Subject: > Vaccines and immunization > Diarrheal disease
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- Accelerating the Development of New Rotavirus Vaccines
This fact sheet highlights PATH's work to develop new vaccines against rotavirus, the leading cause of diarrheal disease.
- Advanced Immunization Management (AIM) e-Learning Website: Rotavirus
The AIM e-Learning tool is designed to provide comprehensive information to support immunization program managers at all stages of country-level decision-making. This module provides comprehensive information from basic rotavirus disease characteristics through immunization session planning for rotavirus vaccine introduction.
- An Integrated Approach to Confronting Diarrheal Disease
This briefing paper provides an overview of the tools and interventions involved with an integrated approach to diarrheal disease control, including vaccines, oral rehydration, breastfeeding, and zinc treatment. The document also advocates for renewed commitment at global, regional, and national levels.
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- Breastfeeding and Diarrhea
This fact sheet aims to raise awareness about breastfeeding to prevent and treat diarrhea. One in a set of introductory resources, it provides stakeholders and policymakers in the world’s poorest countries with crucial information on a proven intervention in the fight against diarrheal disease.
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- Common Virus and Senseless Killer: Briefing Paper on Rotavirus
This briefing paper underscores the burden of rotavirus and highlights the promise of vaccines to combat the virus as the global health community prepares for worldwide introduction.
Publication date: March 2009
Region: Global
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- Developing New Vaccines Against Diarrheal Disease
This fact sheet highlights PATH's work to develop safe, effective, and affordable vaccines against Shigella and enterotoxigenic Escherichia coli, two of the leading bacterial causes of diarrheal disease.
- Device for Automated Capture of E. coli O157:H7 From Feces: Feasibility for Point-of-Care Detection
This poster reports progress incorporating magnetic beads within a unique lab card that permits efficient capture and enrichment of E. coli O157:H7 from feces. Presented at the 106th General Meeting of the American Society for Microbiology, May 21, 2006; Orlando, FL.
- Diarrheal Disease: Solutions to Defeat a Global Killer
Diarrheal Disease: Solutions to Defeat a Global Killer presents scientific evidence to support strategies to scale up use of interventions, including safe water, improved sanitation and hygiene, breastfeeding and optimal complementary feeding, rotavirus vaccines, zinc treatment, and oral rehydration therapy/oral rehydration solution. In addition, the report features case studies of on-the-ground programs that bring these tools to communities that need them most. The document is available as one large file or as three smaller files for easier downloading.
Publication date: May 2009
Region: Global
- Directions in Global Health (Volume 2, Issue 1, April 2005)
The April 2005 issue of Directions in Global Health features five PATH projects: efforts to improve health among migrant communities in China, Thailand, and Cambodia; the Global Campaign for Microbicides, PATH's Woman's Condom, procurement of safe-injection supplies under the PEPFAR program, and the Rotavirus Vaccine Program.
- Directions in Global Health (Volume 4, Issue 1, May 2007)
This special issue of Directions in Global Health highlights PATH's vaccine partnership efforts: PATH Malaria Vaccine Initiative (MVI), pneumococcal vaccine development project, Meningitis Vaccine Project, cervical cancer vaccine project, and Rotavirus Vaccine Program. The issue also features a case study of the vaccine vial monitor.
- Directions in Global Health (Volume 5, Issue 3, December 2008)
This issue of Directions in Global Health describes PATH's work to control and prevent diarrheal disease, reach out to young scouts in Kenya and Uganda with HIV/AIDS information, assess the impact of malaria control efforts in Zambia, conduct DHS surveys, and shape HPV vaccine introduction in Peru.
Part of series: Directions in Global Health
Author: PATH
Publication date: December 2008
Region: Global
- Dry-Reagent Storage for Disposable Lab-on-Card Diagnosis of Enteric Pathogens
An exploration of one technique for drying reagents onto a microfluidics card. Reagents needed for immunocapture, lysis, and PCR for pathogen capture can be stored in trehalose or trehalose dextran. Presented at the 1st Distributed Diagnosis and Home Healthcare Conference, April 2, 2006; Arlington, VA.
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- Efficacy of Standard Methods for Water Testing at a Range of Nonstandard Temperature
Fifteen strains of Escherichia coli from various geographical areas, animal, and soil sources were tested on standard and nonstandard detection assays at temperatures from 23°C to 45°C to test the viability of currently available E. coli tests in low-resource settings. Presented at the American Society for Microbiology Conference, June 1, 2008; Boston, MA.
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- Introduction of Rotavirus Vaccine with Support from the GAVI Alliance: Information to Assist the National Decision-Making and Application Process
This guide summarizes considerations for rotavirus vaccine introduction in Eastern European countries eligible for support from the GAVI Alliance.
Publication date: December 2007
Region: Eastern Europe
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- Key Facts About Rotavirus Disease and Vaccines
Publication date: 2006
Region: Global
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- Lab-on-a-Card Assay for Enteric Pathogens
We describe the functional elements of a diagnostic instrument and disposable enteric card system under development that rapidly identifies and differentiates Shigella, E. coli, Campylobacter, and Salmonella in stool samples. These elements, currently realized as microfluidic subcircuits on individual cards, are: (1) pathogen capture and lysing, (2) nucleic acid capture, (3) on-chip rapid PCR, and (4) lateral flow detection of amplicons. Presented at the Solid State Sensor, Actuator and Microsystems Workshop, June 4, 2006; Hilton Head Island, SC.
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- Oral Rehydration Therapy/Oral Rehydration Solution
This fact sheet aims to raise awareness about oral rehydration therapy to rehydrate people—particularly infants and children—who have lost fluids because of diarrhea. One in a set of introductory resources, it provides stakeholders and policymakers in the world’s poorest countries with crucial information on a proven intervention in the fight against diarrheal disease.
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- The PATH Rotavirus Vaccine Program: Equal Protection Against a Childhood Threat
This fact sheet provides an update on the activities of the PATH Rotavirus Vaccine Program, which aims to dramatically reduce the typical 10- to 15-year timeline between introduction of new vaccines in wealthy countries and their availability in the developing world. Activities include measuring disease burden, determining vaccine efficacy and safety in developing countries, communicating the value of rotavirus vaccines, and generating information on the health economics of rotavirus vaccination.
- Protecting Young Children From Diarrheal Disease
This fact sheet provides an overview of PATH's multifaceted approach to protecting children from diarrheal disease.
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- Resources for Diarrheal Disease Control
This resource-rich site provides tools that advocates and practitioners alike can use in spreading the word about the deadly toll of diarrheal disease and the solutions to stop it, including new technologies such as zinc treatment and rotavirus vaccines, as well as traditional interventions such as oral rehydration therapy, clean water, and breastfeeding.
- Rotavirus Questions and Answers
Publication date: 2006
Region: Global
- Rotavirus Update and RotaFlash
Rotavirus Update is distributed every other month to our colleagues in the global health community. It provides the latest news on the development of vaccines against rotavirus, a diarrheal disease that afflicts children worldwide and can lead to severe, sometimes fatal, dehydration. This newsletter reports on progress made by PATH and partners toward bringing a rotavirus vaccine to children in the world’s poorest countries. RotaFlash serves as a supplement between issues of the Rotavirus Update newsletter, providing breaking news on rotavirus disease and vaccines. When you subscribe to Rotavirus Update, you will also receive occasional emails to keep you up to date on the field's latest developments.
- Rotavirus Vaccine Program (RVP) Brochure
This brochure describes the global burden of disease from rotavirus and the Rotavirus Vaccine Program's work in accelerating the availability of a rotavirus vaccine.
Publication date: 2004
Region: Global
- Rotavirus Vaccine Program Website
Launched in 2004, this website provides news and resources from PATH’s Rotavirus Vaccine Program, whose mission is to reduce child morbidity and mortality from diarrheal disease by accelerating the availability of rotavirus vaccines appropriate for use in developing countries.
- Rotavirus Vaccines
This fact sheet aims to raise awareness about two new vaccines against rotavirus, a major cause of diarrheal disease. One in a set of introductory resources, it provides stakeholders and policymakers in the world’s poorest countries with crucial information on new tools to fight diarrheal disease.
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- Simple and Rapid Method for Detection of Enteric Pathogens in Stool Samples for Low-Resource Settings
Demonstration of the PATH enteric flow-through assay as a rapid and cost effective method for detecting pathogenic bacteria in stool samples in low-resource settings. Presented at the American Association for Clinical Chemistry Oak Ridge Annual Conference, April 17, 2006; San Jose, CA.
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- Vaccine Resource Library
PATH’s Vaccine Resource Library (VRL) seeks to gather the world’s best immunization resources in a single, easy-to-use website. The VRL offers a wide variety of high-quality, scientifically accurate documents and links on specific diseases and topics in immunization. It is geared for health professionals in the developing and industrialized worlds, as well as for journalists, policymakers, community leaders, parents, and others interested in vaccine-related resources. The resources found on the VRL are collected from a variety of sources, including news media, scientific journals, and leaders in public health.
- Vaccines for the Future
This e-newsletter provides a periodic update on PATH’s efforts to develop new, appropriate, and affordable vaccines against two leading causes of death in developing-world populations: pneumonia and diarrhea. It includes updates on our progress, partnerships, and specific projects related to vaccines against pneumococcal disease, rotavirus, Shigella, enterotoxigenic E. coli (ETEC), and influenza.
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- Zinc Treatment for Diarrhea
This fact sheet aims to raise awareness about zinc, a new treatment for diarrhea. One in a set of introductory resources, it provides stakeholders and policymakers in the world’s poorest countries with crucial information on a new tool to fight diarrheal disease.
