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Subject: Health technologies

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Vaccine Resource Library Website

PATH’s Vaccine Resource Library (VRL) seeks to gather the world’s best immunization resources in a single, easy-to-use website. The VRL offers a wide variety of high-quality, scientifically accurate documents and links on specific diseases and topics in immunization. It is geared for health professionals in the developing and industrialized worlds, as well as for journalists, policymakers, community leaders, parents, and others interested in vaccine-related resources. The resources found on the VRL are collected from a variety of sources, including news media, scientific journals, and leaders in public health.

Publication date: 2014

Region: Global

Part of series: Websites

Vaccine Stabilization

Part of the Technology Updates series, this fact sheet describes PATH's work on vaccine stabilization, including the development of a method to protect vaccines containing an aluminum adjuvant from freeze damage, the identification of a technology to improve the heat stability of certain vaccines, and the improvement of vaccine stability through reformulation involving glass-forming sugars plus other excipients and processing via spray drying.

Publication date: May 2012

Region: Global

Part of series: Technology Updates

Vaccine Supply Chain Costing Methodology

Between 2009 and 2012, technical staff from project Optimize, a collaboration between PATH and the World Health Organization, worked to develop costing methodology and create an accompanying Microsoft Excel-based costing tool to help estimate the cost of the vaccine supply chain in Senegal and Vietnam. This report documents the methodology used to develop the costing tool.

Publication date: September 2013

Region: Global

Vaccine Technologies at PATH

PATH and our partners have been advancing innovative vaccine technologies for more than 30 years. This report outlines our approach and capabilities. It also describes a number of individual vaccine technologies at various stages of development and market introduction to put this work in context. 

Publication date: September 2010

Region: Global

Vaccine Vial Monitor (VVM) Availability and Use in the African, Eastern Mediterranean, Southeast Asian, and Western Pacific Regions

Commissioned by project Optimize, a collaboration of PATH and the World Health Organization, a study of vaccine vial monitor (VVM) availability and use in developing countries in four regions was undertaken. The study had three aspects: the total proportion of vaccines with VVMs in the regions with detailed information by country, in-depth information on policies and practices, and knowledge and attitudes in a selected sample of countries.

Author: Milstein J

Publication date: August 2010

Region: Global

Vaccine Vial Monitors

Part of the Technology Updates series, this fact sheet describes PATH's work on vaccine vial monitors.

Publication date: February 2014

Region: Global

Part of series: Technology Updates

Vaccine Vial Monitors: FAQs

Vaccine vial monitors (VVMs) are small stickers that adhere to vaccine vials and change color as the vaccine is exposed to heat, letting health workers know whether the vaccine can be safely used for immunization. This fact sheet answers the most frequently asked questions regarding VVMs.

Publication date: January 2011

Region: Global

Vaccines in Fast-Dissolving Tablets: Novel Product Format to Ensure Vaccine Effectiveness, Affordability, and Ease of Use

This fact sheet provides an overview of PATH's work in developing fast-dissolving tablet vaccine formulations manufactured using a standard lyophilization process. The tablets are packaged in unit-dose blisters, offering an inexpensive, scalable, and easy-to-use presentation for live attenuated vaccines containing single or multiple bacterial strains. Further, the stackable design may minimize product volume and thus the space required for storage and transport, resulting in significant savings for health systems and cold chains.

Publication date: March 2012

Region: Global

Vaccines in the Uniject™ Injection System

Part of the Technology Updates series, this fact sheet describes PATH's work on the Uniject™ injection system for use with vaccines.

Publication date: August 2013

Region: Global

Part of series: Technology Updates

Validation and Stability of Retinol-Binding Protein: Evidence From Tanzania

This document assesses the correspondence between retinol and retinol-binding protein (RBP), as well as the stability of RBP subjected to varying temperature conditions over time, the effect of light, and the feasibility of using dried blood spots. The assessment is part of a larger project examining the use of the RBP enzyme immunoassay (RBP-EIA) to test for vitamin A deficiency.

Publication date: 2006

Region: Africa

Validation of a Retinol-Binding Protein-Enzyme Immunoassay (RBP-EIA), Using Serum Specimens Collected From the Guinea-Bissau Health Project

This document shares data from Guinea-Bissau that provide validation of the retinol-binding protein enzyme immunoassay (RBP-EIA) test from serum samples, while also providing initial data on the feasibility of using dried blood samples as a specimen type for the assessment of vitamin A deficiency in the field.

Publication date: 2006

Region: Africa

Vietnam: Demonstrating Innovative Health Supply Chain Solutions

This document describes how project Optimize is collaborating with Vietnam’s National Institute of Hygiene and Epidemiology to demonstrate innovations in the supply chain that can help to meet the demands of an increasingly large and costly portfolio of vaccines.

Publication date: July 2012

Region: Asia

Vietnam’s Immunization Registries Go Online

In Vietnam, project Optimize worked with government and software partners to help introduce a digital immunization registry. This brief describes how the registry allowed the health system to better track children due for vaccination and shortened the time required for recording and reporting immunizations compared to the existing paper-based registry.

Publication date: January 2013

Region: Asia

Washington Global Health 2011 Strategic Mapping Portfolio

This report, commissioned by the Washington Global Health Alliance, identifies the global impact of 59 global health organizations in the state of Washington. Highlights from the report include the number of partnerships, number of projects, and number of employees in the global health sector. The report includes detailed graphics and project examples from many of the organizations.

Publication date: September 2011

Region: North America and Europe

Water Website

This website about the Safe Water Project within the Technology Solutions program provides an overview of the group and its featured projects. See other PATH program websites.

Publication date: 2014

Region: Global

Part of series: Program websites

"WaterGuard is the Smell of Safety": A Qualitative Exploration of Home Water Treatment Behaviors in an Antenatal Safe Water Program—Machinga, Malawi, 2011

Since 2006, PATH has investigated how commercial market forces can help extend access to safe water in developing countries and reduce waterborne disease. Promoting household water treatment and storage products targeted to low-income consumers is a key part of the strategy. This poster summarizes PATH's work in Malawi working with the US Centers for Disease Control and Prevention to assess the effects of an innovative program that promoted chlorine disinfectants for household water treatment to pregnant women seeking antenatal care. The poster was presented at the Water and Health: Where Science Meets Policy conference hosted by the University of North Carolina Water Institute in October 2012.

Author: Schlanger K, Woods S, Routh J, et al

Publication date: October 2012

Region: Africa

Woman's Condom

Part of the Technology Updates series, this fact sheet describes the Woman's Condom project at PATH.

Publication date: July 2013

Region: Global

Part of series: Technology Updates

Woman's Condom: Comfortable and Confident Protection for Women and Men

The Woman’s Condom is a new female condom designed to protect women and couples from unintended pregnancy and sexually transmitted infections and to be highly pleasurable. This document describes product features and the steps that PATH and our manufacturing partner, Shanghai Dahua Medical Apparatus Company, are taking to raise awareness and build demand. The Woman’s Condom is branded O’lavie™ in China.

Publication date: April 2013

Region: Global

Woman's Condom: Summary of Clinical Evaluation

The Woman's Condom is a new female condom that has been evaluated for acceptability, performance, and safety in clinical studies across five countries. This document summarizes key findings from completed clinical studies and provides updates on clinical studies in process.

Publication date: February 2013

Region: Global

Yellow Fever Vaccination: The Potential of Dose-Sparing to Increase Vaccine Supply and Availability

PATH commissioned this report in an effort to evaluate whether dose-sparing, possibly through the intradermal (ID) route, could improve the availability of yellow fever vaccine globally. The authors identify and discuss potential benefits, possible obstacles, and associated costs of dose-sparing as a vaccine delivery strategy. In addition, the report includes an assessment of which settings would be most appropriate and to what extent novel ID delivery devices, such as needle-free disposable-syringe jet injectors, would help to facilitate its successful implementation.

Author: Hickling J, Jones R

Publication date: April 2013

Region: Global

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