PATH
Menu

Filter browse results

Total results with these characteristics: 185

Subject: Health technologies > Vaccine delivery

Page 8 of 10
A Heat-Stable Hepatitis B Vaccine Formulation

This article, published in Human Vaccines (Human Vaccines 5:8, 1-7; August 2009), details a collaborative effort between PATH, Arecor, and the University of Colorado Denver School of Pharmacy that has resulted in a new formulation for recombinant hepatitis B vaccine that demonstrates improved stability at elevated temperatures. The formulation exhibited 9-week stability at 55°C and was also shown to be stable at both 37°C and 45°C for at least six months. This new vaccine formulation has the potential to be stored at room temperature for part of its shelf life and will help ensure the potency of the vaccine in areas where the cold chain is insufficient.

Author: Jezek J, Chen D, Watson L, et al.

Publication date: August 2009

Region: Global

Intradermal Delivery of Vaccines: A Review of the Literature and the Potential for Development for Use in Low- and Middle-Income Countries

Produced by project Optimize and the vaccine technologies team at PATH, this report: (1) summarizes the clinical evidence supporting the intradermal route for vaccine administration and the devices being developed for this purpose; (2) determines whether intradermal delivery broadly holds promise for vaccine applications for low- and middle-income countries in the future; and (3) begins to prioritize vaccine targets and device strategies that best fit the public health needs in these countries and likely merit further investigation. The document is available as one large file or as four smaller files for easier downloading.

Publication date: August 2009

Region: Global

Optimize: Immunization Systems and Technologies for Tomorrow

Project Optimize, a collaboration between the World Health Organization and PATH, has been given a unique mandate to think far into the future: to put technological and scientific advances to work, helping define the ideal characteristics and specifications for health products; and to create a vaccine supply chain that is flexible and robust enough to handle an increasingly large and costly portfolio of vaccines. This brochure provides an overview of Optimize's areas of focus and activities.

Publication date: August 2009

Region: Global

Opportunities and Challenges of Developing Thermostable Vaccines

This article, published in Expert Reviews (Expert Rev. Vaccines 8(5), 547-557; May 2009), reviews approaches being used to develop thermostable vaccine formulations that are resistant to damage caused by freezing or excessive heat and could reduce dependence on the cold chain. The article discusses the challenges associated with the implementation of these novel formulations as well as the potential benefits of protecting vaccines from damage caused by breaks in the cold chain.

Author: Chen D, Kristensen D

Publication date: May 2009

Region: Global

PATH Today (Spring 2009)

This edition of PATH Today features our work in women's health and with the Entre Amigos project in Nicaragua and spotlights Margarita Quintanilla, PATH's Nicaragua country program leader. The issue also highlights PATH's breakthrough development of freeze-stable vaccines, an award for PATH vice president Dr. Michael Free, and the McKinstry Co. Charitable Foundation's commitment to health.

Publication date: May 2009

Region: Global

Part of series: PATH Today

Shaping a Strategy to Introduce HPV Vaccines in India

This document presents formative research results from PATH's HPV Vaccines: Evidence for Impact project in India. PATH is working with ministries of health and other country partners to develop strategies for introducing vaccines against human papillomavirus (HPV), the primary cause of cervical cancer.

Publication date: March 2009

Region: Asia

Shaping a Strategy to Introduce HPV Vaccines in Peru

This document presents new research results from PATH's HPV Vaccines: Evidence for Impact project in Peru. PATH is working with ministries of health and other country partners to develop strategies for introducing vaccines against human papillomavirus (HPV), the primary cause of cervical cancer.

Publication date: March 2009

Region: Latin America

Shaping a Strategy to Introduce HPV Vaccines in Uganda

This document presents new research results from PATH's HPV Vaccines: Evidence for Impact project in Uganda. PATH is working with ministries of health and other country partners to develop strategies for introducing vaccines against human papillomavirus (HPV), the primary cause of cervical cancer.

Publication date: March 2009

Region: Africa

Shaping a Strategy to Introduce HPV Vaccines in Vietnam

This document presents formative research results from PATH's HPV Vaccines: Evidence for Impact project in Vietnam. PATH is working with ministries of health and other country partners to develop strategies for introducing vaccines against human papillomavirus (HPV), the primary cause of cervical cancer.

Publication date: March 2009

Region: Asia

Development of a Freeze-Stable Formulation for Vaccines Containing Aluminum Salt Adjuvants

This article was published in Vaccine, Volume 27, Issue 1, Jones Braun L, Tyagi A, Perkins S, et al, Development of a freeze-stable formulation for vaccines containing aluminum salt adjuvants, pp. 72-79, Copyright Elsevier (2009). The journal may be accessed at http://www.sciencedirect.com/science/journal/0264410X

Author: Jones Braun L, Tyagi A, Perkins S, et al

Publication date: January 2009

Region: Global

PATH Today (Winter 2008)

This issue of PATH Today features a profile of PATH donor Diana Carey and her family, a report from PATH Journeys travelers to Vietnam, and brief updates on the 25th anniversary of Outlook, Forbes’ "most efficient charities" list, and more. The issue also highlights the year-end matching challenge.

Publication date: December 2008

Region: Global

Part of series: PATH Today

Use of Vaccines Outside of the Cold Chain: A Literature Review

This project Optimize study is a compilation of the literature available on the use of vaccines outside of the cold chain. Most of the studies analyzed in this review focus on hepatitis B, with one exception—a study examining meningococcal C vaccine.

Author: Villadiego S

Publication date: August 2008

Region: Global

Landscape Analysis: Trends in Vaccine Availability and Novel Vaccine Delivery Technologies: 2008–2025

This project Optimize landscape analysis identifies trends in the availability of vaccines and novel vaccine delivery technologies that are and will be of relevance to low- and middle-income countries from present through 2025. The document is available as one large file or as three smaller sections for easier downloading.

Publication date: July 2008

Region: Global

Landscape Analysis: Analysis of EVSM Indicators

The Effective Vaccine Stores Management (EVSM) assessment tool was created to help countries and agencies evaluate critical components of the country’s primary vaccine store. To date, 57 countries have completed the EVSM assessment. This project Optimize report evaluates 42 EVSM assessment spreadsheets.

Publication date: June 2008

Region: Global

Landscape Analysis: Cool Chain Technologies

Technologies related to the temperature control of vaccines during the distribution process are essential to the cool chain. This project Optimize report provides a landscape analysis of these technologies and their appropriateness for use with vaccines in the developing world.

Publication date: June 2008

Region: Global

Directions in Global Health (Volume 5, Issue 1)

This issue of Directions in Global Health profiles our effort to expand access to safe water, particularly in India; a project to improve nutrition for infants and young children; our thermostable vaccine work; surveillance activities for Japanese encephalitis; and our work under the Reproductive Health Supplies Coalition.

Publication date: May 2008

Region: Global

Part of series: Directions in Global Health

Directions in Global Health (Volume 4, Issue 3)

This issue of Directions in Global Health profiles five aspects of PATH's work: our regional efforts to control tuberculosis, the development of and new applications for the Uniject device, a study evaluating storage of hepatitis B vaccine outside of the cold chain, promotion of condom use among young people, and PATH's procurement team.

Publication date: January 2008

Region: Global

Part of series: Directions in Global Health

Introduction of Rotavirus Vaccine with Support from the GAVI Alliance: Information to Assist the National Decision-Making and Application Process

This guide summarizes considerations for rotavirus vaccine introduction in Eastern European countries eligible for support from the GAVI Alliance.

Publication date: December 2007

Region: Eastern Europe

Directions in Global Health (Volume 4, Issue 1)

This special issue of Directions in Global Health highlights PATH's vaccine partnership efforts: PATH Malaria Vaccine Initiative (MVI), pneumococcal vaccine development project, Meningitis Vaccine Project, cervical cancer vaccine project, and Rotavirus Vaccine Program. The issue also features a case study of the vaccine vial monitor.

Author: PATH

Publication date: May 2007

Region: Global

Part of series: Directions in Global Health

Increasing Hepatitis B Vaccine Coverage Rates by Implementing an Out-of-the-Cold-Chain Strategy

In areas such as Southeast Asia with a high incidence of mother-to-child transmission of hepatitis B, WHO recommends a birth dose of the vaccine for all children. Hepatitis B vaccine is typically kept refrigerated, within the cold chain. This fact sheet reports on an effort by PATH and Vietnam's National Expanded Program on Immunization to increase coverage rates for the vaccine in Thanh Hoa Province through a new strategy?storing the vaccine outside of the cold chain and using vaccine vial monitors to confirm that the vaccine continued to confer effective protection.

Publication date: 2007

Region: Asia

Page 8 of 10