This issue of Directions in Global Health highlights PATH’s work to reduce the global burden of HIV/AIDS. It describes how PATH strengthens community-based responses; addresses gender norms to reduce HIV risk; integrates services for maximum effectiveness against HIV, tuberculosis, and other health challenges; advances needed technologies; and evaluates project impact. In addition, Dr. Julie Pulerwitz offers her perspective on turning the tide against AIDS.

Publication date: July 2012

Region: Global

Part of series: Directions in Global Health

Since 2003, PATH has conducted a wide range of activities to inform and advance the development of novel microbicide-delivery methods that are safe, acceptable, affordable, and appropriate for use in low-resource settings. This fact sheet describes how PATH identified a paper, user-filled applicator as an important, practical option that could help reduce cost per dose, thereby improving access to microbicide products in impoverished regions most affected by HIV.

Publication date: June 2012

Region: Global

The Caucus on New and Underused Reproductive Health Technologies is a community of practice established under the auspices of the Reproductive Health Supplies Coalition, for which PATH serves as Secretariat. Caucus members developed this series of peer-reviewed briefs on underused reproductive health technologies. Responsibility for the selection and contents of the briefs rests solely with the Caucus and does not imply endorsement of any single technology by the Coalition or its wider membership. The briefs are available in one combined file as well as separately. For more information on the Caucus, please visit http://rhsupplies.org/index.php?id=894 or contact secretariat@rhsupplies.org.

Publication date: May 2012

Region: Global

This brochure outlines PATH's work to improve health in South Africa by bringing effective interventions to the people who need them most. Our interventions make birth safer, enhance infant and young child health, combat HIV/AIDS, strengthen health systems, and support improved sanitation.

Publication date: October 2011

Region: Africa

Part of series: Country brochures

This literature review details the key findings on the feasibility and acceptability of home delivery of depo-subQ provera 104™ in the Uniject™ injection system  (depo-subQ in Uniject). The review focused on self-injection and looked specifically at subcutaneous depot medroxyprogesterone acetate (DMPA) compared to the intramuscular formulation; considerations for home administration of injectable contraception, particularly in low-resource settings; and identified research needs for home administration, including self-injection, of depo-subQ in Uniject. A six-page briefing summary of this review is also available.

Author: Keith BM

Publication date: July 2011

Region: Global

Featured in this issue of PATH Today are stories and photos from the historic launch of a new meningitis vaccine in Burkina Faso. Also included are updates on projects receiving support from the Catalyst Fund, announcement of a seventh consecutive top rating from Charity Navigator, and a spotlight on Breakfast for Global Health sponsor CB Richard Ellis.

Publication date: May 2011

Region: Global

Part of series: PATH Today

This brief summarizes the strategic demand models developed by PATH and the Futures Institute for the injectable contraceptive depo-subQ provera 104™ in the Uniject™ injection system (depo-subQ in Uniject) in Kenya, Malawi, Pakistan, Rwanda, and Senegal. These models will help inform global and country introduction planning for depo-subQ in Uniject.

Publication date: February 2011

Region: Global

This brief describes results from an analysis conducted by PATH comparing the current intramuscular version of depot medroxyprogesterone acetate (DMPA) injectable contraceptive compared with a new formulation packaged in the Uniject™ injection system. The analysis focused on waste management implications, identifying key quantitative and qualitative differences between the two products.

Publication date: February 2011

Region: Global

This brief summarizes key findings from a literature review conducted by PATH to identify published and gray literature reporting international experiences with the Uniject™ injection system. The findings shed light on user acceptability and highlight potential cost savings in terms of training time, waste management, and reduction in drug wastage when Uniject is used instead of a standard autodisable syringe. This document synthesizes the experience and evidence on the use of Uniject worldwide with medicines such as the injectable contraceptive Cyclofem®, hepatitis B and tetanus toxoid vaccines, as well as the drug oxytocin, which is used to prevent postpartum hemorrhage.

Publication date: February 2011

Region: Global

In preparation for developing country introduction, PATH conducted a rapid assessment of the feasibility and appropriateness of introducing the SILCS diaphragm into the family planning method mix in Uganda. SILCS, a nonhormonal barrier method, is an opportunity to expand women’s options for contraceptive protection in low-resource settings.

Publication date: December 2010

Region: Africa, Global

This handbook is a practical guide developed for site-level microbicide researchers, communicators, advocates, and others working on HIV prevention trials in developing countries. It includes context-specific case studies and practical insights from actual clinical trial communications initiatives. It is being updated to include work sheets and slide sets. To apply for a complimentary copy, please email Jacqueline Borodan at jacqueline@avac.org for detailed instructions.

Author: Robinson E, Baron D, Heise L, Moffett J, Harlan SV

Publication date: May 2010

Region: Global

This publication describes the public health potential of multipurpose prevention technologies -- that is, technologies that prevent unintended pregnancy; sexually transmitted infections, including HIV; and/or other reproductive tract infections. While a few such technologies exist, greater collaboration and resources are needed to accelerate research and development efforts and bring new technologies into widespread use.

Author: Holt BY, Kilbourne-Brook M, Cohen J, Burns M

Publication date: May 2010

Region: Global

This report covers a 2009 consultation in Kampala, Uganda, that was convened by the Global Campaign for Microbicides, the Joint UN Programme on HIV/AIDS, and the US Centers for Disease Control and Prevention. It includes recommendations related to key ethical and practical questions on the design and implementation of clinical trials.

Author: McGrory E, Philpott S, Hankins C, Paxton L, Heise L

Publication date: May 2010

Region: Global

This edition of PATH Today features our work in women's health and with the Entre Amigos project in Nicaragua and spotlights Margarita Quintanilla, PATH's Nicaragua country program leader. The issue also highlights PATH's breakthrough development of freeze-stable vaccines, an award for PATH vice president Dr. Michael Free, and the McKinstry Co. Charitable Foundation's commitment to health.

Publication date: May 2009

Region: Global

Part of series: PATH Today

These executive summaries reveal findings and recommendations from initial assessments conducted in Bangladesh, Ethiopia, Kenya, Malawi, Nigeria, Pakistan, Rwanda, and Senegal. These countries were evaluated in terms of service delivery, supply systems, and stakeholder perspectives with respect to the feasibility and appropriateness of introducing depo-subQ in Uniject.

Publication date: 2009

Region: Global

This issue of PATH Today features our Sure Start project, new study results on the Ultra Rice technology, and brief updates on PATH's Woman's Condom, the Washington Global Health Alliance, and more. The issue also includes a profile on PATH donor Jay Ingram.

Publication date: September 2008

Region: Global

Part of series: PATH Today

This report provides an overview of the status of civil-society engagement in each phase of microbicide research, development, and introduction and identifies the resources and specific action steps needed to move from the current level of engagement to where we need to be. .

Author: Forbes A, Sylla L, Yassky R

Publication date: February 2008

Region: Global

This special issue of Directions in Global Health features PATH's work in women's health. Featured projects include Sure Start; the Maternal and Newborn Health Technology Initiative; the Prevention of Postpartum Hemorrhage Initiative; Global Campaign for Microbicides; SILCS diaphragm; the PATH Woman's Condom; microbicide applicators; AIDS, Population, and Health Integrated Assistance II Western Province; and Spring Bud Healthy Development.

Publication date: September 2007

Region: Global

Part of series: Directions in Global Health

This issue of Outlook provides new information about the female condom as presented at the September 2005 Global Consultation on the Female Condom. Topics include evidence of the female condom's effectiveness for prevention of STIs and pregnancy, issues related to expanding access and use, and gaps in the knowledge base. Successful program examples and a detailed table of female condoms currently available or under development are also presented.

Author: Shane B

Publication date: May 2006

Region: Global

Part of series: Outlook

More than 100 experts from 15 countries met in Baltimore, Maryland, in September 2005 at the Global Consultation on the Female Condom (GCFC) to discuss the status of the female condom worldwide and to develop a plan of action to build support for the method. This document answers key questions about the female condom and builds on the momentum created at the GCFC by presenting evidence of the female condom's effectiveness and impact, identifying current challenges to wider use, and indicating the steps that need to be taken now to develop strong female condom programs worldwide.

Publication date: 2006

Region: Global