al

Publication date: March 2008

Region: Global

A report on appropriate product specifications and the challenges of introducing a point-of-care multiplexed diagnostic platform in low-resource settings in developing countries. Based on the DxBox platform being developed as part of a public-private consortium lead by the University of Washington. Presented at: Molecular Medicine Tri-Conference, March 25, 2008; San Francisco, CA.

Author: de los Santos T, Crudder C, Metzler M, Gerlach J, Steele M, Domingo GJ

Publication date: March 2008

Region: Global

A report on selecting and testing phase change materials for their ability to maintain a temperature range for duration sufficient to drive a PCR reaction.  Presented at: Microfluidics, BioMEMS, and Medical Microsystems VI, January 22, 2008; San Jose, CA.

Author: Tang D, LaBarre P, Weigl BH, Stayton PS

Publication date: January 2008

Region: Global

This study assessed the impact of a new sampling device on the performance of a rapid immunochromatographic strip test for chlamydia under development at PATH. The results of endocervical samples collected on flocked swabs were compared to results from those collected with Dacron® swabs. Presented at: 17th Meeting of the International Society for Sexually Transmitted Diseases Research (ISSTDR), July 29, 2007; Seattle, WA

Author: Barfield C, Tinajeros F, Revollo R, et al

Publication date: July 2007

Region: Global

A comparison of the sensitivity and specificity of syndromic management for diagnosis of chlamydia to PCR-based reference methods in a large sample of women in Bolivia. Presented at: International Society for STD Research (ISSTDR), July 26, 2007; Seattle, WA.

Author: Steele M, Tinajeros F, Cohen J, et al

Publication date: July 2007

Region: Global

A visual introduction to the potential advantages of microfluidics as a platform for diagnostic tests in low-resource settings.

Author: Barclay AR

Publication date: May 2007

Region: Global

As part of the Uganda Demographic and Health Survey 2006, this study collected results of Vitamin A deficiency tests from a representative sample of women aged 15–49 and children aged 6–59 months. Presented at: First International Micronutrient Forum, April 16, 2007; Istanbul, Turkey.

Author: Baingana R, Kasozi D, Garrett D, Fort A

Publication date: April 2007

Region: Global

This poster summarizes PATH’s recent activities as part of a consortium lead by the University of Washington to develop the DxBox, a system comprising a portable instrument and low-cost disposable cards. The prototype is being developed to diagnose typhoid fever, dengue fever, rickettsial diseases, malaria, measles, and influenza. PATH’s contributions are immunoassay development, field studies, and user needs assessment. Presented at The American Society of Tropical Medicine and Hygiene (ASTMH), November 12, 2006; Atlanta, GA.

Author: Gerlach JL, Singhal MC, Watts K, et al

Publication date: November 2006

Region: Global

This poster demonstrates the predictive validity of an assay developed by Arbor Vita and PATH. For this study, cervical swab specimens collected from women screened, diagnosed, and managed in rural settings in China were tested for the presence of HPV-16 DNA then examined for HPV16-E6 expression. Results confirmed E6 is a potential diagnostic marker. Presented at: 23rd Papillomavirus Conference and Clinical Workshop, September 1, 2006; Prague, Czech Republic.

Author: Schweizer J, Somoza C, Mahoney C, et al

Publication date: September 2006

Region: Global