Subject: > Health technologies > Diagnostic technologies
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- Adaptation of Immunoassays for Multiplexed Diagnosis of a Diverse Panel of Pathogens Associated With Acute Febrile Illness
This poster summarizes PATH’s recent activities as part of a consortium lead by the University of Washington to develop the DxBox, a system comprising a portable instrument and low-cost disposable cards. The prototype is being developed to diagnose typhoid fever, dengue fever, rickettsial diseases, malaria, measles, and influenza. PATH’s contributions are immunoassay development, field studies, and user needs assessment. Presented at The American Society of Tropical Medicine and Hygiene (ASTMH), November 12, 2006; Atlanta, GA.
- Anemia Detection in Health Services: Guidelines for Program Managers
Anemia detection is often used as a screening test for iron deficiency. These guidelines are intended to help program managers establish anemia detection services or enhance existing services.
Publication date: 1996
Region: Global
- Anemia Detection Methods in Low-Resource Settings: A Manual for Health Workers
Publication date: 1997
Region: Global
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- CD4+ T-lymphocyte Test
Part of the Technology Updates series, this fact sheet describes PATH's work on a CD4+ T-lymphocyte test.
- Center for Point-of-Care Diagnostics for Global Health Website
The website for the Center for Point-of-Care Diagnostics for Global Health (GHDx Center) provides an overview of the GHDx Center’s activities and announces training and funding opportunities related to its goals. The GHDx Center works to improve the availability, accessibility, and affordability of essential point-of-care diagnostic tests for use in low-resource settings around the world.
- Chemically-Heated Non-Instrumented Nucleic-Acid Amplification Assay Platform
An overview of a diagnostic platform that PATH is developing based on nucleic-acid amplification that will require no instrumentation. It has the dual purpose of providing molecular diagnostics at the point of care as well as stabilizing nucleic-acid specimens for further analysis via a centralized surveillance system. Presented at the American Association for Clinical Chemistry 40th Annual Oak Ridge Conference, April 17, 2008; San Jose, CA.
- Correspondence Between RBP and Retinol From DBS Specimens Prepared From Capillary Blood: Evidence From Zimbabwe
This document provides evidence from a study in Zimbabwe that demonstrates the correspondence between serum retinol and retionol-binding protein in estimating the prevalence of and screening for vitamin A deficiency.
Publication date: 2006
Region: Africa
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- Detection and Characterization of Acute Febrile Illness in Western Kenya
This poster presents a study to collect and characterize specimens from febrile patients who were suspected to have malaria, pedigree specimens against a panel of nucleic acid and serological markers, and draw early insights into data that would be generated by a multiplex diagnostic platform. Presented at The American Society of Tropical Medicine and Hygiene, December 7, 2008; New Orleans, LA.
- Developing a Point-of-Care Multiplexed Diagnostic System for Low-Resource Settings in Developing Countries
A report on the selection and evaluation of target markers for a multiplex diagnostic platform under development. Based on the DxBox platform being developed as part of a public-private consortium lead by the University of Washington. Presented at the Molecular Medicine Tri-Conference, March 25, 2008; San Francisco, CA.
- Device for Automated Capture of E. coli O157:H7 From Feces: Feasibility for Point-of-Care Detection
This poster reports progress incorporating magnetic beads within a unique lab card that permits efficient capture and enrichment of E. coli O157:H7 from feces. Presented at the 106th General Meeting of the American Society for Microbiology, May 21, 2006; Orlando, FL.
- Directions in Global Health (Volume 2, Issue 2, August 2005)
The August 2005 issue of Directions in Global Health features five PATH projects: our work with in- and out-of-school youth as part of the African Youth Alliance, a new test for vitamin A deficiency, HIV prevention among vulnerable groups in Georgia, cost analysis of rapid syphilis tests, and home-based care of people living with AIDS in South Africa.
- Directions in Global Health (Volume 2, Issue 3, December 2005)
The December 2005 issue of Directions in Global Health features five projects: PATH's Japanese encephalitis project, our collaboration with WHO on gender-based violence, a "lab-on-a-card" technology for detecting enteric disease, new HPV DNA tests for detecting cervical cancer, and an innovative behavior-change project that is helping prevent HIV in Eritrea.
Part of series: Directions in Global Health
Author: PATH
Publication date: December 2005
Region: Global
- Directions in Global Health (Volume 5, Issue 2, August 2008)
This special issue of Directions in Global Health describes PATH's work on HIV/AIDS. Featured projects focus on implementing interactive communication techniques that promote healthier behaviors, strengthening health systems to address the dual epidemics of HIV and tuberculosis, protecting youth against HIV, challenging gender norms to reduce the spread of HIV, and advancing innovative technologies for the prevention, diagnosis, and treatment of HIV/AIDS.
- Directions in Global Health (Volume 6, Issue 2, August 2009)
This issue of Directions in Global Health showcases PATH’s global presence. It highlights work related to influenza in Africa, HIV and AIDS in Eastern Europe, Japanese encephalitis in Asia, gender-based violence in Latin America and the Caribbean, and diagnostic technologies in North America. The back cover features a map and summary information on PATH’s work around the world.
- Disposable Enterics Card
Part of the Technology Updates series, this fact sheet describes the disposable entrics card project at PATH.
- Dry-Reagent Storage for Disposable Lab-on-Card Diagnosis of Enteric Pathogens
An exploration of one technique for drying reagents onto a microfluidics card. Reagents needed for immunocapture, lysis, and PCR for pathogen capture can be stored in trehalose or trehalose dextran. Presented at the 1st Distributed Diagnosis and Home Healthcare Conference, April 2, 2006; Arlington, VA.
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- Efficacy of Standard Methods for Water Testing at a Range of Nonstandard Temperature
Fifteen strains of Escherichia coli from various geographical areas, animal, and soil sources were tested on standard and nonstandard detection assays at temperatures from 23°C to 45°C to test the viability of currently available E. coli tests in low-resource settings. Presented at the American Society for Microbiology Conference, June 1, 2008; Boston, MA.
- Examination of Venous and Capillary Blood Specimens for Assessment of Vitamin A Deficiency (Thailand Study)
This study provided the first evidence of the biological comparability between serum retinol levels estimated from venous blood and capillary blood. This critical observation provides empirical evidence that this important indicator of vitamin A status may be measured from capillary blood, which has important implications for nonclinical population-based research.
Author: Gorstein J; Dary O; Pongtorn; Shell-Duncan B; Quick T; Hix J; Kandavasee; Wasanwisut E
Publication date: 2005
Region: Asia
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- Falciparum Malaria IC Strip Test
Publication date: 2002
Region: Global
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- HealthTech Historical Profile: HIV Dipstick
Historical profile on the PATH development and advancement of the HIV dipstick.
Publication date: 2005
Region: North America and Europe
- HealthTech Historical Profile: Lateral-Flow, Point-of-Care Diagnostic Tests for Infectious Disease
Historical profile on the PATH development and advancement of point-of-care diagnostic tests.
Publication date: 2005
Region: North America and Europe
- Hepatitis B IC Strip Test
Publication date: 2002
Region: Global
- HIV Dipstick
Part of the Technology Updates series, this fact sheet describes the HIV dipstick project at PATH.
- HIV/AIDS Technologies: A Review of Progress to Date and Current Prospects
This paper was commissioned as an introductory landscape analysis for the aids2031 Science and Technology Working Group as part of a series of working papers under the aids2031 initiative. The paper builds on other recent landscape analysis work in the fields of HIV prevention technologies, therapeutics, and diagnostics and is intended to serve as a resource on the current status of research and development for biomedical and other technological interventions to prevent, treat, and diagnose HIV/AIDS.
Part of series: aids2031 working papers
Author: Alcorn K
Publication date: October 2008
Region: Global
- HPV DNA Testing: Technical and Programmatic Issues for Cervical Cancer Prevention in Low-resource Settings
- HPV Testing: Promise and Challenges
Publication date: 2003
Region: Global
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- Innovation in Biochemical Cervical Cancer Screening
This fact sheet gives an update regarding the two START project biochemical tests being developed to advance cervical cancer screening.
- Innovations in Cervical Cancer Screening
This fact sheet summarizes the work being done by PATH to develop two new tests to detect infection with cancer-causing human papillomavirus. Designed by the private sector—in partnership with PATH—for use in low-resource settings, these molecular and biochemical screening tools are an innovative answer to the challenge of preventing cervical cancer in the developing world.
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- Lab-on-a-Card Assay for Enteric Pathogens
We describe the functional elements of a diagnostic instrument and disposable enteric card system under development that rapidly identifies and differentiates Shigella, E. coli, Campylobacter, and Salmonella in stool samples. These elements, currently realized as microfluidic subcircuits on individual cards, are: (1) pathogen capture and lysing, (2) nucleic acid capture, (3) on-chip rapid PCR, and (4) lateral flow detection of amplicons. Presented at the Solid State Sensor, Actuator and Microsystems Workshop, June 4, 2006; Hilton Head Island, SC.
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- Point-of-care Diagnostics for Infectious Diseases: DxBox
Part of the Technology Updates series, this fact sheet describes PATH's work on the DxBox, a lab-on-a-card tool designed to help health care providers diagnose the cause of a patient's fever.
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- Rapid Diagnostics Website
Launched in 2002, this PATH website explores rapid diagnostic tests for infectiuos diseases, and provides information useful to international public health officials.
- Rapid Strip Test for Chlamydia
Part of the Technology Updates series, this fact sheet describes PATH's work to develop a rapid, easy-to-read, low-cost test for chlamydia.
- Rapid Strip Test for Gonorrhea
Part of the Technology Updates series, this fact sheet describes PATH's work to develop a rapid, easy-to-use, low-cost test for gonorrhea.
- Rapid Strip Test for Malaria
Part of the Technology Updates series, this fact sheet describes PATH's work to develop a rapid, easy-to-read, low-cost test for malaria.
- Rapid Tests for Cervical Cancer
Part of the Technology Updates series, this fact sheet describes PATH's work to develop rapid tests for cervical cancer.
- RBP-EIA: Collecting, Processing, and Handling Venous, Capillary, and Blood Spot Samples (Job Aid)
This document serves as a guide to phlebotomists and a training aid in the proper methods of obtaining blood samples for analysis by the retinol-binding protein enzyme immunoassay (RBP-EIA) used in testing for vitamin A deficiency.
Publication date: 2005
Region: Global
- RBP-EIA: A New Approach to Assessing Vitamin A Deficiency
This guide introduces the retinol binding protein enzyme immunoassay (RBP-EIA) to potential advocates and users, and provides information about its prospective role in public health.
- RBP-EIA: Validation and Establishment of a Rapid, Field-Based Tool for the Assessment of Vitamin A Deficiency: A Summary of Available Evidence
This document summarizes available evidence for the validation and establishment of a rapid, field-based tool for the assessment of vitamin A deficiency using the retinol-binding protein immunoassay (RBP-EIA) test.
Publication date: 2006
Region: Global
- Retinol Binding Protein Enzyme Immunoassay (RBP-EIA)
Part of the Technology Updates series, this fact sheet describes PATH's work to develop a rapid, low-cost test to detect vitamin A deficiency.
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- Simple and Affordable Testing for Multidrug-Resistant Tuberculosis
Part of the Technology Updates series, this fact sheet describes PATH's work on developing a simple, affordable test for multidrug resistant tuberculosis.
- Simple and Rapid Method for Detection of Enteric Pathogens in Stool Samples for Low-Resource Settings
Demonstration of the PATH enteric flow-through assay as a rapid and cost effective method for detecting pathogenic bacteria in stool samples in low-resource settings. Presented at the American Association for Clinical Chemistry Oak Ridge Annual Conference, April 17, 2006; San Jose, CA.
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- Validation and Stability of Retinol-Binding Protein: Evidence From Tanzania
This document assesses the correspondence between retinol and retinol-binding protein (RBP), as well as the stability of RBP subjected to varying temperature conditions over time, the effect of light, and the feasibility of using dried blood spots. The assessment is part of a larger project examining the use of the RBP enzyme immunoassay (RBP-EIA) to test for vitamin A deficiency.
Publication date: 2006
Region: Africa
- Validation of a Retinol-Binding Protein-Enzyme Immunocassay (RBP-EIA), Using Serum Specimens Collected From the Guinea-Bissau Health Project
This document shares data from Guinea-Bissau that provide validation of the retinol-binding protein enzyme immunoassay (RBP-EIA) test from serum samples, while also providing initial data on the feasibility of using dried blood samples as a specimen type for the assessment of vitamin A deficiency in the field.
Publication date: 2006
Region: Africa