This report provides an overview of Nicaragua's health system and diagnostic needs. It is supported by individual case studies on Chagas disease, dengue, and malaria in Nicaragua. These studies focus on several factors influencing the health care system in Nicaragua, including recent trends, regional and national control strategies, financing and partnerships, and the unmet clinical needs associated with each illness.

Author: Sequeira M, Espinoza H, Amador JJ, Domingo G, Quintanilla M, de los Santos T

Publication date: February 2011

Region: Latin America

Part of the Technology Updates series, this fact sheet describes PATH's work to develop technologies that facilitate electricity-free, instrument-free nucleic acid amplification.

Publication date: April 2012

Region: Global

Part of series: Technology Updates

A report on selecting and testing phase change materials for their ability to maintain a temperature range for duration sufficient to drive a PCR reaction.  Presented at: Microfluidics, BioMEMS, and Medical Microsystems VI, January 22, 2008; San Jose, CA.

Author: Tang D, LaBarre P, Weigl BH, Stayton PS

Publication date: January 2008

Region: Global

PATH has demonstrated the use of CaO for heat and a proprietary engineered phase change material (EPCM) to maintain an assay mixture within a narrow temperature range suitable for isothermal amplification. We are currently working to develop, integrate, and validate components of this NAAT kit. Presented at: AACC 42nd Annual Oak Ridge Conference, April 22, 2010; San Jose, CA.

Author: LaBarre P, Beddoe A, Gerlach J, et al

Publication date: April 2010

Region: Global

The PATH-Lemos Chagas rapid test has great potential as a highly sensitive diagnostic test for Chagas disease, suitable for use at the point-of-care.  Presented at: AACC 42nd Annual Oak Ridge Conference, April 22, 2010; San Jose, CA.

Author: Barfield CA, Barney RS, Crudder CH, et al

Publication date: April 2010

Region: Global

This brochure outlines PATH's work in China, with emphasis on public-private partnerships for product development. Areas of focus include vaccines and immunization, health technologies, and women's health.

Publication date: November 2012

Region: Asia

Since 2001, PATH has brought our global health expertise and innovative approaches to the fight against tuberculosis. We work hand in hand with global partners with a special focus on high-burden countries.

Publication date: February 2013

Region: Global

Launched in 2002, this PATH website explores rapid diagnostic tests for infectiuos diseases, and provides information useful to international public health officials.

Publication date: 2008

Region: Global

Part of series: Websites

Part of the Technology Updates series, this fact sheet describes PATH's work to develop a rapid, easy-to-read, low-cost test for malaria.

Publication date: May 2009

Region: Global

Part of series: Technology Updates

Part of the Technology Updates series, this fact sheet describes PATH's work to develop rapid tests for cervical cancer.

Publication date: April 2012

Region: Global

Part of series: Technology Updates

This guide introduces the retinol binding protein enzyme immunoassay (RBP-EIA) to potential advocates and users, and provides information about its prospective role in public health.

Author: Hix J; Levin C; Gorstein J

Publication date: 2003

Region: Global

This document serves as a guide to phlebotomists and a training aid in the proper methods of obtaining blood samples for analysis by the retinol-binding protein enzyme immunoassay (RBP-EIA) used in testing for vitamin A deficiency.

Publication date: 2005

Region: Global

This document summarizes available evidence for the validation and establishment of a rapid, field-based tool for the assessment of vitamin A deficiency using the retinol-binding protein immunoassay (RBP-EIA) test.

Publication date: 2006

Region: Global

This Alliance for Cervical Cancer Prevention fact sheet summarizes evidence published since 2009 on cervical cancer screening approaches for low-resource settings.

Publication date: May 2011

Region: Global

Part of the Technology Updates series, this fact sheet describes PATH's work to develop a rapid, low-cost test to detect vitamin A deficiency.

Publication date: April 2012

Region: Global

Part of series: Technology Updates

Part of the Technology Updates series, this fact sheet describes PATH's work to develop a simple, affordable test for multidrug-resistant tuberculosis.

Publication date: April 2012

Region: Global

Part of series: Technology Updates

Demonstration of the PATH enteric flow-through assay as a rapid and cost effective method for detecting pathogenic bacteria in stool samples in low-resource settings. Presented at the American Association for Clinical Chemistry Oak Ridge Annual Conference, April 17, 2006; San Jose, CA.

Author: Dillman L, Fichtenholtz A, Weigl B

Publication date: April 2006

Region: Global

The pro-viral DNA capture card maintains the fundamental value provided by dried blood spots (ease of collection and transport from remote settings) while reducing the costs and time of performing pediatric HIV testing in the laboratory. Presented at: AACC 42nd Annual Oak Ridge Conference, April 22, 2010; San Jose, CA.

Author: Stevens DS, Barfield CA, Emery S, Overbaugh J, Gerlach J

Publication date: April 2010

Region: Global

An overview of a method of sample preparation by smart polymers for detection in an immunoassay, demonstrated as part of a diagnostics test for Chlamydia trachomatis. Presented at: 38th Annual American Association of Clinical Chemistry (AACC) Oakridge Conference, April 21, 2006; San Jose, CA.

Author: Kulkarni S, Peck R, Barfield C, et al

Publication date: April 2006

Region: Global

This fact sheet describes how the START-UP project is working with private-sector partners to develop two new tests that detect infection with the types of human papillomavirus (HPV) that cause cervical cancer. Designed for use in low-resource settings, these screening tools are an innovative answer to the challenge of early detection of the precursors of cervical cancer.

Publication date: July 2009

Region: Global