The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel offers an attractive target for developing a novel antisecretory to treat infectious diarrhea because it is the primary driver of secretion in cases of diarrhea caused by cholera. iOWH032 is a synthetic CFTR inhibitor that has been studied for this indication.
Author(s): de Hostos EL, Choy RKM, Nguyen T
Publication date: 2011
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