Subject: Vaccines and immunization > Miscellaneous
- A Review of the United States Centers for Disease Control and Prevention Vaccine Management Business Improvement Project
In this document, project Optimize reviews the US Centers for Disease Control and Prevention’s (CDC’s) Vaccine Management Business Improvement Project, which represents an end-to-end reengineering of the US public-sector vaccine supply chain—from vaccine budgeting through storage and distribution. The CDC’s overarching goal was to ensure that vaccine was flowing to the right places at the right time.
Author: Wasserman N
Publication date: November 2010
- Vaccine Technologies at PATH
PATH and our partners have been advancing innovative vaccine technologies for more than 30 years. This report outlines our approach and capabilities. It also describes a number of individual vaccine technologies at various stages of development and market introduction to put this work in context.
Publication date: September 2010
- Vaccine Vial Monitor (VVM) Availability and Use in the African, Eastern Mediterranean, Southeast Asian, and Western Pacific Regions
Commissioned by project Optimize, a collaboration of PATH and the World Health Organization, a study of vaccine vial monitor (VVM) availability and use in developing countries in four regions was undertaken. The study had three aspects: the total proportion of vaccines with VVMs in the regions with detailed information by country, in-depth information on policies and practices, and knowledge and attitudes in a selected sample of countries.
Author: Milstein J
Publication date: August 2010
- Immunization Logistics and Supply Systems: From Vision to Action
In July 2010, project Optimize held workshops in Washington, DC, and Seattle, WA, to engage stakeholders from a wide variety of organizations. The workshops discussed developing-country immunization systems and sought participant perspectives on the desired future state of the systems. This document provides a summary of the workshops.
Publication date: July 2010
- Temperature Recording System in National Vaccine Stores of Khartoum, Sudan, and Tehran, Iran
Both Iran and Sudan utilize an alarm-based temperature recording system to monitor the performance of their national immunization cold stores. To better the utility and application of such systems in other countries, this project Optimize report documents the benefits, challenges, and advantages of both Iran’s and Sudan’s systems.
Author: Haghgou, M
Publication date: May 2010
- Improving the Affordability of Inactivated Poliovirus Vaccines (IPV) for Use in Low- and Middle-Income Countries: An Economic Analysis of Strategies to Reduce the Cost of Routine IPV Immunization
This report from the vaccine technologies team at PATH presents results from an economic model that calculates the costs involved in delivering IPV vaccine in Indian immunization clinics according to three strategies: (1) intradermal delivery of reduced volumes of vaccine per dose, (2) use of adjuvants to allow a reduced IPV antigen content per dose, and (3) reduction of the number of doses per IPV immunization schedule. The strategies include delivery by standard technique and with alternative delivery devices.
Author: Hickling J, Jones R, Nundi N, Zehrung D
Publication date: April 2010
- Optimize Phase I Summary Report: Evaluating the Vaccine Supply Chain in Preparation for Demonstrating Future Options in Vietnam
Project Optimize is collaborating with the Vietnamese National Institute of Hygiene and Epidemiology on a series of activities designed to assess the opportunities and needs for strengthening the immunization system in Vietnam. This document reports the results of assessments of the vaccine supply chain in Vietnam, completed in March 2010.
Publication date: March 2010
- Innovation in Action: Policies to Accelerate Development and Delivery of Global Health Tools
This report, the first annual policy report of the Global Health Technologies Coalition, makes recommendations for Congress and the Obama Administration to ensure that the United States maximizes its investment in global health and continues as a leader in global health research and development. The report makes recommendations in three areas: public financing, regulatory pathways, and incentives and innovative financing.
Publication date: 2010
Region: North America and Europe
Part of series: GHTC's annual policy reports
- Pull Mechanisms for Value-Added Technologies for Vaccines: An Evaluation of the Issues Influencing Vaccine Producer Willingness to Advance, Adopt, and Commercialize Value-Added Technologies for Vaccines for Low-Income and Lower-Middle-Income Country Markets
The Optimize project, a collaboration between PATH and the World Health Organization, commissioned this white paper to examine the issues influencing vaccine producer willingness to advance, adopt, and commercialize value-added technologies for vaccines for low-income and lower-middle-income country markets.
Author: Gilchrist S
Publication date: November 2009
- Optimize Strategy: 2009-2012
This document provides a brief overview of the Optimize project’s strategy for developing delivery systems that are as advanced and innovative as the vaccines they support. Project Optimize, a collaboration between the World Health Organization and PATH, has been given a unique mandate to think far into the future: to put technological and scientific advances to work, helping define the ideal characteristics and specifications for health products; and to create a vaccine supply chain that is flexible and robust enough to handle an increasingly large and costly portfolio of vaccines.
Publication date: October 2009
- Optimize: Immunization Systems and Technologies for Tomorrow
Project Optimize, a collaboration between the World Health Organization and PATH, has been given a unique mandate to think far into the future: to put technological and scientific advances to work, helping define the ideal characteristics and specifications for health products; and to create a vaccine supply chain that is flexible and robust enough to handle an increasingly large and costly portfolio of vaccines. This brochure provides an overview of Optimize's areas of focus and activities.
Publication date: August 2009
- Opportunities and Challenges of Developing Thermostable Vaccines
This article, published in Expert Reviews (Expert Rev. Vaccines 8(5), 547-557; May 2009), reviews approaches being used to develop thermostable vaccine formulations that are resistant to damage caused by freezing or excessive heat and could reduce dependence on the cold chain. The article discusses the challenges associated with the implementation of these novel formulations as well as the potential benefits of protecting vaccines from damage caused by breaks in the cold chain.
Author: Chen D, Kristensen D
Publication date: May 2009
- Use of Vaccines Outside of the Cold Chain: A Literature Review
This project Optimize study is a compilation of the literature available on the use of vaccines outside of the cold chain. Most of the studies analyzed in this review focus on hepatitis B, with one exception—a study examining meningococcal C vaccine.
Author: Villadiego S
Publication date: August 2008
- Landscape Analysis: Trends in Vaccine Availability and Novel Vaccine Delivery Technologies: 2008–2025
This project Optimize landscape analysis identifies trends in the availability of vaccines and novel vaccine delivery technologies that are and will be of relevance to low- and middle-income countries from present through 2025. The document is available as one large file or as three smaller sections for easier downloading.
Publication date: July 2008
- Landscape Analysis: Analysis of EVSM Indicators
The Effective Vaccine Stores Management (EVSM) assessment tool was created to help countries and agencies evaluate critical components of the country’s primary vaccine store. To date, 57 countries have completed the EVSM assessment. This project Optimize report evaluates 42 EVSM assessment spreadsheets.
Publication date: June 2008
- Landscape Analysis: Cool Chain Technologies
Technologies related to the temperature control of vaccines during the distribution process are essential to the cool chain. This project Optimize report provides a landscape analysis of these technologies and their appropriateness for use with vaccines in the developing world.
Publication date: June 2008
- Supportive Supervision to Sustain Health Worker Capacity in Nanggroe Aceh Darussalam and North Sumatera
This document summarizes PATH’s work in Indonesia to sustain best practices among health workers in project provinces through a supportive supervision program.
Publication date: April 2008
- Vietnam: Progress Beyond High Coverage - Increasing Immunization Program Quality, Safety, and Efficiency
Publication date: January 2007
- Improving Immunization Through Supportive Supervision
This fact sheet describes PATH's training of 70 immunization program supervisors in Vietnam's Ha Tinh Province to use supportive supervision methods, leading to immediate and significant improvements in performance.
Publication date: 2007
- Strengthening Vietnam's immunization program
PATH, in close partnership with Vietnam's National Expanded Program on Immunization (NEPI), has worked to increase the quality, safety, and efficiency of immunization services through the Iris Project. This fact sheet describes the project's process of testing province-wide systems improvements, identifying best practices, and encouraging other provinces to adopt the improvements. Work included updating and improving policies, training staff, and increasing community knowledge and demand for vaccination, particularly through technical updates, training of trainers, an introduction to supportive supervision, an out-of-the-cold-chain study, and an injection safety project with needle removers.
Publication date: 2007