This brief describes results from an analysis conducted by PATH comparing the current intramuscular version of depot medroxyprogesterone acetate (DMPA) injectable contraceptive compared with a new formulation packaged in the Uniject™ injection system. The analysis focused on waste management implications, identifying key quantitative and qualitative differences between the two products.

Publication date: February 2011

Region: Global

This brief summarizes key findings from a literature review conducted by PATH to identify published and gray literature reporting international experiences with the Uniject™ injection system. The findings shed light on user acceptability and highlight potential cost savings in terms of training time, waste management, and reduction in drug wastage when Uniject is used instead of a standard autodisable syringe. This document synthesizes the experience and evidence on the use of Uniject worldwide with medicines such as the injectable contraceptive Cyclofem®, hepatitis B and tetanus toxoid vaccines, as well as the drug oxytocin, which is used to prevent postpartum hemorrhage.

Publication date: February 2011

Region: Global

In preparation for developing country introduction, PATH conducted a rapid assessment of the feasibility and appropriateness of introducing the SILCS diaphragm into the family planning method mix in Uganda. SILCS, a nonhormonal barrier method, is an opportunity to expand women’s options for contraceptive protection in low-resource settings.

Publication date: December 2010

Region: Africa, Global

This handbook is a practical guide developed for site-level microbicide researchers, communicators, advocates, and others working on HIV prevention trials in developing countries. It includes context-specific case studies and practical insights from actual clinical trial communications initiatives. It is being updated to include work sheets and slide sets. To apply for a complimentary copy, please email Jacqueline Borodan at jacqueline@avac.org for detailed instructions.

Author: Robinson E, Baron D, Heise L, Moffett J, Harlan SV

Publication date: May 2010

Region: Global

This publication describes the public health potential of multipurpose prevention technologies -- that is, technologies that prevent unintended pregnancy; sexually transmitted infections, including HIV; and/or other reproductive tract infections. While a few such technologies exist, greater collaboration and resources are needed to accelerate research and development efforts and bring new technologies into widespread use.

Author: Holt BY, Kilbourne-Brook M, Cohen J, Burns M

Publication date: May 2010

Region: Global

This report covers a 2009 consultation in Kampala, Uganda, that was convened by the Global Campaign for Microbicides, the Joint UN Programme on HIV/AIDS, and the US Centers for Disease Control and Prevention. It includes recommendations related to key ethical and practical questions on the design and implementation of clinical trials.

Author: McGrory E, Philpott S, Hankins C, Paxton L, Heise L

Publication date: May 2010

Region: Global

This edition of PATH Today features our work in women's health and with the Entre Amigos project in Nicaragua and spotlights Margarita Quintanilla, PATH's Nicaragua country program leader. The issue also highlights PATH's breakthrough development of freeze-stable vaccines, an award for PATH vice president Dr. Michael Free, and the McKinstry Co. Charitable Foundation's commitment to health.

Publication date: May 2009

Region: Global

Part of series: PATH Today

These executive summaries reveal findings and recommendations from initial assessments conducted in Bangladesh, Ethiopia, Kenya, Malawi, Nigeria, Pakistan, Rwanda, and Senegal. These countries were evaluated in terms of service delivery, supply systems, and stakeholder perspectives with respect to the feasibility and appropriateness of introducing depo-subQ in Uniject.

Publication date: 2009

Region: Global

This issue of PATH Today features our Sure Start project, new study results on the Ultra Rice technology, and brief updates on PATH's Woman's Condom, the Washington Global Health Alliance, and more. The issue also includes a profile on PATH donor Jay Ingram.

Publication date: September 2008

Region: Global

Part of series: PATH Today

This report provides an overview of the status of civil-society engagement in each phase of microbicide research, development, and introduction and identifies the resources and specific action steps needed to move from the current level of engagement to where we need to be. .

Author: Forbes A, Sylla L, Yassky R

Publication date: February 2008

Region: Global

This special issue of Directions in Global Health features PATH's work in women's health. Featured projects include Sure Start; the Maternal and Newborn Health Technology Initiative; the Prevention of Postpartum Hemorrhage Initiative; Global Campaign for Microbicides; SILCS diaphragm; the PATH Woman's Condom; microbicide applicators; AIDS, Population, and Health Integrated Assistance II Western Province; and Spring Bud Healthy Development.

Publication date: September 2007

Region: Global

Part of series: Directions in Global Health

This issue of Outlook provides new information about the female condom as presented at the September 2005 Global Consultation on the Female Condom. Topics include evidence of the female condom's effectiveness for prevention of STIs and pregnancy, issues related to expanding access and use, and gaps in the knowledge base. Successful program examples and a detailed table of female condoms currently available or under development are also presented.

Author: Shane B

Publication date: May 2006

Region: Global

Part of series: Outlook

More than 100 experts from 15 countries met in Baltimore, Maryland, in September 2005 at the Global Consultation on the Female Condom (GCFC) to discuss the status of the female condom worldwide and to develop a plan of action to build support for the method. This document answers key questions about the female condom and builds on the momentum created at the GCFC by presenting evidence of the female condom's effectiveness and impact, identifying current challenges to wider use, and indicating the steps that need to be taken now to develop strong female condom programs worldwide.

Publication date: 2006

Region: Global

This document provides an historical profile on the design of PATH's SILCS diaphragm, including clinical evaluations, user acceptability studies, and product features, specifications, and benefits.

Publication date: 2006

Region: Global

Publication date: September 2005

Region: Global

Part of series: PATH Today

The April 2005 issue of Directions in Global Health features five PATH projects: efforts to improve health among migrant communities in China, Thailand, and Cambodia; the Global Campaign for Microbicides, PATH's Woman's Condom, procurement of safe-injection supplies under the PEPFAR program, and the Rotavirus Vaccine Program.

Author: PATH

Publication date: April 2005

Region: Global

Part of series: Directions in Global Health

On October 23–24, 2003, the Global Campaign for Microbicides brought together 64 people from 12 countries to rethink the issues and ethical dilemmas facing the field of microbicide development. The consultation comprised a broad range of stakeholders, including advocates, ethicists, clinical investigators, community members, drug regulatory authorities, and past participants in microbicide clinical trials. The report is available as one large file and as multiple smaller files for easier downloading.

Publication date: March 2005

Region: Global

This document provides historical information on the PATH-designed Woman's Condom, which could help couples around the world reduce their risk of HIV, other sexually transmitted infections, and unintended pregnancy.

Publication date: 2005

Region: Global

This poster was presented by PATH's India Microbicide Project at the Microbicides 2004 Conference in London. It describes ciclopiroxolamine, a vaginal product with microbicide potential. Ciclopiroxolamine is a unique microbicide candidate with a long history of proven safety in clinical use as a vaginal and skin product with anti-infective properties. It is already formulated, manufactured, and marketed worldwide in vaginal products. (This project was active from January 2002 to June 2006. It is on hold pending support to obtain additional data on anti-HIV activity.)

Author: Zaneveld LJ; Waller D; Sellors J; Camus-Bablon F

Publication date: 2004

Region: Asia

Filmed in several locations across the world, this short documentary is a tool for organizing and creating awareness around the increasing rates of HIV and sexually transmitted infections among women and the importance of advocacy for microbicides. The personal stories portrayed in In Women’s Hands speak to the need for microbicides and the importance for leadership on this issue.

Publication date: 2004

Region: Global