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Total results with these characteristics: 99

Subject: Health technologies > Diagnostic technologies
Publication date: All

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Detection of High-Risk HPV-E6 Oncoprotein in Low and High-Grade Cervical Intraepithelial Neoplasia (CIN): Emerging Evidence for Predictive Validity

This poster demonstrates the predictive validity of an assay developed by Arbor Vita and PATH. For this study, cervical swab specimens collected from women screened, diagnosed, and managed in rural settings in China were tested for the presence of HPV-16 DNA then examined for HPV16-E6 expression. Results confirmed E6 is a potential diagnostic marker. Presented at: 23rd Papillomavirus Conference and Clinical Workshop, September 1, 2006; Prague, Czech Republic.

Author: Schweizer J, Somoza C, Mahoney C, et al

Publication date: September 2006

Region: Global

The Detection of HIV-1 Proviral DNA in Less Than 20 Minutes

Recombinase Polymerase Amplification (RPA) assays were designed to detect pol from HIV-1BRU proviral DNA using real-time or immunochromatographic strip detection of RPA amplicons. Presented at: AACC 41st Annual Oak Ridge Conference, April 16, 2009; Baltimore, MD.

Author: Boyle DS, Lehman DA, Overbaugh J, et al

Publication date: April 2009

Region: Global

Developing a Lateral Flow Strip Test for E6 Oncoprotein to Identify Cervical Intraepithelial Neoplasia (CIN) at Increased Risk of Progression to Cervical Cancer

This poster outlines the evaluation of two immunochromatographic strip test platforms for the best limit of detection: one uses an antibody colloidal gold conjugate which is visually interpreted yielding qualitative results, and the other uses an antibody paramagnetic particle conjugate which is read by an instrument yielding quantitative results. The resulting limits of detection of these two methods are compared to the target limit of detection for an E6 assay of ~50 pg. Presented at: 23rd Papillomavirus Conference and Clinical Workshop, September 1, 2006; Prague, Czech Republic.

Author: Peck R, Weigl BH, Schweizer J, et al

Publication date: September 2006

Region: Global

Developing a Point-of-Care Multiplexed Diagnostic System for Low-Resource Settings in Developing Countries

A report on the selection and evaluation of target markers for a multiplex diagnostic platform under development. Based on the DxBox platform being developed as part of a public-private consortium lead by the University of Washington. Presented at the Molecular Medicine Tri-Conference, March 25, 2008; San Francisco, CA.

Author: Gerlach JL, Anyona S, Koros J, et al

Publication date: March 2008

Region: Global

Developing a Point-of-Care Multiplexed Diagnostic System for Low-Resource Settings in Developing Countries: Challenges in Understanding Market and User Requirements

A report on appropriate product specifications and the challenges of introducing a point-of-care multiplexed diagnostic platform in low-resource settings in developing countries. Based on the DxBox platform being developed as part of a public-private consortium lead by the University of Washington. Presented at: Molecular Medicine Tri-Conference, March 25, 2008; San Francisco, CA.

Author: de los Santos T, Crudder C, Metzler M, Gerlach J, Steele M, Domingo GJ

Publication date: March 2008

Region: Global

Development of a Diagnostic Assay Based on the Binding of High-Risk HPV-E6 Oncoproteins to PDZ

A prototype of a novel diagnostic assay for cervical pre-cancer and cancer has been developed in both a sandwich ELISA-based and a lateral flow–based format (“strip test”). The test specifically detects presence of high-risk HPV-E6 and therefore promises to be of higher predictive value for cervical pre-cancer and cancer than other assays detecting merely presence of HPV. Presented at: 22rd International Papillomavirus Conference and Clinical Workshop, September 1, 2006; Vancouver, Canada.

Author: Schweizer J, Somoza C, Peck R, et al

Publication date: September 2006

Region: Global

Device for Automated Capture of E. coli O157:H7 From Feces: Feasibility for Point-of-Care Detection

This poster reports progress incorporating magnetic beads within a unique lab card that permits efficient capture and enrichment of E. coli O157:H7 from feces. Presented at the 106th General Meeting of the American Society for Microbiology, May 21, 2006; Orlando, FL.

Author: Gerdes JC, Weigl BH, Yager P

Publication date: May 2006

Region: Global

Diagnosis of Plasmodium Falciparum Malaria in the Lao People's Democratic Republic (PDR) Using Rapid Diagnostic Assays

This study evaluated the performance of PATH’s rapid diagnostic assay detecting histidine rich protein 2 (HRP-2) antigen when used by local health care providers in a rural field setting in Lao PDR and examined rapid diagnostic assays as a strategy to identify participants for in vivo treatment trials in a rural field site.

Author: Labbé AC, Pillai DR, Hongvangthong B, et al

Publication date: January 1999

Region: Global

Diagnostic Technologies Website

This website about the diagnostics work within the Technology Solutions program provides an overview of the group and its featured projects. See other PATH program websites.

Publication date: 2014

Region: Global

Part of series: Program websites

Directions in Global Health (Volume 10, Issue 1)

This issue of Directions in Global Health features work by OneWorld Health, PATH’s drug development program, to lead development of innovative methods to enhance the supply of artemisinin, a key ingredient in malaria treatments. It includes a commentary by Dr. Ponni Subbiah, who directs PATH’s drug development efforts. Other articles cover work to improve cervical cancer screening, protect infants from respiratory syncytial virus, increase access to family planning, and strengthen and expand use of human milk banking.

Publication date: May 2013

Region: Global

Part of series: Directions in Global Health

Directions in Global Health (Volume 10, Issue 2)

This issue of Directions in Global Health highlights PATH’s work over a decade to improve control of Japanese encephalitis and make an affordable vaccine from China widely available. It includes an editorial by Dr. Kathy Neuzil, who directs PATH’s Vaccine Access and Delivery Global Program. Other articles cover work to bring a rapid test for river blindness to market, use community-led videos to improve health, tackle diabetes and tuberculosis, and help public health managers with information systems.

Publication date: December 2013

Region: Global

Part of series: Directions in Global Health

Directions in Global Health (Volume 2, Issue 2)

The August 2005 issue of Directions in Global Health features five PATH projects: our work with in- and out-of-school youth as part of the African Youth Alliance, a new test for vitamin A deficiency, HIV prevention among vulnerable groups in Georgia, cost analysis of rapid syphilis tests, and home-based care of people living with AIDS in South Africa.

Author: PATH

Publication date: August 2005

Region: Global

Part of series: Directions in Global Health

Directions in Global Health (Volume 2, Issue 3)

The December 2005 issue of Directions in Global Health features five projects: PATH's Japanese encephalitis project, our collaboration with WHO on gender-based violence, a "lab-on-a-card" technology for detecting enteric disease, new HPV DNA tests for detecting cervical cancer, and an innovative behavior-change project that is helping prevent HIV in Eritrea.

Author: PATH

Publication date: December 2005

Region: Global

Part of series: Directions in Global Health

Directions in Global Health (Volume 5, Issue 2)

This special issue of Directions in Global Health describes PATH's work on HIV/AIDS. Featured projects focus on implementing interactive communication techniques that promote healthier behaviors, strengthening health systems to address the dual epidemics of HIV and tuberculosis, protecting youth against HIV, challenging gender norms to reduce the spread of HIV, and advancing innovative technologies for the prevention, diagnosis, and treatment of HIV/AIDS.

Publication date: August 2008

Region: Global

Part of series: Directions in Global Health

Directions in Global Health (Volume 6, Issue 2)

This issue of Directions in Global Health showcases PATH’s global presence. It highlights work related to influenza in Africa, HIV and AIDS in Eastern Europe,  Japanese encephalitis in Asia, gender-based violence in Latin America and the Caribbean, and diagnostic technologies in North America. The back cover features a map and summary information on PATH’s work around the world.

Publication date: August 2009

Region: Global

Part of series: Directions in Global Health

Directions in Global Health (Volume 7, Issue 2)

This issue of Directions in Global Health features a conversation with Chris Elias on the occasion of his ten-year anniversary as PATH’s president and CEO. It also highlights work to pave the way for a total market approach to family planning in Nicaragua and Vietnam, capitalize on the transformation potential of point-of-care tests, address gender’s impact on health, and design better health information systems for developing countries.

Publication date: December 2010

Region: Global

Part of series: Directions in Global Health

Directions in Global Health (Volume 9, Issue 2)

This issue of Directions in Global Health highlights PATH’s work to reduce the global burden of HIV/AIDS. It describes how PATH strengthens community-based responses; addresses gender norms to reduce HIV risk; integrates services for maximum effectiveness against HIV, tuberculosis, and other health challenges; advances needed technologies; and evaluates project impact. In addition, Dr. Julie Pulerwitz offers her perspective on turning the tide against AIDS.

Publication date: July 2012

Region: Global

Part of series: Directions in Global Health

Dry-Reagent Storage for Disposable Lab-on-Card Diagnosis of Enteric Pathogens

An exploration of one technique for drying reagents onto a microfluidics card. Reagents needed for immunocapture, lysis, and PCR for pathogen capture can be stored in trehalose or trehalose dextran. Presented at the 1st Distributed Diagnosis and Home Healthcare Conference, April 2, 2006; Arlington, VA.

Author: Ramachandran S, Weigl BH, Gerdes JC, et al

Publication date: April 2006

Region: Global

E6 Based Rapid Diagnostic Test for Cervical Pre-Cancer and Cancer

A pilot clinical study suggests that E6 is an appropriate biomarker for diagnosis of cervical pre-cancer and cancer in a novel oncoprotein-based rapid diagnostic assay for cervical pre-cancer and cancer. Presented at: International Papillomavirus Conference 2009, May 8, 2009; Malmo, Sweden.

Author: Schweizer J, Berard-Bergery M, Bisht A, et al

Publication date: May 2009

Region: Global

An E6 Oncoprotien Based Diagnostic Test for Cervical Pre-Cancer and Cancer

This poster describes the AV Avantage HPV E6 Test and the results from a small clinical pilot study. The AV Avantage HPV E6 Test uses high affinity mAb for the specific capture and detection of high-risk HPV-E6 oncoproteins in a lateral flow–based format. Presented at: 26th International Papillomavirus Conference, July 3, 2010; Montreal, Canada.

Author: Berard-Bergery M, Bisht A, Ho M, et al

Publication date: July 2010

Region: Global

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