Human papillomavirus (HPV) vaccine is intended to prevent cervical cancer. As part of project Optimize, a two-year HPV vaccine demonstration project is being conducted to demonstrate how existing delivery systems can be adapted to successfully provide HPV vaccine to young adolescent girls. HPV vaccine is a strong candidate for out-of-the-cold-chain use given its characteristics of high heat stability and freeze sensitivity.

Author: Robertson J, Vu H, Le N, et al.

Publication date: July 2010

Region: Global

This poster describes the AV Avantage HPV E6 Test and the results from a small clinical pilot study. The AV Avantage HPV E6 Test uses high affinity mAb for the specific capture and detection of high-risk HPV-E6 oncoproteins in a lateral flow–based format. Presented at: 26th International Papillomavirus Conference, July 3, 2010; Montreal, Canada.

Author: Berard-Bergery M, Bisht A, Ho M, et al

Publication date: July 2010

Region: Global

In July 2010, project Optimize held workshops in Washington, DC, and Seattle, WA, to engage stakeholders from a wide variety of organizations. The workshops discussed developing-country immunization systems and sought participant perspectives on the desired future state of the systems. This document provides a summary of the workshops.

Publication date: July 2010

Region: Global

This fact sheet from the Global Health Technologies Coalition examines the role of innovation in international development and makes recommendations to elevate global health research in the foreign aid reform process.

Publication date: July 2010

Region: North America and Europe

PATH conducted a market study in 2008 to identify neonatal resuscitators available in the Southern African Development Community region. These resuscitators are included in this region-specific version of Practical Selection of Neonatal Resuscitators. All resuscitators identified were bag-and-mask designs. Also included are two devices that offer a tube-and-mask design. This guide presents the criteria used during the device evaluation, evaluation results for each device, and suggestions for choosing a resuscitator. The guide is available in two formats: one for booklet-style printing and one for onscreen viewing.

Publication date: June 2010

Region: Africa

Part of series: Oxygen technologies

This handbook is a practical guide developed for site-level microbicide researchers, communicators, advocates, and others working on HIV prevention trials in developing countries. It includes context-specific case studies and practical insights from actual clinical trial communications initiatives. It is being updated to include work sheets and slide sets. To apply for a complimentary copy, please email Jacqueline Borodan at jacqueline@avac.org for detailed instructions.

Author: Robinson E, Baron D, Heise L, Moffett J, Harlan SV

Publication date: May 2010

Region: Global

This issue of Directions in Global Health features PATH’s work to improve maternal and newborn health around the world. Articles cover innovative technologies to save newborns, better nutrition for mothers and children, methods to make childbirth safer, and women’s access to more options for family planning.

Publication date: May 2010

Region: Global

Part of series: Directions in Global Health

PATH has worked to improve maternal and child health, nutrition, and family planning in developing countries for more than 30 years. This brochure describes our integrated approach to reach mothers, children, and communities with key innovations for strong futures.

Publication date: May 2010

Region: Global

Part of the Technology Updates series, this fact sheet describes PATH's work on Uniject for use with injectable contraceptives.

Publication date: May 2010

Region: Global

Part of series: Technology Updates

Part of the Technology Updates series, this fact sheet describes PATH's current project to improve packaging of nevirapine used to prevent mother-to-child transmission of HIV.

Publication date: May 2010

Region: Global

Part of series: Technology Updates

PATH has evaluated a variety of reusable neonatal resuscitators, including both bag-and-mask and tube-and-mask designs. This guide is divided into two sections: the first identifies resuscitators that are priced at less than US$30 each, and the second identifies those that are priced at more than $30 each. It also describes the criteria used during the device evaluation, evaluation results for each device, and suggestions for choosing a resuscitator. The guide is available in two formats: one for booklet-style printing and one for onscreen viewing.

Publication date: May 2010

Region: Global

Part of series: Oxygen technologies

This publication describes the public health potential of multipurpose prevention technologies -- that is, technologies that prevent unintended pregnancy; sexually transmitted infections, including HIV; and/or other reproductive tract infections. While a few such technologies exist, greater collaboration and resources are needed to accelerate research and development efforts and bring new technologies into widespread use.

Author: Holt BY, Kilbourne-Brook M, Cohen J, Burns M

Publication date: May 2010

Region: Global

This report covers a 2009 consultation in Kampala, Uganda, that was convened by the Global Campaign for Microbicides, the Joint UN Programme on HIV/AIDS, and the US Centers for Disease Control and Prevention. It includes recommendations related to key ethical and practical questions on the design and implementation of clinical trials.

Author: McGrory E, Philpott S, Hankins C, Paxton L, Heise L

Publication date: May 2010

Region: Global

Both Iran and Sudan utilize an alarm-based temperature recording system to monitor the performance of their national immunization cold stores. To better the utility and application of such systems in other countries, this project Optimize report documents the benefits, challenges, and advantages of both Iran’s and Sudan’s systems.

Author: Haghgou, M

Publication date: May 2010

Region: Global

In 2010, the World Health Organization (WHO) issued a new policy to guide activities for controlling tuberculosis (TB) infection. This report provides guidance on advocacy for political and financial support for TB infection control from donors and countries, widespread adoption of the WHO policy, and incorporation of it into national and local policies. The report also addresses advocacy for linkages with civil society organizations in the field to ensure demand for and implementation of the WHO policy to protect health workers, patients, and communities from TB transmission.

Publication date: April 2010

Region: Global

PATH conducted a detailed cost analysis in Nicaragua to understand the costs of each step required to perform viral load testing, beginning at the patient’s house and continuing to when the viral load testing result is actually communicated back to the patient’s antiretroviral therapy care provider. Using this information, PATH has developed a low-cost technology to extract HIV viral RNA at the point of care and stabilize it, removing the need for cold chain preservation of the specimen. Presented at: AACC 42nd Annual Oak Ridge Conference, April 22, 2010; San Jose, CA.

Author: Stevens DS, Beddoe AG, Hubbard L, et al

Publication date: April 2010

Region: Global

PATH’s Safe Water Project is implementing an innovative safe water project with the goal of enabling commercial enterprises to produce, distribute, sell, and maintain effective household water treatment and storage products for low-income populations in Vietnam and other developing countries. This project brief summarizes the results of three studies—a consumer study, a product scan, and an analysis of distribution channels—that were conducted from April to December 2008 to inform the development and implementation of a safe water pilot project in Vietnam.

Author: Kols, A

Publication date: April 2010

Region: Asia

This document identifies key steps and information relevant to the development and implementation of a national procurement policy on safe-injection equipment. The intention is to increase patient and health worker safety, and especially to avoid medical transmission of bloodborne infections such as HIV, hepatitis B, and hepatitis C.

Publication date: April 2010

Region: Global

This report from the vaccine technologies team at PATH presents results from an economic model that calculates the costs involved in delivering IPV vaccine in Indian immunization clinics according to three strategies: (1) intradermal delivery of reduced volumes of vaccine per dose, (2) use of adjuvants to allow a reduced IPV antigen content per dose, and (3) reduction of the number of doses per IPV immunization schedule. The strategies include delivery by standard technique and with alternative delivery devices.

Author: Hickling J, Jones R, Nundi N, Zehrung D

Publication date: April 2010

Region: Global

This job aid was developed to support training of small-scale incinerator operators and provides key message about how to perform regular maintenance. Regular maintenance is critical to ensuring the incinerator functions optimally for the projected life of the unit.

Publication date: April 2010

Region: Global