This issue of Directions in Global Health features PATH’s work to optimize vaccine supply systems, advance development of malaria vaccine candidates, prevent postpartum hemorrhage to save mothers’ lives, address health needs in Tanzania, and use monitoring and evaluation systems to further PATH’s mission. It also highlights two prestigious awards that PATH recently received.

Publication date: December 2009

Region: Global

Part of series: Directions in Global Health

This issue of PATH Today features a profile of PATH donor Miriam Sevy and her travels with PATH to Kenya, information about our work in Kenya, and an update on our new headquarters building in downtown Seattle. The issue also highlights Ultra Rice® winning the Tech Award, PATH's profile in a new book about the importance of individual donors, and the year-end matching challenge.

Publication date: December 2009

Region: Global

Part of series: PATH Today

This set of fact sheets details technical activities of PATH's Japanese encephalitis project, with an aim to inform future efforts and programs. The fact sheets were developed as a supplement to PATH's Japanese Encephalitis Project: Collaboration and Commitment to Protect Asia's Children. Topics covered include surveillance of disease burden and disability, cost-effectiveness analysis, diagnostics, advocacy, vaccine development, and vaccine introduction.

Publication date: December 2009

Region: Global

The purpose of this project Optimize survey was to obtain input from stakeholders within the Expanded Programme on Immunization in Vietnam about issues and perceptions related to the storage, distribution, and delivery of the current and potential options for human papillomavirus vaccine presentation and packaging.

Publication date: December 2009

Region: Asia

The Optimize project, a collaboration between PATH and the World Health Organization, commissioned this white paper to examine the issues influencing vaccine producer willingness to advance, adopt, and commercialize value-added technologies for vaccines for low-income and lower-middle-income country markets.

Author: Gilchrist S

Publication date: November 2009

Region: Global

Clinical trials are a critical source of data for decisions around vaccine development. This fact sheet provides information about the phases of clinical trials.

Publication date: October 2009

Region: Global

This document provides a brief overview of the Optimize project’s strategy for developing delivery systems that are as advanced and innovative as the vaccines they support. Project Optimize, a collaboration between the World Health Organization and PATH, has been given a unique mandate to think far into the future: to put technological and scientific advances to work, helping define the ideal characteristics and specifications for health products; and to create a vaccine supply chain that is flexible and robust enough to handle an increasingly large and costly portfolio of vaccines.

Publication date: October 2009

Region: Global

This briefing paper underscores the burden of rotavirus and highlights the promise of vaccines to combat the virus as the global health community prepares for worldwide introduction.  

Publication date: September 2009

Region: Global

This edition of PATH Today highlights work to improve children’s health in Nicaragua and Kenya and spotlights PATH's safe water project in Korogocho, a slum near Nairobi, Kenya. It also includes brief updates on the 2009 Breakfast for Global Health, workplace giving, an influenza vaccine study in Africa, and PATH's 2008 annual report.

Publication date: September 2009

Region: Global

Part of series: PATH Today

This issue of Directions in Global Health showcases PATH’s global presence. It highlights work related to influenza in Africa, HIV and AIDS in Eastern Europe,  Japanese encephalitis in Asia, gender-based violence in Latin America and the Caribbean, and diagnostic technologies in North America. The back cover features a map and summary information on PATH’s work around the world.

Publication date: August 2009

Region: Global

Part of series: Directions in Global Health

This article, published in Human Vaccines (Human Vaccines 5:8, 1-7; August 2009), details a collaborative effort between PATH, Arecor, and the University of Colorado Denver School of Pharmacy that has resulted in a new formulation for recombinant hepatitis B vaccine that demonstrates improved stability at elevated temperatures. The formulation exhibited 9-week stability at 55°C and was also shown to be stable at both 37°C and 45°C for at least six months. This new vaccine formulation has the potential to be stored at room temperature for part of its shelf life and will help ensure the potency of the vaccine in areas where the cold chain is insufficient.

Author: Jezek J, Chen D, Watson L, et al.

Publication date: August 2009

Region: Global

Project Optimize, a collaboration between the World Health Organization and PATH, has been given a unique mandate to think far into the future: to put technological and scientific advances to work, helping define the ideal characteristics and specifications for health products; and to create a vaccine supply chain that is flexible and robust enough to handle an increasingly large and costly portfolio of vaccines. This brochure provides an overview of Optimize's areas of focus and activities.

Publication date: August 2009

Region: Global

This film in the BBC World’s Kill or Cure? series uncovers the challenges of preventing and treating cervical cancer in Africa and highlights exciting new opportunities for dramatically reducing the toll of disease. The BBC crew follows Sarah Nyombi—Ugandan member of parliament, trained midwife, and women's health advocate—as she explores the landscape of cervical cancer. The film is available in two versions: 25 minutes and 12 minutes.

Publication date: July 2009

Region: Global

Part of series: Kill or Cure? videos

Diarrheal Disease: Solutions to Defeat a Global Killer presents scientific evidence to support strategies to scale up use of interventions, including safe water, improved sanitation and hygiene, breastfeeding and optimal complementary feeding, rotavirus vaccines, zinc treatment, and oral rehydration therapy/oral rehydration solution. In addition, the report features case studies of on-the-ground programs that bring these tools to communities that need them most. The document is available as one large file or as three smaller files for easier downloading.

Publication date: May 2009

Region: Global

This special issue of Directions in Global Health highlights PATH’s work to advance technologies to improve global health. Featured technologies include low-cost tests to screen for cervical cancer, a new vaccine to protect against meningitis in Africa, products to prevent diarrheal disease, and Ultra Rice food fortification technology. The issue also includes a summary of PATH’s approach to developing and introducing innovative health technologies.

Publication date: May 2009

Region: Global

Part of series: Directions in Global Health

This article, published in Expert Reviews (Expert Rev. Vaccines 8(5), 547-557; May 2009), reviews approaches being used to develop thermostable vaccine formulations that are resistant to damage caused by freezing or excessive heat and could reduce dependence on the cold chain. The article discusses the challenges associated with the implementation of these novel formulations as well as the potential benefits of protecting vaccines from damage caused by breaks in the cold chain.

Author: Chen D, Kristensen D

Publication date: May 2009

Region: Global

This document presents formative research results from PATH's HPV Vaccines: Evidence for Impact project in India. PATH is working with ministries of health and other country partners to develop strategies for introducing vaccines against human papillomavirus (HPV), the primary cause of cervical cancer.

Publication date: March 2009

Region: Asia

This document presents new research results from PATH's HPV Vaccines: Evidence for Impact project in Peru. PATH is working with ministries of health and other country partners to develop strategies for introducing vaccines against human papillomavirus (HPV), the primary cause of cervical cancer.

Publication date: March 2009

Region: Latin America

This document presents new research results from PATH's HPV Vaccines: Evidence for Impact project in Uganda. PATH is working with ministries of health and other country partners to develop strategies for introducing vaccines against human papillomavirus (HPV), the primary cause of cervical cancer.

Publication date: March 2009

Region: Africa

This document presents formative research results from PATH's HPV Vaccines: Evidence for Impact project in Vietnam. PATH is working with ministries of health and other country partners to develop strategies for introducing vaccines against human papillomavirus (HPV), the primary cause of cervical cancer.

Publication date: March 2009

Region: Asia